Low intake of vegetables and fruits and risk of colorectal cancer: The japan collaborative cohort study

The JACC Study Group

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: The evidence for an association between low intake of vegetables and fruits and increased colorectal cancer risk is inconclusive. Evaluating the colorectal cancer risk associated with continued low intake is important. Methods: We used data of 45 516 and 14 549 subjects aged 40-79 years obtained in the baseline and interim surveys, respectively, from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study). The intake frequency of vegetables and fruits as assessed by a self-administered questionnaire was classified into tertiles of low, middle, and high groups, and the low group was subdivided into 2 equal groups (lower low and higher low groups). Colorectal cancer incidence determined from follow-up was used. Cox's proportional hazard model was employed to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for covariates. Results: During 598 605 person-years of subject follow-up after baseline, we identified 806 colorectal cancer cases. HRs for the lower low versus the middle and high intake frequencies of vegetables and fruits at baseline were 0.95 (95% CI 0.77-1.16) and 1.08 (95% CI 0.90-1.29), respectively. During 125 980 person-years of subject follow-up after the interim survey, 197 colorectal cancer cases were identified. HRs for the low versus middle and high intake frequencies of vegetables and fruits in both baseline and interim surveys were 0.91 (95% CI 0.61-1.37) and 0.87 (95% CI 0.59-1.27), respectively. Conclusions: Our results suggest that low intake and continued low intake of vegetables and fruits are not strongly associated with colorectal cancer risk.

Original languageEnglish
Pages (from-to)353-360
Number of pages8
JournalJournal of epidemiology
Volume24
Issue number5
DOIs
Publication statusPublished - 01-01-2014

Fingerprint

Vegetables
Colorectal Neoplasms
Fruit
Japan
Cohort Studies
Confidence Intervals
Proportional Hazards Models
Surveys and Questionnaires
Incidence
Neoplasms

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

@article{0d82b87cda9c4dc08cb7592a29a915e6,
title = "Low intake of vegetables and fruits and risk of colorectal cancer: The japan collaborative cohort study",
abstract = "Background: The evidence for an association between low intake of vegetables and fruits and increased colorectal cancer risk is inconclusive. Evaluating the colorectal cancer risk associated with continued low intake is important. Methods: We used data of 45 516 and 14 549 subjects aged 40-79 years obtained in the baseline and interim surveys, respectively, from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study). The intake frequency of vegetables and fruits as assessed by a self-administered questionnaire was classified into tertiles of low, middle, and high groups, and the low group was subdivided into 2 equal groups (lower low and higher low groups). Colorectal cancer incidence determined from follow-up was used. Cox's proportional hazard model was employed to estimate the hazard ratios (HRs) and 95{\%} confidence intervals (CIs), adjusting for covariates. Results: During 598 605 person-years of subject follow-up after baseline, we identified 806 colorectal cancer cases. HRs for the lower low versus the middle and high intake frequencies of vegetables and fruits at baseline were 0.95 (95{\%} CI 0.77-1.16) and 1.08 (95{\%} CI 0.90-1.29), respectively. During 125 980 person-years of subject follow-up after the interim survey, 197 colorectal cancer cases were identified. HRs for the low versus middle and high intake frequencies of vegetables and fruits in both baseline and interim surveys were 0.91 (95{\%} CI 0.61-1.37) and 0.87 (95{\%} CI 0.59-1.27), respectively. Conclusions: Our results suggest that low intake and continued low intake of vegetables and fruits are not strongly associated with colorectal cancer risk.",
author = "{The JACC Study Group} and Norihiro Aoyama and Miyuki Kawado and Hiroya Yamada and Shuji Hashimoto and Koji Suzuki and Kenji Wakai and Sadao Suzuki and Yoshiyuki Watanabe and Akiko Tamakoshi and Mitsuru Mori and Fumio Sakauchi and Yutaka Motohashi and Ichiro Tsuji and Yosikazu Nakamura and Hiroyasu Iso and Haruo Mikami and Michiko Kurosawa and Yoshiharu Hoshiyama and Naohito Tanabe and Koji Tamakoshi and Shinkan Tokudome and Shogo Kikuchi and Yasuhiko Wada and Takashi Kawamura and Kotaro Ozasa and Tsuneharu Miki and Chigusa Date and Kiyomi Sakata and Yoichi Kurozawa and Takesumi Yoshimura and Yoshihisa Fujino and Akira Shibata and Naoyuki Okamoto and Hideo Shio",
year = "2014",
month = "1",
day = "1",
doi = "10.2188/jea.JE20130195",
language = "English",
volume = "24",
pages = "353--360",
journal = "Journal of Epidemiology",
issn = "0917-5040",
publisher = "Japan Epidemiology Association",
number = "5",

}

Low intake of vegetables and fruits and risk of colorectal cancer : The japan collaborative cohort study. / The JACC Study Group.

