Low dose of 1,3-di(2-tolyl)guanidine (DTG) attenuates MK-801-induced spatial working memory impairment in mice

Tangui Maurice, Masayuki Hiramatsu, Jiro Itoh, Tsutomu Kameyama, Takaaki Hasegawa, Toshitaka Nabeshima

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

MK-801 (30-100 μg/kg, SC) impaired spontaneous alternation behavior of mice, a behavior related to the spatial working memory. 1,3-Di-(2-tolyl)guanidine (DTG),(+)-pentazocine and (+)-SKF 10,047 (100 μg/kg, SC), putative σ agonists, administered 10 min before MK-801, partially but significantly reversed the impairment, without affecting the concomitant hyperlocomotion. The antagonizing effects by DTG were prevented by BMY-14802 (5 mg/kg, IP), a purported σ antagonist. These findings suggest that, at low doses, σ ligands may modulate the N-methyl-d-aspartate dependent memory processes.

Original languageEnglish
Pages (from-to)520-522
Number of pages3
JournalPsychopharmacology
Volume114
Issue number3
DOIs
Publication statusPublished - 01-04-1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology

Fingerprint Dive into the research topics of 'Low dose of 1,3-di(2-tolyl)guanidine (DTG) attenuates MK-801-induced spatial working memory impairment in mice'. Together they form a unique fingerprint.

  • Cite this

    Maurice, T., Hiramatsu, M., Itoh, J., Kameyama, T., Hasegawa, T., & Nabeshima, T. (1994). Low dose of 1,3-di(2-tolyl)guanidine (DTG) attenuates MK-801-induced spatial working memory impairment in mice. Psychopharmacology, 114(3), 520-522. https://doi.org/10.1007/BF02249345