Lung cancer mortality and serum levels of carotenoids, retinol, tocopherols, and folic acid in men and women: A case-control study nested in the JACC study

Yoshinori Ito, Kenji Wakai, Koji Suzuki, Kotaro Ozasa, Yoshiyuki Watanabe, Nao Seki, Masahiko Ando, Yoshikazu Nishino, Takaaki Kondo, Yoshiyuki Ohno, Akiko Tamakoshi, Mitsuru Mori, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Yutaka Inaba, Yoshiharu Hoshiyama, Hiroshi SuzukiHiroyuki Shimizu, Hideaki Toyoshima, Shinkan Tokudome, Shuji Hashimoto, Shogo Kikuchi, Akio Koizumi, Takashi Kawamura, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Takayuki Nose, Norihiko Hayakawa, Takesumi Yoshimura, Akira Shibata, Naoyuki Okamoto, Hideo Shio, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tajima

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background: Lung cancer mortality is inversely associated with high serum carotenoid levels and high intake of vegetables and fruits rich in carotenoids. The Japan Collaborative Cohort (JACC) Study was conducted to investigate whether serum levels of carotenoids, retinol, tocopherols, and folic acid were associated with risk for lung cancer death with follow-up through 1997. To examine the association by sex, we extended the follow-up and analyzed additional serum samples. Methods: In the JACC Study, 39,242 subjects provided serum samples at baseline between 1988 and 1990. We identified 211 cases (163 men and 48 women) of death from lung cancer during about 10-year follow-up ending in 1999. Of the subjects who survived to the end of that follow-up, 487 controls (375 men and 112 women) were selected, and were matched to each case of lung cancer death for sex, age and participating institution. We measured serum levels of antioxidants in cases of lung cancer death and controls. Odds ratio (OR) for lung cancer death was estimated using conditional logistic models by sex. Results: For men, the risk of lung cancer death was significantly lower for the highest quartile of serum α- and β-carotenes, lycopene, and β-cryptoxanthin than for the lowest quartile: the OR adjusted for smoking and other covariates were 0.41, 0.28, 0.46, and 0.39, respectively. For women, serum levels of α-carotene and zeaxanthin/lutein were inversely associated with risk of lung cancer, but the association was not significant. No association between lung cancer and serum levels of β-carotene, β-cryptoxanthin, and retinol was appeared among women. There was a suggestion that association between lung cancer and high serum levels of these components might differ between men and women. Conclusions: Higher serum levels of carotenoids appear to play a role in preventing death from lung cancer among Japanese men. Relationships between lung cancer and serum levels of some carotenoids appear to differ between sexes, However, further study with a large number of women cases needs to clarify the discrepancy between sexes.

Original languageEnglish
JournalJournal of epidemiology
Volume15
Issue numberSUPPL. 2
DOIs
Publication statusPublished - 14-10-2005

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Tocopherols
Carotenoids
Vitamin A
Folic Acid
Case-Control Studies
Lung Neoplasms
Japan
Cohort Studies
Mortality
Serum
Odds Ratio
Lutein
Vegetables
Fruit
Antioxidants
Logistic Models
Smoking

