Low dose of 1,3-di(2-tolyl)guanidine (DTG) attenuates MK-801-induced spatial working memory impairment in mice

Tangui Maurice; Masayuki Hiramatsu; Jiro Itoh; Tsutomu Kameyama; Takaaki Hasegawa; Toshitaka Nabeshima

doi:10.1007/BF02249345

Low dose of 1,3-di(2-tolyl)guanidine (DTG) attenuates MK-801-induced spatial working memory impairment in mice

Tangui Maurice, Masayuki Hiramatsu, Jiro Itoh, Tsutomu Kameyama, Takaaki Hasegawa, Toshitaka Nabeshima

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

MK-801 (30-100 μg/kg, SC) impaired spontaneous alternation behavior of mice, a behavior related to the spatial working memory. 1,3-Di-(2-tolyl)guanidine (DTG),(+)-pentazocine and (+)-SKF 10,047 (100 μg/kg, SC), putative σ agonists, administered 10 min before MK-801, partially but significantly reversed the impairment, without affecting the concomitant hyperlocomotion. The antagonizing effects by DTG were prevented by BMY-14802 (5 mg/kg, IP), a purported σ antagonist. These findings suggest that, at low doses, σ ligands may modulate the N-methyl-d-aspartate dependent memory processes.

Original language	English
Pages (from-to)	520-522
Number of pages	3
Journal	Psychopharmacology
Volume	114
Issue number	3
DOIs	https://doi.org/10.1007/BF02249345
Publication status	Published - 01-04-1994
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology

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10.1007/BF02249345

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title = "Low dose of 1,3-di(2-tolyl)guanidine (DTG) attenuates MK-801-induced spatial working memory impairment in mice",

abstract = "MK-801 (30-100 μg/kg, SC) impaired spontaneous alternation behavior of mice, a behavior related to the spatial working memory. 1,3-Di-(2-tolyl)guanidine (DTG),(+)-pentazocine and (+)-SKF 10,047 (100 μg/kg, SC), putative σ agonists, administered 10 min before MK-801, partially but significantly reversed the impairment, without affecting the concomitant hyperlocomotion. The antagonizing effects by DTG were prevented by BMY-14802 (5 mg/kg, IP), a purported σ antagonist. These findings suggest that, at low doses, σ ligands may modulate the N-methyl-d-aspartate dependent memory processes.",

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AU - Maurice, Tangui

AU - Hiramatsu, Masayuki

AU - Itoh, Jiro

AU - Kameyama, Tsutomu

AU - Hasegawa, Takaaki

AU - Nabeshima, Toshitaka

PY - 1994/4/1

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AB - MK-801 (30-100 μg/kg, SC) impaired spontaneous alternation behavior of mice, a behavior related to the spatial working memory. 1,3-Di-(2-tolyl)guanidine (DTG),(+)-pentazocine and (+)-SKF 10,047 (100 μg/kg, SC), putative σ agonists, administered 10 min before MK-801, partially but significantly reversed the impairment, without affecting the concomitant hyperlocomotion. The antagonizing effects by DTG were prevented by BMY-14802 (5 mg/kg, IP), a purported σ antagonist. These findings suggest that, at low doses, σ ligands may modulate the N-methyl-d-aspartate dependent memory processes.

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