Lowering barometric pressure aggravates mechanical allodynia and hyperalgesia in a rat model of neuropathic pain

Jun Sato; Hirohumi Morimae; Yusuke Seino; Taku Kobayashi; Noriyuki Suzuki; Kazue Mizumura

doi:10.1016/S0304-3940(99)00260-8

Lowering barometric pressure aggravates mechanical allodynia and hyperalgesia in a rat model of neuropathic pain

Jun Sato
, Hirohumi Morimae
, Yusuke Seino
, Taku Kobayashi
, Noriyuki Suzuki
, Kazue Mizumura

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

To examine the effects of meteorological change on the pain-related behaviors of neuropathic rats, animals with a chronic Constriction injury (CCI) to the sciatic nerve were exposed to low barometric pressure (LP), 20 mmHg below the natural atmospheric pressure in a climate-controlled room. CCI caused a decreased hindpaw withdrawal threshold to yon Frey hair (VFH) stimulation (mechanical allodynia) and prolonged duration of hindpaw withdrawal in response to pinprick stimulation (mechanical hyperalgesia). When the CCI rats were exposed to LP, both these pain-related behaviors were aggravated, whereas no change was seen in a group of controls. In the CCI rats sympathectomy inhibited this LP-induced augmentation of pain-related behaviors. These results show that LP intensifies the abnormalities in the pain-related behaviors of neuropathic rats, and that sympathetic activity contributes to the LP effect.

Original language	English
Pages (from-to)	21-24
Number of pages	4
Journal	Neuroscience Letters
Volume	266
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(99)00260-8
Publication status	Published - 30-04-1999
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 13 Climate Action

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1016/S0304-3940(99)00260-8

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title = "Lowering barometric pressure aggravates mechanical allodynia and hyperalgesia in a rat model of neuropathic pain",

abstract = "To examine the effects of meteorological change on the pain-related behaviors of neuropathic rats, animals with a chronic Constriction injury (CCI) to the sciatic nerve were exposed to low barometric pressure (LP), 20 mmHg below the natural atmospheric pressure in a climate-controlled room. CCI caused a decreased hindpaw withdrawal threshold to yon Frey hair (VFH) stimulation (mechanical allodynia) and prolonged duration of hindpaw withdrawal in response to pinprick stimulation (mechanical hyperalgesia). When the CCI rats were exposed to LP, both these pain-related behaviors were aggravated, whereas no change was seen in a group of controls. In the CCI rats sympathectomy inhibited this LP-induced augmentation of pain-related behaviors. These results show that LP intensifies the abnormalities in the pain-related behaviors of neuropathic rats, and that sympathetic activity contributes to the LP effect.",

author = "Jun Sato and Hirohumi Morimae and Yusuke Seino and Taku Kobayashi and Noriyuki Suzuki and Kazue Mizumura",

note = "Funding Information: We thank Dr. K. Koga and Mr. Y. Ota for their technical assistance, and thank Drs. G.J. Bennett and T. Kumazawa for their valuable comments on the manuscript. This work was partly supported by Grants-in-Aid for Scientific Research from the Japanese Ministry of Education, Science and Culture, the Kato Ryutaro Foundation at Nagoya University and a part of {\textquoteleft}Ground Research for Space Utilization{\textquoteright} promoted by NASDA and The Japan Space Forum.",

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doi = "10.1016/S0304-3940(99)00260-8",

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AU - Sato, Jun

AU - Morimae, Hirohumi

AU - Seino, Yusuke

AU - Kobayashi, Taku

AU - Suzuki, Noriyuki

AU - Mizumura, Kazue

N1 - Funding Information: We thank Dr. K. Koga and Mr. Y. Ota for their technical assistance, and thank Drs. G.J. Bennett and T. Kumazawa for their valuable comments on the manuscript. This work was partly supported by Grants-in-Aid for Scientific Research from the Japanese Ministry of Education, Science and Culture, the Kato Ryutaro Foundation at Nagoya University and a part of ‘Ground Research for Space Utilization’ promoted by NASDA and The Japan Space Forum.

PY - 1999/4/30

Y1 - 1999/4/30

N2 - To examine the effects of meteorological change on the pain-related behaviors of neuropathic rats, animals with a chronic Constriction injury (CCI) to the sciatic nerve were exposed to low barometric pressure (LP), 20 mmHg below the natural atmospheric pressure in a climate-controlled room. CCI caused a decreased hindpaw withdrawal threshold to yon Frey hair (VFH) stimulation (mechanical allodynia) and prolonged duration of hindpaw withdrawal in response to pinprick stimulation (mechanical hyperalgesia). When the CCI rats were exposed to LP, both these pain-related behaviors were aggravated, whereas no change was seen in a group of controls. In the CCI rats sympathectomy inhibited this LP-induced augmentation of pain-related behaviors. These results show that LP intensifies the abnormalities in the pain-related behaviors of neuropathic rats, and that sympathetic activity contributes to the LP effect.

AB - To examine the effects of meteorological change on the pain-related behaviors of neuropathic rats, animals with a chronic Constriction injury (CCI) to the sciatic nerve were exposed to low barometric pressure (LP), 20 mmHg below the natural atmospheric pressure in a climate-controlled room. CCI caused a decreased hindpaw withdrawal threshold to yon Frey hair (VFH) stimulation (mechanical allodynia) and prolonged duration of hindpaw withdrawal in response to pinprick stimulation (mechanical hyperalgesia). When the CCI rats were exposed to LP, both these pain-related behaviors were aggravated, whereas no change was seen in a group of controls. In the CCI rats sympathectomy inhibited this LP-induced augmentation of pain-related behaviors. These results show that LP intensifies the abnormalities in the pain-related behaviors of neuropathic rats, and that sympathetic activity contributes to the LP effect.

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Lowering barometric pressure aggravates mechanical allodynia and hyperalgesia in a rat model of neuropathic pain

Abstract

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