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Ito, Yoshinori ; Wakai, Kenji ; Suzuki, Koji ; Ozasa, Kotaro ; Watanabe, Yoshiyuki ; Seki, Nao ; Ando, Masahiko ; Nishino, Yoshikazu ; Kondo, Takaaki ; Ohno, Yoshiyuki ; Tamakoshi, Akiko ; Mori, Mitsuru ; Motohashi, Yutaka ; Tsuji, Ichiro ; Nakamura, Yosikazu ; Iso, Hiroyasu ; Mikami, Haruo ; Inaba, Yutaka ; Hoshiyama, Yoshiharu ; Suzuki, Hiroshi ; Shimizu, Hiroyuki ; Toyoshima, Hideaki ; Tokudome, Shinkan ; Hashimoto, Shuji ; Kikuchi, Shogo ; Koizumi, Akio ; Kawamura, Takashi ; Miki, Tsuneharu ; Date, Chigusa ; Sakata, Kiyomi ; Nose, Takayuki ; Hayakawa, Norihiko ; Yoshimura, Takesumi ; Shibata, Akira ; Okamoto, Naoyuki ; Shio, Hideo ; Kitagawa, Tomoyuki ; Kuroki, Toshio ; Tajima, Kazuo. / Lung cancer mortality and serum levels of carotenoids, retinol, tocopherols, and folic acid in men and women : A case-control study nested in the JACC study. In: Journal of epidemiology. 2005 ; Vol. 15, No. SUPPL. 2.
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title = "Lung cancer mortality and serum levels of carotenoids, retinol, tocopherols, and folic acid in men and women: A case-control study nested in the JACC study",
abstract = "Background: Lung cancer mortality is inversely associated with high serum carotenoid levels and high intake of vegetables and fruits rich in carotenoids. The Japan Collaborative Cohort (JACC) Study was conducted to investigate whether serum levels of carotenoids, retinol, tocopherols, and folic acid were associated with risk for lung cancer death with follow-up through 1997. To examine the association by sex, we extended the follow-up and analyzed additional serum samples. Methods: In the JACC Study, 39,242 subjects provided serum samples at baseline between 1988 and 1990. We identified 211 cases (163 men and 48 women) of death from lung cancer during about 10-year follow-up ending in 1999. Of the subjects who survived to the end of that follow-up, 487 controls (375 men and 112 women) were selected, and were matched to each case of lung cancer death for sex, age and participating institution. We measured serum levels of antioxidants in cases of lung cancer death and controls. Odds ratio (OR) for lung cancer death was estimated using conditional logistic models by sex. Results: For men, the risk of lung cancer death was significantly lower for the highest quartile of serum α- and β-carotenes, lycopene, and β-cryptoxanthin than for the lowest quartile: the OR adjusted for smoking and other covariates were 0.41, 0.28, 0.46, and 0.39, respectively. For women, serum levels of α-carotene and zeaxanthin/lutein were inversely associated with risk of lung cancer, but the association was not significant. No association between lung cancer and serum levels of β-carotene, β-cryptoxanthin, and retinol was appeared among women. There was a suggestion that association between lung cancer and high serum levels of these components might differ between men and women. Conclusions: Higher serum levels of carotenoids appear to play a role in preventing death from lung cancer among Japanese men. Relationships between lung cancer and serum levels of some carotenoids appear to differ between sexes, However, further study with a large number of women cases needs to clarify the discrepancy between sexes.",
author = "Yoshinori Ito and Kenji Wakai and Koji Suzuki and Kotaro Ozasa and Yoshiyuki Watanabe and Nao Seki and Masahiko Ando and Yoshikazu Nishino and Takaaki Kondo and Yoshiyuki Ohno and Akiko Tamakoshi and Mitsuru Mori and Yutaka Motohashi and Ichiro Tsuji and Yosikazu Nakamura and Hiroyasu Iso and Haruo Mikami and Yutaka Inaba and Yoshiharu Hoshiyama and Hiroshi Suzuki and Hiroyuki Shimizu and Hideaki Toyoshima and Shinkan Tokudome and Shuji Hashimoto and Shogo Kikuchi and Akio Koizumi and Takashi Kawamura and Tsuneharu Miki and Chigusa Date and Kiyomi Sakata and Takayuki Nose and Norihiko Hayakawa and Takesumi Yoshimura and Akira Shibata and Naoyuki Okamoto and Hideo Shio and Tomoyuki Kitagawa and Toshio Kuroki and Kazuo Tajima",
year = "2005",
month = "10",
day = "14",
doi = "10.2188/jea.15.S140",
language = "English",
volume = "15",
journal = "Journal of Epidemiology",
issn = "0917-5040",
publisher = "Japan Epidemiology Association",
number = "SUPPL. 2",

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Ito, Y, Wakai, K, Suzuki, K, Ozasa, K, Watanabe, Y, Seki, N, Ando, M, Nishino, Y, Kondo, T, Ohno, Y, Tamakoshi, A, Mori, M, Motohashi, Y, Tsuji, I, Nakamura, Y, Iso, H, Mikami, H, Inaba, Y, Hoshiyama, Y, Suzuki, H, Shimizu, H, Toyoshima, H, Tokudome, S, Hashimoto, S, Kikuchi, S, Koizumi, A, Kawamura, T, Miki, T, Date, C, Sakata, K, Nose, T, Hayakawa, N, Yoshimura, T, Shibata, A, Okamoto, N, Shio, H, Kitagawa, T, Kuroki, T & Tajima, K 2005, 'Lung cancer mortality and serum levels of carotenoids, retinol, tocopherols, and folic acid in men and women: A case-control study nested in the JACC study', Journal of epidemiology, vol. 15, no. SUPPL. 2. https://doi.org/10.2188/jea.15.S140

Lung cancer mortality and serum levels of carotenoids, retinol, tocopherols, and folic acid in men and women : A case-control study nested in the JACC study. / Ito, Yoshinori; Wakai, Kenji; Suzuki, Koji; Ozasa, Kotaro; Watanabe, Yoshiyuki; Seki, Nao; Ando, Masahiko; Nishino, Yoshikazu; Kondo, Takaaki; Ohno, Yoshiyuki; Tamakoshi, Akiko; Mori, Mitsuru; Motohashi, Yutaka; Tsuji, Ichiro; Nakamura, Yosikazu; Iso, Hiroyasu; Mikami, Haruo; Inaba, Yutaka; Hoshiyama, Yoshiharu; Suzuki, Hiroshi; Shimizu, Hiroyuki; Toyoshima, Hideaki; Tokudome, Shinkan; Hashimoto, Shuji; Kikuchi, Shogo; Koizumi, Akio; Kawamura, Takashi; Miki, Tsuneharu; Date, Chigusa; Sakata, Kiyomi; Nose, Takayuki; Hayakawa, Norihiko; Yoshimura, Takesumi; Shibata, Akira; Okamoto, Naoyuki; Shio, Hideo; Kitagawa, Tomoyuki; Kuroki, Toshio; Tajima, Kazuo.

