TY - JOUR
T1 - Magnifying NBI Patterns of Gastric Mucosa After Helicobacter pylori Eradication and Its Potential Link to the Gastric Cancer Risk
AU - Tahara, Tomomitsu
AU - Tahara, Sayumi
AU - Tuskamoto, Tetsuya
AU - Horiguchi, Noriyuki
AU - Yoshida, Dai
AU - Kawamura, Tomohiko
AU - Okubo, Masaaki
AU - Nagasaka, Mitsuo
AU - Nakagawa, Yoshihito
AU - Urano, Makoto
AU - Kuroda, Makoto
AU - Shibata, Tomoyuki
AU - Ohmiya, Naoki
N1 - Publisher Copyright:
© 2017, Springer Science+Business Media, LLC.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Background: Gastric cancer develops after successful H. pylori eradication in patients with severe atrophic gastritis. We classified atrophic and non-atrophic mucosa of gastric body using magnifying NBI endoscopy in patients after successful H. pylori eradication. Materials and Methods: One hundred and twenty-five patients after successful H. pylori eradication (median period after eradication: 36 months) were enrolled. Magnifying NBI patterns in the uninvolved gastric body were divided into the following: restored-small, round pits, accompanied with honeycomb-like subepithelial capillary networks; atrophic-well-demarcated oval or tubulovillous pits with clearly visible coiled or wavy vessels. The subjects were also classified into the three types: Grade 0—restored pattern is shown in all or almost the entire area of gastric body; Grade 1—mixture of restored and atrophic pattern, there is a considerable portion of the atrophic area in the lesser curvature; Grade 2—atrophic pattern is shown in all or almost the entire area of the gastric body. Results: Sensitivity and specificity for atrophic type for detection of histological intestinal metaplasia were 95.9 and 98.3%, respectively. No association was observed between the prevalence of Grades 0, 1 and 2 and duration after eradication, while grades 1 and 2 were significantly frequent in gastric cancer patients diagnosed both before (27/35: 77%) and after (23/31: 74%) eradication, compared to the cancer-free subjects (15/59: 25%) (P < 0.001). The grades 1 and 2 were also common in patients who underwent H. pylori eradication for gastric ulcer. Conclusions: Magnifying the NBI pattern well correlates with pathological status of gastric mucosa after H. pylori eradication and may predict gastric cancer occurrence.
AB - Background: Gastric cancer develops after successful H. pylori eradication in patients with severe atrophic gastritis. We classified atrophic and non-atrophic mucosa of gastric body using magnifying NBI endoscopy in patients after successful H. pylori eradication. Materials and Methods: One hundred and twenty-five patients after successful H. pylori eradication (median period after eradication: 36 months) were enrolled. Magnifying NBI patterns in the uninvolved gastric body were divided into the following: restored-small, round pits, accompanied with honeycomb-like subepithelial capillary networks; atrophic-well-demarcated oval or tubulovillous pits with clearly visible coiled or wavy vessels. The subjects were also classified into the three types: Grade 0—restored pattern is shown in all or almost the entire area of gastric body; Grade 1—mixture of restored and atrophic pattern, there is a considerable portion of the atrophic area in the lesser curvature; Grade 2—atrophic pattern is shown in all or almost the entire area of the gastric body. Results: Sensitivity and specificity for atrophic type for detection of histological intestinal metaplasia were 95.9 and 98.3%, respectively. No association was observed between the prevalence of Grades 0, 1 and 2 and duration after eradication, while grades 1 and 2 were significantly frequent in gastric cancer patients diagnosed both before (27/35: 77%) and after (23/31: 74%) eradication, compared to the cancer-free subjects (15/59: 25%) (P < 0.001). The grades 1 and 2 were also common in patients who underwent H. pylori eradication for gastric ulcer. Conclusions: Magnifying the NBI pattern well correlates with pathological status of gastric mucosa after H. pylori eradication and may predict gastric cancer occurrence.
KW - Gastric atrophy
KW - Gastric cancer
KW - H. pylori eradication
KW - Magnifying NBI endoscopy
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U2 - 10.1007/s10620-017-4676-x
DO - 10.1007/s10620-017-4676-x
M3 - Article
C2 - 28702753
AN - SCOPUS:85023182691
SN - 0163-2116
VL - 62
SP - 2421
EP - 2427
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 9
ER -