TY - JOUR
T1 - Low dose of 1,3-di(2-tolyl)guanidine (DTG) attenuates MK-801-induced spatial working memory impairment in mice
AU - Maurice, Tangui
AU - Hiramatsu, Masayuki
AU - Itoh, Jiro
AU - Kameyama, Tsutomu
AU - Hasegawa, Takaaki
AU - Nabeshima, Toshitaka
PY - 1994/4/1
Y1 - 1994/4/1
N2 - MK-801 (30-100 μg/kg, SC) impaired spontaneous alternation behavior of mice, a behavior related to the spatial working memory. 1,3-Di-(2-tolyl)guanidine (DTG),(+)-pentazocine and (+)-SKF 10,047 (100 μg/kg, SC), putative σ agonists, administered 10 min before MK-801, partially but significantly reversed the impairment, without affecting the concomitant hyperlocomotion. The antagonizing effects by DTG were prevented by BMY-14802 (5 mg/kg, IP), a purported σ antagonist. These findings suggest that, at low doses, σ ligands may modulate the N-methyl-d-aspartate dependent memory processes.
AB - MK-801 (30-100 μg/kg, SC) impaired spontaneous alternation behavior of mice, a behavior related to the spatial working memory. 1,3-Di-(2-tolyl)guanidine (DTG),(+)-pentazocine and (+)-SKF 10,047 (100 μg/kg, SC), putative σ agonists, administered 10 min before MK-801, partially but significantly reversed the impairment, without affecting the concomitant hyperlocomotion. The antagonizing effects by DTG were prevented by BMY-14802 (5 mg/kg, IP), a purported σ antagonist. These findings suggest that, at low doses, σ ligands may modulate the N-methyl-d-aspartate dependent memory processes.
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U2 - 10.1007/BF02249345
DO - 10.1007/BF02249345
M3 - Article
C2 - 7855212
AN - SCOPUS:0028356429
VL - 114
SP - 520
EP - 522
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 3
ER -