Low Birth Weight Is Associated With Reduced Adiponectin Concentration in Adult

Koji Tamakoshi, Hiroshi Yatsuya, Keiko Wada, Kunihiro Matsushita, Rei Otsuka, Kaichiro Sugiura, Takaaki Kondo, Hideaki Toyoshima

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose: Low birth weight has been associated with metabolic and vascular diseases, but the precise mechanism is debated. Adiponectin is one of the key molecules in metabolic disease, and a decrease in level precedes the onset of type 2 diabetes and development of atherosclerosis. Our aim is to examine whether low birth weight is associated with adiponectin concentration in adult. Methods: We conducted a population-based cross-sectional study of 2277 subjects (1661 men and 616 women) aged 35 to 66 years who had their self-reported birth weights and adiponectin concentrations measured as adults. Results: After adjusting for potential confounders, including age, sex, current body mass index (BMI), smoking status, alcohol consumption, and exercise, geometric mean adiponectin levels were 6.63, 6.45, 6.86, 7.05, 6.75, and 7.22 μg/mL for subjects with birth weights less than 2500, 2500 to less than 2800, 2800 to less than 3000, 3000 to less than 3200, 3200 to less than 3500, and greater than 3500 g, respectively. A positive association was found between birth weight and adiponectin concentration (trend p = 0.002). Stratified by current BMI of 25 kg/m2, a positive association was not observed for subjects with a BMI less than 25 kg/m2, but was pronounced in those with a BMI of 25 kg/m2 or greater. Conclusion: This study indicates that low birth weight contributes to decreased adiponectin concentrations in adult life independently of current BMI, especially for obese subjects.

Original languageEnglish
Pages (from-to)669-674
Number of pages6
JournalAnnals of Epidemiology
Volume16
Issue number9
DOIs
Publication statusPublished - 01-09-2006

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Adiponectin
Low Birth Weight Infant
Body Mass Index
Birth Weight
Metabolic Diseases
Vascular Diseases
Alcohol Drinking
Type 2 Diabetes Mellitus
Atherosclerosis
Cross-Sectional Studies
Smoking
Exercise
Population

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Tamakoshi, K., Yatsuya, H., Wada, K., Matsushita, K., Otsuka, R., Sugiura, K., ... Toyoshima, H. (2006). Low Birth Weight Is Associated With Reduced Adiponectin Concentration in Adult. Annals of Epidemiology, 16(9), 669-674. https://doi.org/10.1016/j.annepidem.2006.01.005
Tamakoshi, Koji ; Yatsuya, Hiroshi ; Wada, Keiko ; Matsushita, Kunihiro ; Otsuka, Rei ; Sugiura, Kaichiro ; Kondo, Takaaki ; Toyoshima, Hideaki. / Low Birth Weight Is Associated With Reduced Adiponectin Concentration in Adult. In: Annals of Epidemiology. 2006 ; Vol. 16, No. 9. pp. 669-674.
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Tamakoshi, K, Yatsuya, H, Wada, K, Matsushita, K, Otsuka, R, Sugiura, K, Kondo, T & Toyoshima, H 2006, 'Low Birth Weight Is Associated With Reduced Adiponectin Concentration in Adult', Annals of Epidemiology, vol. 16, no. 9, pp. 669-674. https://doi.org/10.1016/j.annepidem.2006.01.005

Low Birth Weight Is Associated With Reduced Adiponectin Concentration in Adult. / Tamakoshi, Koji; Yatsuya, Hiroshi; Wada, Keiko; Matsushita, Kunihiro; Otsuka, Rei; Sugiura, Kaichiro; Kondo, Takaaki; Toyoshima, Hideaki.

In: Annals of Epidemiology, Vol. 16, No. 9, 01.09.2006, p. 669-674.

Research output: Contribution to journalArticle

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AU - Tamakoshi, Koji

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AU - Sugiura, Kaichiro

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AU - Toyoshima, Hideaki

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N2 - Purpose: Low birth weight has been associated with metabolic and vascular diseases, but the precise mechanism is debated. Adiponectin is one of the key molecules in metabolic disease, and a decrease in level precedes the onset of type 2 diabetes and development of atherosclerosis. Our aim is to examine whether low birth weight is associated with adiponectin concentration in adult. Methods: We conducted a population-based cross-sectional study of 2277 subjects (1661 men and 616 women) aged 35 to 66 years who had their self-reported birth weights and adiponectin concentrations measured as adults. Results: After adjusting for potential confounders, including age, sex, current body mass index (BMI), smoking status, alcohol consumption, and exercise, geometric mean adiponectin levels were 6.63, 6.45, 6.86, 7.05, 6.75, and 7.22 μg/mL for subjects with birth weights less than 2500, 2500 to less than 2800, 2800 to less than 3000, 3000 to less than 3200, 3200 to less than 3500, and greater than 3500 g, respectively. A positive association was found between birth weight and adiponectin concentration (trend p = 0.002). Stratified by current BMI of 25 kg/m2, a positive association was not observed for subjects with a BMI less than 25 kg/m2, but was pronounced in those with a BMI of 25 kg/m2 or greater. Conclusion: This study indicates that low birth weight contributes to decreased adiponectin concentrations in adult life independently of current BMI, especially for obese subjects.

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