Abstract
The NF2 tumor suppressor gene product, designated merlin, belongs to the family of molecules that links membranous protein with the cytoskeleton. We have previously shown that merlin was co-immunoprecipitated with a cellular protein, p85, in cultured cell. To analyze the alteration of merlin and associated proteins in surgical specimens, we developed a new method for biotin-labeling of whole cellular proteins. Screening of tumor tissues using our method showed that none of malignant gliomas and half of the NF2-related tumors had altered p85 and merlin. Our detection method seems useful for the screening of merlin alterations in NF2-related tumors.
| Original language | English |
|---|---|
| Pages (from-to) | 1073-1078 |
| Number of pages | 6 |
| Journal | International journal of oncology |
| Volume | 12 |
| Issue number | 5 |
| Publication status | Published - 05-1998 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
