Lymphatic vessels develop during tubulointerstitial fibrosis

Izumi Sakamoto, Yasuhiko Ito, Masashi Mizuno, Yasuhiro Suzuki, Akiho Sawai, Akio Tanaka, Shoichi Maruyama, Yoshifumi Takei, Yukio Yuzawa, Seiichi Matsuo

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Recent progress with specific markers of lymphatic vessel endothelium allowed recognition of lymphangiogenic events in various disease states; however, there is little information concerning this process in human chronic renal diseases. To determine this we measured expression of the lymphatic marker D2-40 and vascular endothelial growth factor-C (VEGF-C), a major growth factor in lymphangiogenesis, in 124 human renal biopsy specimens. In the kidneys of control subjects and in uninjured areas of pathologic specimens, lymphatic vessels were detected only around the arcuate and interlobular arteries. An increase in the number of lymphatic vessels was found at the site of tubulointerstitial lesions correlating with the degree of tissue damage and more strongly correlating with areas of fibrosis than inflammation. On serial sections, lymphatic vessel proliferation was found in the tubulointerstitial area at the site of tuft adhesions to Bowman's capsule. Lymphatic growth was associated with VEGF-C expression in inflammatory mononuclear cells and tubular epithelial cells, mainly of proximal tubules. Lymphangiogenesis and VEGF-C expression was elevated in diabetic nephropathy in comparison to other renal diseases. Our results indicate that lymphangiogenesis is a common feature in the progression of the tubulointerstitial fibrosis.

Original languageEnglish
Pages (from-to)828-838
Number of pages11
JournalKidney International
Volume75
Issue number8
DOIs
Publication statusPublished - 01-04-2009
Externally publishedYes

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Lymphatic Vessels
Lymphangiogenesis
Vascular Endothelial Growth Factor C
Fibrosis
Kidney
Lymphatic Endothelium
Bowman Capsule
Diabetic Nephropathies
Chronic Renal Insufficiency
Intercellular Signaling Peptides and Proteins
Arteries
Epithelial Cells
Inflammation
Biopsy
Growth

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Sakamoto, I., Ito, Y., Mizuno, M., Suzuki, Y., Sawai, A., Tanaka, A., ... Matsuo, S. (2009). Lymphatic vessels develop during tubulointerstitial fibrosis. Kidney International, 75(8), 828-838. https://doi.org/10.1038/ki.2008.661
Sakamoto, Izumi ; Ito, Yasuhiko ; Mizuno, Masashi ; Suzuki, Yasuhiro ; Sawai, Akiho ; Tanaka, Akio ; Maruyama, Shoichi ; Takei, Yoshifumi ; Yuzawa, Yukio ; Matsuo, Seiichi. / Lymphatic vessels develop during tubulointerstitial fibrosis. In: Kidney International. 2009 ; Vol. 75, No. 8. pp. 828-838.
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Sakamoto, I, Ito, Y, Mizuno, M, Suzuki, Y, Sawai, A, Tanaka, A, Maruyama, S, Takei, Y, Yuzawa, Y & Matsuo, S 2009, 'Lymphatic vessels develop during tubulointerstitial fibrosis', Kidney International, vol. 75, no. 8, pp. 828-838. https://doi.org/10.1038/ki.2008.661

Lymphatic vessels develop during tubulointerstitial fibrosis. / Sakamoto, Izumi; Ito, Yasuhiko; Mizuno, Masashi; Suzuki, Yasuhiro; Sawai, Akiho; Tanaka, Akio; Maruyama, Shoichi; Takei, Yoshifumi; Yuzawa, Yukio; Matsuo, Seiichi.

In: Kidney International, Vol. 75, No. 8, 01.04.2009, p. 828-838.

Research output: Contribution to journalArticle

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Sakamoto I, Ito Y, Mizuno M, Suzuki Y, Sawai A, Tanaka A et al. Lymphatic vessels develop during tubulointerstitial fibrosis. Kidney International. 2009 Apr 1;75(8):828-838. https://doi.org/10.1038/ki.2008.661