TY - JOUR
T1 - Long-term survival of young women receiving fertility-sparing surgery for ovarian cancer in comparison with those undergoing radical surgery
AU - Kajiyama, H.
AU - Shibata, K.
AU - Mizuno, M.
AU - Umezu, T.
AU - Suzuki, S.
AU - Nawa, A.
AU - Kawai, M.
AU - Nagasaka, T.
AU - Kikkawa, F.
PY - 2011/10/25
Y1 - 2011/10/25
N2 - Objectives:To compare the clinical outcome of patients with stage I epithelial ovarian cancer (EOC) who received with fertility-sparing surgery (FSS) with those who underwent radical surgery (RS). Methods: After a central pathological review and search of the medical records from multiple institutions, a total of 572 patients were retrospectively evaluated. All patients were divided into three groups: group A FSS (n=74); age, ≤40; groups B and C RS; age, 40>(B), n=52; 40<(C), n=446. Results: Five-year overall survival (OS) and disease-free survival (DFS) rates of patients in the groups were as follows: group A, 90.8% (OS)/87.9% (DFS); group B, 88.3% (OS)/84.4% (DFS); group C, 90.6% (OS)/85.3% (DFS), respectively (OS, P=0.802; DFS, P=0.765). Additionally, there was no significant difference in OS and DFS among the three groups stratified to stage IA or IC (OS (IA), P=0.387; DFS (IA), P=0.314; OS (IC), P=0.993; DFS (IC), P=0.990, respectively). Furthermore, patients with a grade 1-2 or 3 tumours in the FSS group did not have a poorer prognosis than those in the RS group.Conclusions:Stage I EOC patients treated with FSS showed an acceptable prognosis compared with those who underwent RS.
AB - Objectives:To compare the clinical outcome of patients with stage I epithelial ovarian cancer (EOC) who received with fertility-sparing surgery (FSS) with those who underwent radical surgery (RS). Methods: After a central pathological review and search of the medical records from multiple institutions, a total of 572 patients were retrospectively evaluated. All patients were divided into three groups: group A FSS (n=74); age, ≤40; groups B and C RS; age, 40>(B), n=52; 40<(C), n=446. Results: Five-year overall survival (OS) and disease-free survival (DFS) rates of patients in the groups were as follows: group A, 90.8% (OS)/87.9% (DFS); group B, 88.3% (OS)/84.4% (DFS); group C, 90.6% (OS)/85.3% (DFS), respectively (OS, P=0.802; DFS, P=0.765). Additionally, there was no significant difference in OS and DFS among the three groups stratified to stage IA or IC (OS (IA), P=0.387; DFS (IA), P=0.314; OS (IC), P=0.993; DFS (IC), P=0.990, respectively). Furthermore, patients with a grade 1-2 or 3 tumours in the FSS group did not have a poorer prognosis than those in the RS group.Conclusions:Stage I EOC patients treated with FSS showed an acceptable prognosis compared with those who underwent RS.
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U2 - 10.1038/bjc.2011.394
DO - 10.1038/bjc.2011.394
M3 - Article
C2 - 21970882
AN - SCOPUS:80055018754
SN - 0007-0920
VL - 105
SP - 1288
EP - 1294
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 9
ER -
