Macronutrient intakes and serum oestrogen, and interaction with polymorphisms in CYP19A1 and HSD17B1 genes: A cross-sectional study in postmenopausal Japanese women

Sahoko Takagi, Mariko Naito, Sayo Kawai, Rieko Okada, Chisato Nagata, Satoyo Hosono, Yuichiro Nishida, Naoyuki Takashima, Sadao Suzuki, Ippei Shimoshikiryo, Haruo Mikami, Hirokazu Uemura, Nagato Kuriyama, Keizo Ohnaka, Michiaki Kubo, Nobuyuki Hamajima, Hideo Tanaka, Kenji Wakai

Research output: Contribution to journalArticle

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Abstract

Although higher circulating levels of oestrogen are related to postmenopausal breast cancer risk, limited information is available regarding effects of diet on endogenous oestrogen. Thus, we examined associations between macronutrient intakes and serum oestrogen with consideration of polymorphisms in oestrogen-metabolising genes. In this cross-sectional study, 784 naturally menopaused Japanese women aged 47-69 years were selected from participants of the Japan Multi-Institutional Collaborative Cohort Study. We documented dietary intakes, measured serum concentrations of oestrone (E1) and oestradiol (E2) and genotyped polymorphisms in oestrogen-metabolising CYP19A1 (rs4441215 and rs936306) and HSD17B1 (rs605059) genes. Trends and interactions were examined using linear regression models. In addition, we calculated the ratios of the oestrogen concentrations of the second to the highest quartiles (Q2-Q4) of dietary intake to those of the lowest quartiles (Q1). After adjustment for potential confounders, E2 was significantly associated with intake of carbohydrate and noodles; ratios of Q4 v. Q1 were 1·15 (95 % CI 1·04, 1·28) and 1·15 (95 % CI 1·04, 1·26), respectively. In contrast, E2 levels were inversely associated with intake of total energy, SFA and n-3 highly unsaturated fatty acids (n-3 HUFA); ratios of Q4 v. Q1 were 0·90 (95 % CI 0·82, 0·99), 0·89 (95 % CI 0·81, 0·98) and 0·91 (95 % CI 0·83, 1·00), respectively. In stratified analysis by polymorphisms, the rs605059 genotype of HSD17B1 significantly modified associations of E2 with intake of n-3 HUFA and fish; the associations were limited to those with the CC genotype. Macronutrient intakes were associated with serum E2 level, and these associations may be modified by HSD17B1 polymorphism in postmenopausal women.

Original languageEnglish
Pages (from-to)463-472
Number of pages10
JournalBritish Journal of Nutrition
Volume118
Issue number6
DOIs
Publication statusPublished - 28-09-2017

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Estrogens
Cross-Sectional Studies
Serum
Genes
Unsaturated Fatty Acids
Linear Models
Genotype
Estrone
Energy Intake
Estradiol
Japan
Fishes
Cohort Studies
Carbohydrates
Breast Neoplasms
Diet

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Takagi, Sahoko ; Naito, Mariko ; Kawai, Sayo ; Okada, Rieko ; Nagata, Chisato ; Hosono, Satoyo ; Nishida, Yuichiro ; Takashima, Naoyuki ; Suzuki, Sadao ; Shimoshikiryo, Ippei ; Mikami, Haruo ; Uemura, Hirokazu ; Kuriyama, Nagato ; Ohnaka, Keizo ; Kubo, Michiaki ; Hamajima, Nobuyuki ; Tanaka, Hideo ; Wakai, Kenji. / Macronutrient intakes and serum oestrogen, and interaction with polymorphisms in CYP19A1 and HSD17B1 genes : A cross-sectional study in postmenopausal Japanese women. In: British Journal of Nutrition. 2017 ; Vol. 118, No. 6. pp. 463-472.
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abstract = "Although higher circulating levels of oestrogen are related to postmenopausal breast cancer risk, limited information is available regarding effects of diet on endogenous oestrogen. Thus, we examined associations between macronutrient intakes and serum oestrogen with consideration of polymorphisms in oestrogen-metabolising genes. In this cross-sectional study, 784 naturally menopaused Japanese women aged 47-69 years were selected from participants of the Japan Multi-Institutional Collaborative Cohort Study. We documented dietary intakes, measured serum concentrations of oestrone (E1) and oestradiol (E2) and genotyped polymorphisms in oestrogen-metabolising CYP19A1 (rs4441215 and rs936306) and HSD17B1 (rs605059) genes. Trends and interactions were examined using linear regression models. In addition, we calculated the ratios of the oestrogen concentrations of the second to the highest quartiles (Q2-Q4) of dietary intake to those of the lowest quartiles (Q1). After adjustment for potential confounders, E2 was significantly associated with intake of carbohydrate and noodles; ratios of Q4 v. Q1 were 1·15 (95 {\%} CI 1·04, 1·28) and 1·15 (95 {\%} CI 1·04, 1·26), respectively. In contrast, E2 levels were inversely associated with intake of total energy, SFA and n-3 highly unsaturated fatty acids (n-3 HUFA); ratios of Q4 v. Q1 were 0·90 (95 {\%} CI 0·82, 0·99), 0·89 (95 {\%} CI 0·81, 0·98) and 0·91 (95 {\%} CI 0·83, 1·00), respectively. In stratified analysis by polymorphisms, the rs605059 genotype of HSD17B1 significantly modified associations of E2 with intake of n-3 HUFA and fish; the associations were limited to those with the CC genotype. Macronutrient intakes were associated with serum E2 level, and these associations may be modified by HSD17B1 polymorphism in postmenopausal women.",
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Takagi, S, Naito, M, Kawai, S, Okada, R, Nagata, C, Hosono, S, Nishida, Y, Takashima, N, Suzuki, S, Shimoshikiryo, I, Mikami, H, Uemura, H, Kuriyama, N, Ohnaka, K, Kubo, M, Hamajima, N, Tanaka, H & Wakai, K 2017, 'Macronutrient intakes and serum oestrogen, and interaction with polymorphisms in CYP19A1 and HSD17B1 genes: A cross-sectional study in postmenopausal Japanese women', British Journal of Nutrition, vol. 118, no. 6, pp. 463-472. https://doi.org/10.1017/S0007114517002239

