Low-level release of Shiga-like toxin (Verocytotoxin) and endotoxin from enterohemorrhagic Escherichia coli treated with imipenem

Kazuko Takahashi, Kayou Narita, Yutaka Kato, Tsuyoshi Sugiyama, Naoki Koide, Tomoaki Yoshida, Takashi Yokochi

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Shiga-like toxin (SLT) and endotoxin may participate in the pathogenesis of enterohemorrhagic Escherichia coli (EHEC) infection. Levels of release of SLT and endotoxin from EHEC treated in vitro with antibiotics were estimated. There were differential levels of release of SLT and endotoxin from EHEC treated with different antibiotics. Treatment of EHEC strains, namely, E. coli O157, O111, and O26, with imipenem induced much lower levels of release of SLT and endotoxin than treatment with ceftazidime.

Original languageEnglish
Pages (from-to)2295-2296
Number of pages2
JournalAntimicrobial agents and chemotherapy
Volume41
Issue number10
DOIs
Publication statusPublished - 10-1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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