TY - JOUR
T1 - Low Frequency of Rearrangements of the ret and trk Proto‐oncogenes in Japanese Thyroid Papillary Carcinomas
AU - Wajjwalku, Worawidh
AU - Nakamura, Shigeo
AU - Hasegawa, Yasuhisa
AU - Miyazaki, Koichi
AU - Satoh, Yasuyuki
AU - Funahashi, Hiroomi
AU - Matsuyama, Mutsushi
AU - Takahashi, Masahide
PY - 1992/7
Y1 - 1992/7
N2 - We investigated the frequency of rearrangements of the ret and trk proto‐oncogenes in Japanese thyroid tumors. DNAs from 38 thyroid papillary carcinomas and 14 follicular adenomas were analyzed by Southern blotting. Rearrangements of the ret and trk proto‐oncogenes were detected in one and two papillary carcinomas, respectively, but not in follicular adenomas. Analysis by a reverse transcriptase‐polymerase chain reaction method showed that the ret rearrangement‐positive tumor contained the PTC/refTPCchimeric transcript, which was reported to be found specifically in thyroid tumors and adenomatous goiter. We also found that rearranged mRNA of the trk proto‐oncogene was expressed at high levels in one of two trk rearrangement‐positive tumors. Our results indicated that the frequency of rearrangements of these proto‐oncogenes in Japanese papillary carcinomas was much lower than that in Italian patients.
AB - We investigated the frequency of rearrangements of the ret and trk proto‐oncogenes in Japanese thyroid tumors. DNAs from 38 thyroid papillary carcinomas and 14 follicular adenomas were analyzed by Southern blotting. Rearrangements of the ret and trk proto‐oncogenes were detected in one and two papillary carcinomas, respectively, but not in follicular adenomas. Analysis by a reverse transcriptase‐polymerase chain reaction method showed that the ret rearrangement‐positive tumor contained the PTC/refTPCchimeric transcript, which was reported to be found specifically in thyroid tumors and adenomatous goiter. We also found that rearranged mRNA of the trk proto‐oncogene was expressed at high levels in one of two trk rearrangement‐positive tumors. Our results indicated that the frequency of rearrangements of these proto‐oncogenes in Japanese papillary carcinomas was much lower than that in Italian patients.
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U2 - 10.1111/j.1349-7006.1992.tb01963.x
DO - 10.1111/j.1349-7006.1992.tb01963.x
M3 - Article
C2 - 1381340
AN - SCOPUS:0026686316
SN - 0910-5050
VL - 83
SP - 671
EP - 675
JO - Japanese Journal of Cancer Research
JF - Japanese Journal of Cancer Research
IS - 7
ER -