In: Journal of epidemiology, Vol. 24, No. 5, 01.01.2014, p. 353-360.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Low intake of vegetables and fruits and risk of colorectal cancer

T2 - The japan collaborative cohort study

AU - The JACC Study Group

AU - Aoyama, Norihiro

AU - Kawado, Miyuki

AU - Yamada, Hiroya

AU - Hashimoto, Shuji

AU - Suzuki, Koji

AU - Wakai, Kenji

AU - Suzuki, Sadao

AU - Watanabe, Yoshiyuki

AU - Tamakoshi, Akiko

AU - Mori, Mitsuru

AU - Sakauchi, Fumio

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Haruo

AU - Kurosawa, Michiko

AU - Hoshiyama, Yoshiharu

AU - Tanabe, Naohito

AU - Tamakoshi, Koji

AU - Tokudome, Shinkan

AU - Kikuchi, Shogo

AU - Wada, Yasuhiko

AU - Kawamura, Takashi

AU - Ozasa, Kotaro

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Kurozawa, Yoichi

AU - Yoshimura, Takesumi

AU - Fujino, Yoshihisa

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: The evidence for an association between low intake of vegetables and fruits and increased colorectal cancer risk is inconclusive. Evaluating the colorectal cancer risk associated with continued low intake is important. Methods: We used data of 45 516 and 14 549 subjects aged 40-79 years obtained in the baseline and interim surveys, respectively, from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study). The intake frequency of vegetables and fruits as assessed by a self-administered questionnaire was classified into tertiles of low, middle, and high groups, and the low group was subdivided into 2 equal groups (lower low and higher low groups). Colorectal cancer incidence determined from follow-up was used. Cox's proportional hazard model was employed to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for covariates. Results: During 598 605 person-years of subject follow-up after baseline, we identified 806 colorectal cancer cases. HRs for the lower low versus the middle and high intake frequencies of vegetables and fruits at baseline were 0.95 (95% CI 0.77-1.16) and 1.08 (95% CI 0.90-1.29), respectively. During 125 980 person-years of subject follow-up after the interim survey, 197 colorectal cancer cases were identified. HRs for the low versus middle and high intake frequencies of vegetables and fruits in both baseline and interim surveys were 0.91 (95% CI 0.61-1.37) and 0.87 (95% CI 0.59-1.27), respectively. Conclusions: Our results suggest that low intake and continued low intake of vegetables and fruits are not strongly associated with colorectal cancer risk.

AB - Background: The evidence for an association between low intake of vegetables and fruits and increased colorectal cancer risk is inconclusive. Evaluating the colorectal cancer risk associated with continued low intake is important. Methods: We used data of 45 516 and 14 549 subjects aged 40-79 years obtained in the baseline and interim surveys, respectively, from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study). The intake frequency of vegetables and fruits as assessed by a self-administered questionnaire was classified into tertiles of low, middle, and high groups, and the low group was subdivided into 2 equal groups (lower low and higher low groups). Colorectal cancer incidence determined from follow-up was used. Cox's proportional hazard model was employed to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for covariates. Results: During 598 605 person-years of subject follow-up after baseline, we identified 806 colorectal cancer cases. HRs for the lower low versus the middle and high intake frequencies of vegetables and fruits at baseline were 0.95 (95% CI 0.77-1.16) and 1.08 (95% CI 0.90-1.29), respectively. During 125 980 person-years of subject follow-up after the interim survey, 197 colorectal cancer cases were identified. HRs for the low versus middle and high intake frequencies of vegetables and fruits in both baseline and interim surveys were 0.91 (95% CI 0.61-1.37) and 0.87 (95% CI 0.59-1.27), respectively. Conclusions: Our results suggest that low intake and continued low intake of vegetables and fruits are not strongly associated with colorectal cancer risk.

UR - http://www.scopus.com/inward/record.url?scp=84921667693&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921667693&partnerID=8YFLogxK

U2 - 10.2188/jea.JE20130195

DO - 10.2188/jea.JE20130195

M3 - Article

C2 - 24857954

AN - SCOPUS:84921667693

VL - 24

SP - 353

EP - 360

JO - Journal of Epidemiology

JF - Journal of Epidemiology

SN - 0917-5040

IS - 5

ER -