TY - JOUR
T1 - Longitudinal patterns of Alzheimer's disease subtypes
T2 - A follow-up magnetic resonance imaging and single-photon emission computed tomography study
AU - Hanyu, Haruo
AU - Koyama, Yumi
AU - Horita, Haruka
AU - Watanabe, Sadayoshi
AU - Sato, Tomohiko
AU - Kanetaka, Hidekazu
AU - Shimizu, Soichiro
AU - Hirao, Kentaro
N1 - Publisher Copyright:
© 2023 Japan Geriatrics Society.
PY - 2023/12
Y1 - 2023/12
N2 - Aim: Alzheimer's disease (AD) is a biologically heterogenous disease. In a previous study, we classified 245 patients with probable AD into the typical AD (TAD), limbic-predominant (LP), hippocampal-sparing (HS) and minimal-change (MC) subtypes based on their medial temporal lobe atrophy on magnetic resonance imaging and posterior hypoperfusion on single-photon emission computed tomography, and described differences in clinical features among the patients with different AD subtypes. This study aimed to clarify the longitudinal patterns of changes in patients with the various AD subtypes by follow-up brain imaging analyses. Methods: Follow-up magnetic resonance imaging or single-photon emission computed tomography data obtained 12–48 months after the first brain imaging were investigated in 79 patients with probable AD, comprising 25 of the TAD subtype, 19 of the LP subtype, 17 of the HS subtype and 18 of the MC subtype. Results: All patients of the TAD subtype remained as the same subtype at follow up. Approximately 37% of patients of the LP subtype and 29% of patients of the HS subtype progressed to the TAD subtype, and 17%, 33% and 6% of the MC subtype progressed to the TAD, LP and HS subtypes, respectively. The group of patients showing subtype progression was associated only with a longer follow-up duration. Conclusions: There might be different progression patterns and progression rates of changes among the atypical AD subtypes. Further longitudinal brain imaging studies might provide information regarding the pathophysiological association between the various AD subtypes, and might be helpful for determining appropriate therapies and management methods. Geriatr Gerontol Int 2023; 23: 919–924.
AB - Aim: Alzheimer's disease (AD) is a biologically heterogenous disease. In a previous study, we classified 245 patients with probable AD into the typical AD (TAD), limbic-predominant (LP), hippocampal-sparing (HS) and minimal-change (MC) subtypes based on their medial temporal lobe atrophy on magnetic resonance imaging and posterior hypoperfusion on single-photon emission computed tomography, and described differences in clinical features among the patients with different AD subtypes. This study aimed to clarify the longitudinal patterns of changes in patients with the various AD subtypes by follow-up brain imaging analyses. Methods: Follow-up magnetic resonance imaging or single-photon emission computed tomography data obtained 12–48 months after the first brain imaging were investigated in 79 patients with probable AD, comprising 25 of the TAD subtype, 19 of the LP subtype, 17 of the HS subtype and 18 of the MC subtype. Results: All patients of the TAD subtype remained as the same subtype at follow up. Approximately 37% of patients of the LP subtype and 29% of patients of the HS subtype progressed to the TAD subtype, and 17%, 33% and 6% of the MC subtype progressed to the TAD, LP and HS subtypes, respectively. The group of patients showing subtype progression was associated only with a longer follow-up duration. Conclusions: There might be different progression patterns and progression rates of changes among the atypical AD subtypes. Further longitudinal brain imaging studies might provide information regarding the pathophysiological association between the various AD subtypes, and might be helpful for determining appropriate therapies and management methods. Geriatr Gerontol Int 2023; 23: 919–924.
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U2 - 10.1111/ggi.14712
DO - 10.1111/ggi.14712
M3 - Article
C2 - 37905589
AN - SCOPUS:85175495014
SN - 1444-1586
VL - 23
SP - 919
EP - 924
JO - Geriatrics and Gerontology International
JF - Geriatrics and Gerontology International
IS - 12
ER -