TY - JOUR
T1 - Macrophage inflammatory protein-3 alpha (MIP-3a) Is a novel serum prognostic marker in patients with colorectal cancer
AU - Iwata, Takashi
AU - Tanaka, Koji
AU - Inoue, Yasuhiro
AU - Toiyama, Yuji
AU - Hiro, Junichiro
AU - Fujikawa, Hiroyuki
AU - Okugawa, Yoshinaga
AU - Uchida, Keiichi
AU - Mohri, Yasuhiko
AU - Kusunoki, Masato
PY - 2013/2
Y1 - 2013/2
N2 - Background and Objectives: A significant prognostic difference exists among metastatic colorectal cancer (CRC) patients despite of any treatments. We identify the specific cytokines related to prognosis of metastatic CRC and assess their prognostic significance. Methods: Stage IV CRC patients were divided into two groups according to their prognosis. Difference in serum cytokine level between these groups was determined by the cytokine array. Among the specific cytokines, macrophage inflammatory protein-3 alpha (MIP-3a) was measured using an enzyme-linked immunosorbent assay (ELISA) in the sera of 242 CRC patients. Results Several cytokines related to prognostic difference in stage IV CRC were identified. The median MIP-3a level (28.2 pg/ml) was used as a cut-off value. Increased MIP-3a was significantly associated with synchronous liver metastases and age. In univariate analysis, high MIP-3a was correlated with poor prognosis (P < 0.001). Multivariate analysis showed that high MIP-3a was an independent prognostic factor in all CRC patients (P < 0.001). In subgroup analysis, high MIP-3a was significantly associated with poor survival in patients with stage II, II/III, and IV CRC, respectively. Conclusions: Serum MIP-3a is not only an independent prognostic factor, but also an independent predictive factor for liver metastasis, which may guide the decision making of metastatic CRC patients.
AB - Background and Objectives: A significant prognostic difference exists among metastatic colorectal cancer (CRC) patients despite of any treatments. We identify the specific cytokines related to prognosis of metastatic CRC and assess their prognostic significance. Methods: Stage IV CRC patients were divided into two groups according to their prognosis. Difference in serum cytokine level between these groups was determined by the cytokine array. Among the specific cytokines, macrophage inflammatory protein-3 alpha (MIP-3a) was measured using an enzyme-linked immunosorbent assay (ELISA) in the sera of 242 CRC patients. Results Several cytokines related to prognostic difference in stage IV CRC were identified. The median MIP-3a level (28.2 pg/ml) was used as a cut-off value. Increased MIP-3a was significantly associated with synchronous liver metastases and age. In univariate analysis, high MIP-3a was correlated with poor prognosis (P < 0.001). Multivariate analysis showed that high MIP-3a was an independent prognostic factor in all CRC patients (P < 0.001). In subgroup analysis, high MIP-3a was significantly associated with poor survival in patients with stage II, II/III, and IV CRC, respectively. Conclusions: Serum MIP-3a is not only an independent prognostic factor, but also an independent predictive factor for liver metastasis, which may guide the decision making of metastatic CRC patients.
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U2 - 10.1002/jso.23247
DO - 10.1002/jso.23247
M3 - Review article
C2 - 22926691
AN - SCOPUS:84872261751
SN - 0022-4790
VL - 107
SP - 160
EP - 166
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
IS - 2
ER -