Low dose of 1,3-di(2-tolyl)guanidine (DTG) attenuates MK-801-induced spatial working memory impairment in mice

Tangui Maurice, Masayuki Hiramatsu, Jiro Itoh, Tsutomu Kameyama, Takaaki Hasegawa, Toshitaka Nabeshima

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

MK-801 (30-100 μg/kg, SC) impaired spontaneous alternation behavior of mice, a behavior related to the spatial working memory. 1,3-Di-(2-tolyl)guanidine (DTG),(+)-pentazocine and (+)-SKF 10,047 (100 μg/kg, SC), putative σ agonists, administered 10 min before MK-801, partially but significantly reversed the impairment, without affecting the concomitant hyperlocomotion. The antagonizing effects by DTG were prevented by BMY-14802 (5 mg/kg, IP), a purported σ antagonist. These findings suggest that, at low doses, σ ligands may modulate the N-methyl-d-aspartate dependent memory processes.

Original languageEnglish
Pages (from-to)520-522
Number of pages3
JournalPsychopharmacology
Volume114
Issue number3
DOIs
Publication statusPublished - 01-04-1994
Externally publishedYes

Fingerprint

Dizocilpine Maleate
Short-Term Memory
Pentazocine
Aspartic Acid
Ligands
1,3-ditolylguanidine
Spatial Memory
alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Maurice, Tangui ; Hiramatsu, Masayuki ; Itoh, Jiro ; Kameyama, Tsutomu ; Hasegawa, Takaaki ; Nabeshima, Toshitaka. / Low dose of 1,3-di(2-tolyl)guanidine (DTG) attenuates MK-801-induced spatial working memory impairment in mice. In: Psychopharmacology. 1994 ; Vol. 114, No. 3. pp. 520-522.
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Low dose of 1,3-di(2-tolyl)guanidine (DTG) attenuates MK-801-induced spatial working memory impairment in mice. / Maurice, Tangui; Hiramatsu, Masayuki; Itoh, Jiro; Kameyama, Tsutomu; Hasegawa, Takaaki; Nabeshima, Toshitaka.

In: Psychopharmacology, Vol. 114, No. 3, 01.04.1994, p. 520-522.

Research output: Contribution to journalArticle

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