Long-Term Stimulation and Recording with a Penetrating Microelectrode Array in Cat Sciatic Nerve

Almut Branner, Richard B. Stein, Eduardo Fernandez, Yoichiro Aoyagi, Richard A. Normann

Research output: Contribution to journalArticle

187 Citations (Scopus)

Abstract

We studied the consequences of long-term implantation of a penetrating microelectrode array in peripheral nerve over the time course of 4-6 mo. Electrode arrays without lead wires were implanted to test the ability of different containment systems to protect the array and nerve during contractions of surrounding muscles. Treadmill walking was monitored and the animals showed no functional deficits as a result of implantation. In a different set of experiments, electrodes with lead wires were implanted for up to 7 mo and the animals were tested at 2-4 week intervals at which time stimulation thresholds and recorded sensory activity were monitored for every electrode. It was shown that surgical technique highly affected the long-term stimulation results. Results between measurement sessions were compared, and in the best case, the stimulation properties stabilized in 80% of the electrodes over the course of the experiment (162 days). The recorded sensory signals, however, were not stable over time. A histological analysis performed on all implanted tissues indicated that the morphology and fiber density of the nerve around the electrodes were normal.

Original languageEnglish
Pages (from-to)146-157
Number of pages12
JournalIEEE Transactions on Biomedical Engineering
Volume51
Issue number1
DOIs
Publication statusPublished - 01-01-2004

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Microelectrodes
Electrodes
Animals
Lead
Wire
Exercise equipment
Muscle
Experiments
Tissue
Fibers

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

Cite this

Branner, Almut ; Stein, Richard B. ; Fernandez, Eduardo ; Aoyagi, Yoichiro ; Normann, Richard A. / Long-Term Stimulation and Recording with a Penetrating Microelectrode Array in Cat Sciatic Nerve. In: IEEE Transactions on Biomedical Engineering. 2004 ; Vol. 51, No. 1. pp. 146-157.
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Long-Term Stimulation and Recording with a Penetrating Microelectrode Array in Cat Sciatic Nerve. / Branner, Almut; Stein, Richard B.; Fernandez, Eduardo; Aoyagi, Yoichiro; Normann, Richard A.

In: IEEE Transactions on Biomedical Engineering, Vol. 51, No. 1, 01.01.2004, p. 146-157.

Research output: Contribution to journalArticle

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