Low circulating CD34+ cell count is associated with poor prognosis in chronic hemodialysis patients

Shoichi Maruyama, Akihiko Taguchi, Shigejiro Iwashima, Takenori Ozaki, Kaoru Yasuda, Akie Kikuchi-Taura, Toshihiro Soma, Hideki Ishii, Toyoaki Murohara, Hiroshi Takahashi, Hirotake Kasuga, Yoshitaka Kumada, Takanobu Toriyama, Yasuhiko Ito, Hirohisa Kawahara, Yukio Yuzawa, Seiichi Matsuo

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Circulating CD34-positive (CD34+) cells, a population that includes endothelial progenitor cells, are believed to contribute to vascular homeostasis. Here we determine the prognostic value of CD34+ cell measurements in 216 chronic hemodialysis patients. A total of 43 cardiovascular events and 13 deaths occurred over an average 23 months follow-up in this cohort. A cutoff number for circulating CD34+ cells was determined by receiver operating characteristic curve analysis to maximize the power of the CD34+ cell count in predicting future cardiovascular events. Based on this, 93 patients were categorized as having low and 123 patients as having high numbers of CD34+ cells, determined by flow cytometry at the time of enrollment. Both cumulative cardiovascular event-free survival and all-cause survival were significantly less in the group of patients with low numbers of CD34+ cells. By multivariate analyses, a low level of circulating CD34+ cells was an independent and significant predictor for both cardiovascular events and all-cause mortality. Our study shows that a reduced number of circulating CD34+ cells is significantly associated with vascular risks and all-cause mortality in patients on chronic hemodialysis. These cells may be a useful biomarker.

Original languageEnglish
Pages (from-to)1603-1609
Number of pages7
JournalKidney International
Volume74
Issue number12
DOIs
Publication statusPublished - 01-12-2008
Externally publishedYes

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Renal Dialysis
Cell Count
Blood Vessels
Mortality
ROC Curve
Disease-Free Survival
Flow Cytometry
Homeostasis
Multivariate Analysis
Biomarkers
Survival
Population

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Maruyama, S., Taguchi, A., Iwashima, S., Ozaki, T., Yasuda, K., Kikuchi-Taura, A., ... Matsuo, S. (2008). Low circulating CD34+ cell count is associated with poor prognosis in chronic hemodialysis patients. Kidney International, 74(12), 1603-1609. https://doi.org/10.1038/ki.2008.495
Maruyama, Shoichi ; Taguchi, Akihiko ; Iwashima, Shigejiro ; Ozaki, Takenori ; Yasuda, Kaoru ; Kikuchi-Taura, Akie ; Soma, Toshihiro ; Ishii, Hideki ; Murohara, Toyoaki ; Takahashi, Hiroshi ; Kasuga, Hirotake ; Kumada, Yoshitaka ; Toriyama, Takanobu ; Ito, Yasuhiko ; Kawahara, Hirohisa ; Yuzawa, Yukio ; Matsuo, Seiichi. / Low circulating CD34+ cell count is associated with poor prognosis in chronic hemodialysis patients. In: Kidney International. 2008 ; Vol. 74, No. 12. pp. 1603-1609.
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Maruyama, S, Taguchi, A, Iwashima, S, Ozaki, T, Yasuda, K, Kikuchi-Taura, A, Soma, T, Ishii, H, Murohara, T, Takahashi, H, Kasuga, H, Kumada, Y, Toriyama, T, Ito, Y, Kawahara, H, Yuzawa, Y & Matsuo, S 2008, 'Low circulating CD34+ cell count is associated with poor prognosis in chronic hemodialysis patients', Kidney International, vol. 74, no. 12, pp. 1603-1609. https://doi.org/10.1038/ki.2008.495

Low circulating CD34+ cell count is associated with poor prognosis in chronic hemodialysis patients. / Maruyama, Shoichi; Taguchi, Akihiko; Iwashima, Shigejiro; Ozaki, Takenori; Yasuda, Kaoru; Kikuchi-Taura, Akie; Soma, Toshihiro; Ishii, Hideki; Murohara, Toyoaki; Takahashi, Hiroshi; Kasuga, Hirotake; Kumada, Yoshitaka; Toriyama, Takanobu; Ito, Yasuhiko; Kawahara, Hirohisa; Yuzawa, Yukio; Matsuo, Seiichi.

In: Kidney International, Vol. 74, No. 12, 01.12.2008, p. 1603-1609.

Research output: Contribution to journalArticle

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T1 - Low circulating CD34+ cell count is associated with poor prognosis in chronic hemodialysis patients

AU - Maruyama, Shoichi

AU - Taguchi, Akihiko

AU - Iwashima, Shigejiro

AU - Ozaki, Takenori

AU - Yasuda, Kaoru

AU - Kikuchi-Taura, Akie

AU - Soma, Toshihiro

AU - Ishii, Hideki

AU - Murohara, Toyoaki

AU - Takahashi, Hiroshi

AU - Kasuga, Hirotake

AU - Kumada, Yoshitaka

AU - Toriyama, Takanobu

AU - Ito, Yasuhiko

AU - Kawahara, Hirohisa

AU - Yuzawa, Yukio

AU - Matsuo, Seiichi

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N2 - Circulating CD34-positive (CD34+) cells, a population that includes endothelial progenitor cells, are believed to contribute to vascular homeostasis. Here we determine the prognostic value of CD34+ cell measurements in 216 chronic hemodialysis patients. A total of 43 cardiovascular events and 13 deaths occurred over an average 23 months follow-up in this cohort. A cutoff number for circulating CD34+ cells was determined by receiver operating characteristic curve analysis to maximize the power of the CD34+ cell count in predicting future cardiovascular events. Based on this, 93 patients were categorized as having low and 123 patients as having high numbers of CD34+ cells, determined by flow cytometry at the time of enrollment. Both cumulative cardiovascular event-free survival and all-cause survival were significantly less in the group of patients with low numbers of CD34+ cells. By multivariate analyses, a low level of circulating CD34+ cells was an independent and significant predictor for both cardiovascular events and all-cause mortality. Our study shows that a reduced number of circulating CD34+ cells is significantly associated with vascular risks and all-cause mortality in patients on chronic hemodialysis. These cells may be a useful biomarker.

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Maruyama S, Taguchi A, Iwashima S, Ozaki T, Yasuda K, Kikuchi-Taura A et al. Low circulating CD34+ cell count is associated with poor prognosis in chronic hemodialysis patients. Kidney International. 2008 Dec 1;74(12):1603-1609. https://doi.org/10.1038/ki.2008.495