TY - JOUR
T1 - Lower LINE-1 methylation is associated with promoter hypermethylation and distinct molecular features in gastric cancer
AU - Tahara, Sayumi
AU - Tahara, Tomomitsu
AU - Horiguchi, Noriyuki
AU - Okubo, Masaaki
AU - Terada, Tsuyoshi
AU - Yoshida, Dai
AU - Funasaka, Kohei
AU - Nakagawa, Yoshihito
AU - Shibata, Tomoyuki
AU - Tsukamoto, Tetsuya
AU - Ohmiya, Naoki
N1 - Publisher Copyright:
© 2019 Future Medicine Ltd.
PY - 2019/11
Y1 - 2019/11
N2 - Aim: To investigate the associations between LINE1 methylation, an indicator for genome-wide hypomethylation, molecular and clinicopathological characteristics of gastric cancer (GC) patients. Patients & methods: LINE1 methylation statuses were examined in paired cancerous, non-neoplastic mucosa from 217 GC and gastric mucosa from separate group of 224 noncancer patients. CpG island methylator phenotype, TP53 and KRAS mutation, MLH1 methylation status and promoter hypermethylation of GC related and H. pylori-related genes were examined. Results: Lower LINE1 methylation was observed in primary GC compared with non-neoplastic gastric mucosa and associated with CpG island methylator phenotype, TP53 mutation, MLH1 methylation and promoter hypermethylation of GC related and H. pylori-related genes. Conclusion: Lower LINE1 methylation correlates specific molecular subtypes and promoter hypermethylation in GC.
AB - Aim: To investigate the associations between LINE1 methylation, an indicator for genome-wide hypomethylation, molecular and clinicopathological characteristics of gastric cancer (GC) patients. Patients & methods: LINE1 methylation statuses were examined in paired cancerous, non-neoplastic mucosa from 217 GC and gastric mucosa from separate group of 224 noncancer patients. CpG island methylator phenotype, TP53 and KRAS mutation, MLH1 methylation status and promoter hypermethylation of GC related and H. pylori-related genes were examined. Results: Lower LINE1 methylation was observed in primary GC compared with non-neoplastic gastric mucosa and associated with CpG island methylator phenotype, TP53 mutation, MLH1 methylation and promoter hypermethylation of GC related and H. pylori-related genes. Conclusion: Lower LINE1 methylation correlates specific molecular subtypes and promoter hypermethylation in GC.
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U2 - 10.2217/epi-2019-0091
DO - 10.2217/epi-2019-0091
M3 - Article
C2 - 31701771
AN - SCOPUS:85075667287
SN - 1750-1911
VL - 11
SP - 1651
EP - 1659
JO - Epigenomics
JF - Epigenomics
IS - 15
ER -
