Major and minor histocompatibility antigens in allogeneic hematopoietic stem cell transplantation

Yoshiki Akatsuka, Yasuo Morishima

Research output: Contribution to journalReview article


The critical role of molecular biology-based HLA allele matching for transplant-related immunologic events has been demonstrated. Potential applications of hematopoietic cell-specific minor histocompatibility antigens to immunotherapy by selectively augmenting the graft-versus-leukemia/lymphoma effect have been studied. These extensive efforts will increase the number of patients who can benefit from allogeneic HSCT over HLA disparity, or from active and selective immunotherapy, or both. 71.

Original languageEnglish
Pages (from-to)64-71
Number of pages8
JournalCurrent Opinion in Organ Transplantation
Issue number1
Publication statusPublished - 01-01-2004


All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Transplantation

Cite this