Macronutrient intakes and serum oestrogen, and interaction with polymorphisms in CYP19A1 and HSD17B1 genes : A cross-sectional study in postmenopausal Japanese women. / Takagi, Sahoko; Naito, Mariko; Kawai, Sayo; Okada, Rieko; Nagata, Chisato; Hosono, Satoyo; Nishida, Yuichiro; Takashima, Naoyuki; Suzuki, Sadao; Shimoshikiryo, Ippei; Mikami, Haruo; Uemura, Hirokazu; Kuriyama, Nagato; Ohnaka, Keizo; Kubo, Michiaki; Hamajima, Nobuyuki; Tanaka, Hideo; Wakai, Kenji.

In: British Journal of Nutrition, Vol. 118, No. 6, 28.09.2017, p. 463-472.

Research output: Contribution to journalArticle

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T1 - Macronutrient intakes and serum oestrogen, and interaction with polymorphisms in CYP19A1 and HSD17B1 genes

T2 - A cross-sectional study in postmenopausal Japanese women

AU - Takagi, Sahoko

AU - Naito, Mariko

AU - Kawai, Sayo

AU - Okada, Rieko

AU - Nagata, Chisato

AU - Hosono, Satoyo

AU - Nishida, Yuichiro

AU - Takashima, Naoyuki

AU - Suzuki, Sadao

AU - Shimoshikiryo, Ippei

AU - Mikami, Haruo

AU - Uemura, Hirokazu

AU - Kuriyama, Nagato

AU - Ohnaka, Keizo

AU - Kubo, Michiaki

AU - Hamajima, Nobuyuki

AU - Tanaka, Hideo

AU - Wakai, Kenji

PY - 2017/9/28

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N2 - Although higher circulating levels of oestrogen are related to postmenopausal breast cancer risk, limited information is available regarding effects of diet on endogenous oestrogen. Thus, we examined associations between macronutrient intakes and serum oestrogen with consideration of polymorphisms in oestrogen-metabolising genes. In this cross-sectional study, 784 naturally menopaused Japanese women aged 47-69 years were selected from participants of the Japan Multi-Institutional Collaborative Cohort Study. We documented dietary intakes, measured serum concentrations of oestrone (E1) and oestradiol (E2) and genotyped polymorphisms in oestrogen-metabolising CYP19A1 (rs4441215 and rs936306) and HSD17B1 (rs605059) genes. Trends and interactions were examined using linear regression models. In addition, we calculated the ratios of the oestrogen concentrations of the second to the highest quartiles (Q2-Q4) of dietary intake to those of the lowest quartiles (Q1). After adjustment for potential confounders, E2 was significantly associated with intake of carbohydrate and noodles; ratios of Q4 v. Q1 were 1·15 (95 % CI 1·04, 1·28) and 1·15 (95 % CI 1·04, 1·26), respectively. In contrast, E2 levels were inversely associated with intake of total energy, SFA and n-3 highly unsaturated fatty acids (n-3 HUFA); ratios of Q4 v. Q1 were 0·90 (95 % CI 0·82, 0·99), 0·89 (95 % CI 0·81, 0·98) and 0·91 (95 % CI 0·83, 1·00), respectively. In stratified analysis by polymorphisms, the rs605059 genotype of HSD17B1 significantly modified associations of E2 with intake of n-3 HUFA and fish; the associations were limited to those with the CC genotype. Macronutrient intakes were associated with serum E2 level, and these associations may be modified by HSD17B1 polymorphism in postmenopausal women.

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