Low-grade intraductal carcinoma of the salivary gland with prominent oncocytic change: a newly described variant

Masato Nakaguro, Makoto Urano, Hiroaki Suzuki, Kazuyuki Yamada, Asumi Sakaguchi, Kanako Ogura, Toshiharu Matsumoto, Noritsugu Ono, Tsuguharu Asato, Yoshiki Mikami, Hiroshi Imai, Toshitaka Nagao

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Abstract

Aims: Low-grade intraductal carcinoma (LG-IDC) is a clinically indolent malignant tumour of the salivary glands. Because of its rarity, the histological variants of LG-IDC have not been well characterised. Herein, we describe five LG-IDC cases with prominent oncocytic change in the major salivary glands. Methods and results: We examined five cases, three males and two females (mean age = 63 years), of LG-IDC with oncocytic change. The sites affected by LG-IDC were the parotid and submandibular glands. The lesions were macroscopically unilocular or multilocular cysts with a solid tumour arising from the cyst wall. Smaller tumour cell nests were also observed. As with classic LG-IDC, the cyst wall was surrounded by myoepithelial cells with no invasive component. The tumour cells had abundant oncocytic cytoplasm and proliferated in a low-papillary, tubular or cribriform pattern. Immunohistochemically, the tumour cells were diffusely positive for pan-cytokeratin, S100, mammaglobin and antimitochondria antibody, and were negative for androgen receptor and gross cystic disease fluid protein-15. Unlike classic LG-IDC, some of these cases demonstrated focal invagination of myoepithelial cells in the intraductal tumour. Conclusion: Oncocytic LG-IDC should be recognised as a histologically unique variant of LG-IDC. Awareness of this entity is important to avoid erroneous diagnosis and inappropriate treatment for histological mimics.

Original languageEnglish
Pages (from-to)314-320
Number of pages7
JournalHistopathology
Volume73
Issue number2
DOIs
Publication statusPublished - 08-2018

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

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    Nakaguro, M., Urano, M., Suzuki, H., Yamada, K., Sakaguchi, A., Ogura, K., Matsumoto, T., Ono, N., Asato, T., Mikami, Y., Imai, H., & Nagao, T. (2018). Low-grade intraductal carcinoma of the salivary gland with prominent oncocytic change: a newly described variant. Histopathology, 73(2), 314-320. https://doi.org/10.1111/his.13517