Abstract
Background. The myositis-specific autoantibodies that characterize certain forms of inflammatory myopathy are useful in diagnosing dermatomyositis (DM) / polymyositis and predicting its prognosis. Autoantibodies to small ubiquitin-like modifier activating enzyme (SAE) have been identified as a DM-marker antibody in European Caucasians. Objective and methods. This study investigates the frequency and clinical characteristics of anti-SAE autoantibodies in Japanese patients with DM. Sera from 110 Japanese patients, including 13 with juvenile DM, were screened for anti-SAE antibodies by enzyme-linked immunosorbent assays. Positive sera were further examined by immunoblotting of the immunoprecipitates. Results. Only two patients (1.8%) were confirmed to have anti-SAE antibodies, and neither of these two patients had amyopathic or juvenile DM. One patient with anti-SAE had DM complicated with pulmonary arterial hypertension, and the other had cancer-associated DM. Both had hallmark cutaneous manifestations of DM. Conclusion. This is the first report of anti-SAE antibodies from an Asian single center cohort. Although Japanese patients with anti-SAE antibodies have a clinical phenotype similar to that of Caucasian patients, their frequency was lower in the Japanese patients than in the previously reported Caucasian patients.
| Original language | English |
|---|---|
| Pages (from-to) | 279-284 |
| Number of pages | 6 |
| Journal | Autoimmunity |
| Volume | 46 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 01-06-2013 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
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Low prevalence of anti-small ubiquitin-like modifier activating enzyme antibodies in dermatomyositis patients. / Muro, Yoshinao; Sugiura, Kazumitsu; Akiyama, Masashi.
In: Autoimmunity, Vol. 46, No. 4, 01.06.2013, p. 279-284.Research output: Contribution to journal › Article
TY - JOUR
T1 - Low prevalence of anti-small ubiquitin-like modifier activating enzyme antibodies in dermatomyositis patients
AU - Muro, Yoshinao
AU - Sugiura, Kazumitsu
AU - Akiyama, Masashi
PY - 2013/6/1
Y1 - 2013/6/1
N2 - Background. The myositis-specific autoantibodies that characterize certain forms of inflammatory myopathy are useful in diagnosing dermatomyositis (DM) / polymyositis and predicting its prognosis. Autoantibodies to small ubiquitin-like modifier activating enzyme (SAE) have been identified as a DM-marker antibody in European Caucasians. Objective and methods. This study investigates the frequency and clinical characteristics of anti-SAE autoantibodies in Japanese patients with DM. Sera from 110 Japanese patients, including 13 with juvenile DM, were screened for anti-SAE antibodies by enzyme-linked immunosorbent assays. Positive sera were further examined by immunoblotting of the immunoprecipitates. Results. Only two patients (1.8%) were confirmed to have anti-SAE antibodies, and neither of these two patients had amyopathic or juvenile DM. One patient with anti-SAE had DM complicated with pulmonary arterial hypertension, and the other had cancer-associated DM. Both had hallmark cutaneous manifestations of DM. Conclusion. This is the first report of anti-SAE antibodies from an Asian single center cohort. Although Japanese patients with anti-SAE antibodies have a clinical phenotype similar to that of Caucasian patients, their frequency was lower in the Japanese patients than in the previously reported Caucasian patients.
AB - Background. The myositis-specific autoantibodies that characterize certain forms of inflammatory myopathy are useful in diagnosing dermatomyositis (DM) / polymyositis and predicting its prognosis. Autoantibodies to small ubiquitin-like modifier activating enzyme (SAE) have been identified as a DM-marker antibody in European Caucasians. Objective and methods. This study investigates the frequency and clinical characteristics of anti-SAE autoantibodies in Japanese patients with DM. Sera from 110 Japanese patients, including 13 with juvenile DM, were screened for anti-SAE antibodies by enzyme-linked immunosorbent assays. Positive sera were further examined by immunoblotting of the immunoprecipitates. Results. Only two patients (1.8%) were confirmed to have anti-SAE antibodies, and neither of these two patients had amyopathic or juvenile DM. One patient with anti-SAE had DM complicated with pulmonary arterial hypertension, and the other had cancer-associated DM. Both had hallmark cutaneous manifestations of DM. Conclusion. This is the first report of anti-SAE antibodies from an Asian single center cohort. Although Japanese patients with anti-SAE antibodies have a clinical phenotype similar to that of Caucasian patients, their frequency was lower in the Japanese patients than in the previously reported Caucasian patients.
UR - http://www.scopus.com/inward/record.url?scp=84877741907&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84877741907&partnerID=8YFLogxK
U2 - 10.3109/08916934.2012.755958
DO - 10.3109/08916934.2012.755958
M3 - Article
C2 - 23215730
AN - SCOPUS:84877741907
VL - 46
SP - 279
EP - 284
JO - Autoimmunity
JF - Autoimmunity
SN - 0891-6934
IS - 4
ER -