Abstract
MK-801 (30-100 μg/kg, SC) impaired spontaneous alternation behavior of mice, a behavior related to the spatial working memory. 1,3-Di-(2-tolyl)guanidine (DTG),(+)-pentazocine and (+)-SKF 10,047 (100 μg/kg, SC), putative σ agonists, administered 10 min before MK-801, partially but significantly reversed the impairment, without affecting the concomitant hyperlocomotion. The antagonizing effects by DTG were prevented by BMY-14802 (5 mg/kg, IP), a purported σ antagonist. These findings suggest that, at low doses, σ ligands may modulate the N-methyl-d-aspartate dependent memory processes.
| Original language | English |
|---|---|
| Pages (from-to) | 520-522 |
| Number of pages | 3 |
| Journal | Psychopharmacology |
| Volume | 114 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 01-04-1994 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Pharmacology
Fingerprint Dive into the research topics of 'Low dose of 1,3-di(2-tolyl)guanidine (DTG) attenuates MK-801-induced spatial working memory impairment in mice'. Together they form a unique fingerprint.
Cite this
Maurice, T., Hiramatsu, M., Itoh, J., Kameyama, T., Hasegawa, T., & Nabeshima, T. (1994). Low dose of 1,3-di(2-tolyl)guanidine (DTG) attenuates MK-801-induced spatial working memory impairment in mice. Psychopharmacology, 114(3), 520-522. https://doi.org/10.1007/BF02249345