TY - JOUR
T1 - Longitudinal changes of macular curvature in patients with retinitis pigmentosa
AU - Meinert, Monika
AU - Ueno, Shinji
AU - Komori, Shiori
AU - Koyanagi, Yoshito
AU - Sayo, Akira
AU - Andreasson, Sten
AU - Kominami, Taro
AU - Ito, Yasuki
AU - Terasaki, Hiroko
N1 - Funding Information:
Supported in part by KAKENHI Grants from the Japan Society for the Promotion of Science (19K09928 to S.U; 16K11265 to Y.I.).
Funding Information:
The authors thank Duco Hamasaki, PhD (Bascom Palmer Eye Institute), for the discussions and editing the final version of the manuscript. This research was conducted on behalf of the Joint PhD program between Nagoya University and Lund University. Supported in part by KAKENHI Grants from the Japan Society for the Promotion of Science (19K09928 to S.U; 16K11265 to Y.I.).
Publisher Copyright:
© 2020 The Authors.
PY - 2020
Y1 - 2020
N2 - Purpose: To investigate the longitudinal changes of the macular curvature in eyes with retinitis pigmentosa (RP) and to determine the factors associated with the changes. Methods: We reviewed the medical charts of 107 RP patients, for whom the axial length of their right eyes ranged from 21.5 to 26.0 mm and who had had been followed by spectral-domain optical coherence tomography (OCT). The OCT images at the initial and the most recent examinations were compared. The mean curvature of Bruch’s membrane within 6 mm of the central macula obtained from the OCT images was evalu-ated as the mean macular curvature index (MMCI). Changes in the MMCI and their relationships with other clinical factors, including the ellipsoid zone (EZ) width, were assessed. Results: The MMCI decreased significantly in the vertical OCT images, from –15.47 × 10−5 μm−1 to –16.36 × 10−5 μm−1 (P = 0.008) during the mean observation period of 3.4 ± 1.4 years (mean ± SD). This indicated that the macular shape became more concave. The change to a steeper shape was more prominent in eyes with less photoreceptor degeneration and for which the EZ width was preserved at >2000 μm. In three eyes, the MMCI increased markedly by >5 × 10−5 μm−1, and this was accompanied by absorption of the macular edema. Conclusions: The macular curvature in RP eyes becomes more concave in eyes with preserved EZ width. Translational Relevance: Longitudinal changes of the macular curvature in RP should be considered in future therapies, such as the implantation of the retinal prosthesis.
AB - Purpose: To investigate the longitudinal changes of the macular curvature in eyes with retinitis pigmentosa (RP) and to determine the factors associated with the changes. Methods: We reviewed the medical charts of 107 RP patients, for whom the axial length of their right eyes ranged from 21.5 to 26.0 mm and who had had been followed by spectral-domain optical coherence tomography (OCT). The OCT images at the initial and the most recent examinations were compared. The mean curvature of Bruch’s membrane within 6 mm of the central macula obtained from the OCT images was evalu-ated as the mean macular curvature index (MMCI). Changes in the MMCI and their relationships with other clinical factors, including the ellipsoid zone (EZ) width, were assessed. Results: The MMCI decreased significantly in the vertical OCT images, from –15.47 × 10−5 μm−1 to –16.36 × 10−5 μm−1 (P = 0.008) during the mean observation period of 3.4 ± 1.4 years (mean ± SD). This indicated that the macular shape became more concave. The change to a steeper shape was more prominent in eyes with less photoreceptor degeneration and for which the EZ width was preserved at >2000 μm. In three eyes, the MMCI increased markedly by >5 × 10−5 μm−1, and this was accompanied by absorption of the macular edema. Conclusions: The macular curvature in RP eyes becomes more concave in eyes with preserved EZ width. Translational Relevance: Longitudinal changes of the macular curvature in RP should be considered in future therapies, such as the implantation of the retinal prosthesis.
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U2 - 10.1167/tvst.9.10.11
DO - 10.1167/tvst.9.10.11
M3 - Article
AN - SCOPUS:85090634975
SN - 2164-2591
VL - 9
SP - 1
EP - 8
JO - Translational Vision Science and Technology
JF - Translational Vision Science and Technology
IS - 10
M1 - 11
ER -