Lymphoid Cell Subpopulations Infiltrating into Autologous Rat Tumors Undergoing Rejection

Yoshifumi Ishii, Akihiro Matsuura, Tsuyoshi Takami, Teiji Uede, Yukihiro Ibayashi, Toshimitsu Uede, Masakatsu Imamura, Kokichi Kikuchi, Yuko Kikuchi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Lymphoid cell subpopulations infiltrating into autografts of methylcholanthrene-induced sarcomas in rats immunized with autologous tumor cells were identified in terms of immunohisto-chemical and cytofluorographic techniques using various monoclonal antibodies raised against different classes of rat lympho-hemopoietic cells. These antibodies included in this study directed to rat T-cell antigens corresponding to mouse Lyt-1 (RLyt-1) and Lyt-2,3 antigens (RLyt-2) and to W3/25 antigen expressed on a particular subset of rat T-cells with helper function, as well as to rat granulocyte-macrophage-specific antigen (RGM-1). Histological studies demonstrated that the autografts of highly antigenic tumors introduced to the primary hosts were completely rejected following massive immigration of lymphoid cells into the tumor sites, which was not observed in progressively growing, minimally antigenic tumors. These lymphoid cells found within regressing highly antigenic tumor autografts were identified mostly to be T-cells bearing RLyt-1 (approximately 70%), and more than two-thirds of these T-cells expressed RLyt-2 antigen. In contrast to T-cells, macrophages and B-cells, each of which could be recognized by the presence of either RGM-1 antigen or immunoglobulin on their cell surfaces, appeared to have a minimal role in the rejection of autochthonous tumors, as reflected by their less frequent appearance within the tumor tissues during the rejection process.

Original languageEnglish
Pages (from-to)4053-4058
Number of pages6
JournalCancer Research
Volume44
Issue number9
Publication statusPublished - 01-09-1984

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Lymphocytes
Antigens
Autografts
Neoplasms
T-Lymphocytes
Macrophages
Methylcholanthrene
Viral Tumor Antigens
Emigration and Immigration
T-Lymphocyte Subsets
Helper-Inducer T-Lymphocytes
Granulocytes
Sarcoma
Immunoglobulins
B-Lymphocytes
Monoclonal Antibodies
Antibodies

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Ishii, Y., Matsuura, A., Takami, T., Uede, T., Ibayashi, Y., Uede, T., ... Kikuchi, Y. (1984). Lymphoid Cell Subpopulations Infiltrating into Autologous Rat Tumors Undergoing Rejection. Cancer Research, 44(9), 4053-4058.
Ishii, Yoshifumi ; Matsuura, Akihiro ; Takami, Tsuyoshi ; Uede, Teiji ; Ibayashi, Yukihiro ; Uede, Toshimitsu ; Imamura, Masakatsu ; Kikuchi, Kokichi ; Kikuchi, Yuko. / Lymphoid Cell Subpopulations Infiltrating into Autologous Rat Tumors Undergoing Rejection. In: Cancer Research. 1984 ; Vol. 44, No. 9. pp. 4053-4058.
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abstract = "Lymphoid cell subpopulations infiltrating into autografts of methylcholanthrene-induced sarcomas in rats immunized with autologous tumor cells were identified in terms of immunohisto-chemical and cytofluorographic techniques using various monoclonal antibodies raised against different classes of rat lympho-hemopoietic cells. These antibodies included in this study directed to rat T-cell antigens corresponding to mouse Lyt-1 (RLyt-1) and Lyt-2,3 antigens (RLyt-2) and to W3/25 antigen expressed on a particular subset of rat T-cells with helper function, as well as to rat granulocyte-macrophage-specific antigen (RGM-1). Histological studies demonstrated that the autografts of highly antigenic tumors introduced to the primary hosts were completely rejected following massive immigration of lymphoid cells into the tumor sites, which was not observed in progressively growing, minimally antigenic tumors. These lymphoid cells found within regressing highly antigenic tumor autografts were identified mostly to be T-cells bearing RLyt-1 (approximately 70{\%}), and more than two-thirds of these T-cells expressed RLyt-2 antigen. In contrast to T-cells, macrophages and B-cells, each of which could be recognized by the presence of either RGM-1 antigen or immunoglobulin on their cell surfaces, appeared to have a minimal role in the rejection of autochthonous tumors, as reflected by their less frequent appearance within the tumor tissues during the rejection process.",
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Ishii, Y, Matsuura, A, Takami, T, Uede, T, Ibayashi, Y, Uede, T, Imamura, M, Kikuchi, K & Kikuchi, Y 1984, 'Lymphoid Cell Subpopulations Infiltrating into Autologous Rat Tumors Undergoing Rejection', Cancer Research, vol. 44, no. 9, pp. 4053-4058.

Lymphoid Cell Subpopulations Infiltrating into Autologous Rat Tumors Undergoing Rejection. / Ishii, Yoshifumi; Matsuura, Akihiro; Takami, Tsuyoshi; Uede, Teiji; Ibayashi, Yukihiro; Uede, Toshimitsu; Imamura, Masakatsu; Kikuchi, Kokichi; Kikuchi, Yuko.

In: Cancer Research, Vol. 44, No. 9, 01.09.1984, p. 4053-4058.

Research output: Contribution to journalArticle

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AB - Lymphoid cell subpopulations infiltrating into autografts of methylcholanthrene-induced sarcomas in rats immunized with autologous tumor cells were identified in terms of immunohisto-chemical and cytofluorographic techniques using various monoclonal antibodies raised against different classes of rat lympho-hemopoietic cells. These antibodies included in this study directed to rat T-cell antigens corresponding to mouse Lyt-1 (RLyt-1) and Lyt-2,3 antigens (RLyt-2) and to W3/25 antigen expressed on a particular subset of rat T-cells with helper function, as well as to rat granulocyte-macrophage-specific antigen (RGM-1). Histological studies demonstrated that the autografts of highly antigenic tumors introduced to the primary hosts were completely rejected following massive immigration of lymphoid cells into the tumor sites, which was not observed in progressively growing, minimally antigenic tumors. These lymphoid cells found within regressing highly antigenic tumor autografts were identified mostly to be T-cells bearing RLyt-1 (approximately 70%), and more than two-thirds of these T-cells expressed RLyt-2 antigen. In contrast to T-cells, macrophages and B-cells, each of which could be recognized by the presence of either RGM-1 antigen or immunoglobulin on their cell surfaces, appeared to have a minimal role in the rejection of autochthonous tumors, as reflected by their less frequent appearance within the tumor tissues during the rejection process.

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Ishii Y, Matsuura A, Takami T, Uede T, Ibayashi Y, Uede T et al. Lymphoid Cell Subpopulations Infiltrating into Autologous Rat Tumors Undergoing Rejection. Cancer Research. 1984 Sep 1;44(9):4053-4058.