In: Journal of epidemiology, Vol. 15, No. SUPPL. 2, 14.10.2005.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Lung cancer mortality and serum levels of carotenoids, retinol, tocopherols, and folic acid in men and women

T2 - A case-control study nested in the JACC study

AU - Ito, Yoshinori

AU - Wakai, Kenji

AU - Suzuki, Koji

AU - Ozasa, Kotaro

AU - Watanabe, Yoshiyuki

AU - Seki, Nao

AU - Ando, Masahiko

AU - Nishino, Yoshikazu

AU - Kondo, Takaaki

AU - Ohno, Yoshiyuki

AU - Tamakoshi, Akiko

AU - Mori, Mitsuru

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Haruo

AU - Inaba, Yutaka

AU - Hoshiyama, Yoshiharu

AU - Suzuki, Hiroshi

AU - Shimizu, Hiroyuki

AU - Toyoshima, Hideaki

AU - Tokudome, Shinkan

AU - Hashimoto, Shuji

AU - Kikuchi, Shogo

AU - Koizumi, Akio

AU - Kawamura, Takashi

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Nose, Takayuki

AU - Hayakawa, Norihiko

AU - Yoshimura, Takesumi

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

AU - Kitagawa, Tomoyuki

AU - Kuroki, Toshio

AU - Tajima, Kazuo

PY - 2005/10/14

Y1 - 2005/10/14

N2 - Background: Lung cancer mortality is inversely associated with high serum carotenoid levels and high intake of vegetables and fruits rich in carotenoids. The Japan Collaborative Cohort (JACC) Study was conducted to investigate whether serum levels of carotenoids, retinol, tocopherols, and folic acid were associated with risk for lung cancer death with follow-up through 1997. To examine the association by sex, we extended the follow-up and analyzed additional serum samples. Methods: In the JACC Study, 39,242 subjects provided serum samples at baseline between 1988 and 1990. We identified 211 cases (163 men and 48 women) of death from lung cancer during about 10-year follow-up ending in 1999. Of the subjects who survived to the end of that follow-up, 487 controls (375 men and 112 women) were selected, and were matched to each case of lung cancer death for sex, age and participating institution. We measured serum levels of antioxidants in cases of lung cancer death and controls. Odds ratio (OR) for lung cancer death was estimated using conditional logistic models by sex. Results: For men, the risk of lung cancer death was significantly lower for the highest quartile of serum α- and β-carotenes, lycopene, and β-cryptoxanthin than for the lowest quartile: the OR adjusted for smoking and other covariates were 0.41, 0.28, 0.46, and 0.39, respectively. For women, serum levels of α-carotene and zeaxanthin/lutein were inversely associated with risk of lung cancer, but the association was not significant. No association between lung cancer and serum levels of β-carotene, β-cryptoxanthin, and retinol was appeared among women. There was a suggestion that association between lung cancer and high serum levels of these components might differ between men and women. Conclusions: Higher serum levels of carotenoids appear to play a role in preventing death from lung cancer among Japanese men. Relationships between lung cancer and serum levels of some carotenoids appear to differ between sexes, However, further study with a large number of women cases needs to clarify the discrepancy between sexes.

AB - Background: Lung cancer mortality is inversely associated with high serum carotenoid levels and high intake of vegetables and fruits rich in carotenoids. The Japan Collaborative Cohort (JACC) Study was conducted to investigate whether serum levels of carotenoids, retinol, tocopherols, and folic acid were associated with risk for lung cancer death with follow-up through 1997. To examine the association by sex, we extended the follow-up and analyzed additional serum samples. Methods: In the JACC Study, 39,242 subjects provided serum samples at baseline between 1988 and 1990. We identified 211 cases (163 men and 48 women) of death from lung cancer during about 10-year follow-up ending in 1999. Of the subjects who survived to the end of that follow-up, 487 controls (375 men and 112 women) were selected, and were matched to each case of lung cancer death for sex, age and participating institution. We measured serum levels of antioxidants in cases of lung cancer death and controls. Odds ratio (OR) for lung cancer death was estimated using conditional logistic models by sex. Results: For men, the risk of lung cancer death was significantly lower for the highest quartile of serum α- and β-carotenes, lycopene, and β-cryptoxanthin than for the lowest quartile: the OR adjusted for smoking and other covariates were 0.41, 0.28, 0.46, and 0.39, respectively. For women, serum levels of α-carotene and zeaxanthin/lutein were inversely associated with risk of lung cancer, but the association was not significant. No association between lung cancer and serum levels of β-carotene, β-cryptoxanthin, and retinol was appeared among women. There was a suggestion that association between lung cancer and high serum levels of these components might differ between men and women. Conclusions: Higher serum levels of carotenoids appear to play a role in preventing death from lung cancer among Japanese men. Relationships between lung cancer and serum levels of some carotenoids appear to differ between sexes, However, further study with a large number of women cases needs to clarify the discrepancy between sexes.

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