Abstract
MK-801 (30-100 μg/kg, SC) impaired spontaneous alternation behavior of mice, a behavior related to the spatial working memory. 1,3-Di-(2-tolyl)guanidine (DTG),(+)-pentazocine and (+)-SKF 10,047 (100 μg/kg, SC), putative σ agonists, administered 10 min before MK-801, partially but significantly reversed the impairment, without affecting the concomitant hyperlocomotion. The antagonizing effects by DTG were prevented by BMY-14802 (5 mg/kg, IP), a purported σ antagonist. These findings suggest that, at low doses, σ ligands may modulate the N-methyl-d-aspartate dependent memory processes.
| Original language | English |
|---|---|
| Pages (from-to) | 520-522 |
| Number of pages | 3 |
| Journal | Psychopharmacology |
| Volume | 114 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 01-04-1994 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Pharmacology
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Low dose of 1,3-di(2-tolyl)guanidine (DTG) attenuates MK-801-induced spatial working memory impairment in mice. / Maurice, Tangui; Hiramatsu, Masayuki; Itoh, Jiro; Kameyama, Tsutomu; Hasegawa, Takaaki; Nabeshima, Toshitaka.
In: Psychopharmacology, Vol. 114, No. 3, 01.04.1994, p. 520-522.Research output: Contribution to journal › Article
TY - JOUR
T1 - Low dose of 1,3-di(2-tolyl)guanidine (DTG) attenuates MK-801-induced spatial working memory impairment in mice
AU - Maurice, Tangui
AU - Hiramatsu, Masayuki
AU - Itoh, Jiro
AU - Kameyama, Tsutomu
AU - Hasegawa, Takaaki
AU - Nabeshima, Toshitaka
PY - 1994/4/1
Y1 - 1994/4/1
N2 - MK-801 (30-100 μg/kg, SC) impaired spontaneous alternation behavior of mice, a behavior related to the spatial working memory. 1,3-Di-(2-tolyl)guanidine (DTG),(+)-pentazocine and (+)-SKF 10,047 (100 μg/kg, SC), putative σ agonists, administered 10 min before MK-801, partially but significantly reversed the impairment, without affecting the concomitant hyperlocomotion. The antagonizing effects by DTG were prevented by BMY-14802 (5 mg/kg, IP), a purported σ antagonist. These findings suggest that, at low doses, σ ligands may modulate the N-methyl-d-aspartate dependent memory processes.
AB - MK-801 (30-100 μg/kg, SC) impaired spontaneous alternation behavior of mice, a behavior related to the spatial working memory. 1,3-Di-(2-tolyl)guanidine (DTG),(+)-pentazocine and (+)-SKF 10,047 (100 μg/kg, SC), putative σ agonists, administered 10 min before MK-801, partially but significantly reversed the impairment, without affecting the concomitant hyperlocomotion. The antagonizing effects by DTG were prevented by BMY-14802 (5 mg/kg, IP), a purported σ antagonist. These findings suggest that, at low doses, σ ligands may modulate the N-methyl-d-aspartate dependent memory processes.
UR - http://www.scopus.com/inward/record.url?scp=0028356429&partnerID=8YFLogxK
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U2 - 10.1007/BF02249345
DO - 10.1007/BF02249345
M3 - Article
VL - 114
SP - 520
EP - 522
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 3
ER -