Lower LINE-1 methylation is associated with promoter hypermethylation and distinct molecular features in gastric cancer

Sayumi Tahara, Tomomitsu Tahara, Noriyuki Horiguchi, Masaaki Okubo, Tsuyoshi Terada, Dai Yoshida, Kohei Funasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Tetsuya Tsukamoto, Naoki Ohmiya

Research output: Contribution to journalArticle

Abstract

Aim: To investigate the associations between LINE1 methylation, an indicator for genome-wide hypomethylation, molecular and clinicopathological characteristics of gastric cancer (GC) patients. Patients & methods: LINE1 methylation statuses were examined in paired cancerous, non-neoplastic mucosa from 217 GC and gastric mucosa from separate group of 224 noncancer patients. CpG island methylator phenotype, TP53 and KRAS mutation, MLH1 methylation status and promoter hypermethylation of GC related and H. pylori-related genes were examined. Results: Lower LINE1 methylation was observed in primary GC compared with non-neoplastic gastric mucosa and associated with CpG island methylator phenotype, TP53 mutation, MLH1 methylation and promoter hypermethylation of GC related and H. pylori-related genes. Conclusion: Lower LINE1 methylation correlates specific molecular subtypes and promoter hypermethylation in GC.

Original languageEnglish
Pages (from-to)1651-1659
Number of pages9
JournalEpigenomics
Volume11
Issue number15
DOIs
Publication statusPublished - 11-2019

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All Science Journal Classification (ASJC) codes

  • Genetics
  • Cancer Research

Cite this

Tahara, S., Tahara, T., Horiguchi, N., Okubo, M., Terada, T., Yoshida, D., Funasaka, K., Nakagawa, Y., Shibata, T., Tsukamoto, T., & Ohmiya, N. (2019). Lower LINE-1 methylation is associated with promoter hypermethylation and distinct molecular features in gastric cancer. Epigenomics, 11(15), 1651-1659. https://doi.org/10.2217/epi-2019-0091