MALAT1 long non-coding RNA in cancer

Rei Yoshimoto, Akira Maeda, Minoru Yoshida, Shinichi Nakagawa

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

A recent massive parallel sequencing analysis has shown the fact that more than 80% of the human genome is transcribed into RNA. Among many kinds of the non-protein coding RNAs, we focus on the metastasis associated lung adenocarcinoma transcript 1 (MALAT1) that is a long non-coding RNA upregulated in metastatic carcinoma cells. Two molecular functions of MALAT1 have been proposed, one is the control of alternative splicing and the other is the transcriptional regulation. In this review, we document the molecular characteristics and functions of MALAT1 and shed light on the implication in the molecular pathology of various cancers. This article is part of a Special Issue entitled: Clues to long noncoding RNA taxonomy1, edited by Dr. Tetsuro Hirose and Dr. Shinichi Nakagawa.

Original languageEnglish
Pages (from-to)192-199
Number of pages8
JournalBiochimica et Biophysica Acta - Gene Regulatory Mechanisms
Volume1859
Issue number1
DOIs
Publication statusPublished - 01-01-2016

Fingerprint

Long Noncoding RNA
Neoplasm Metastasis
Untranslated RNA
Alternative Splicing
Pathology
Neoplasms
Molecular Pathology
Genes
Cells
Human Genome
RNA
Carcinoma
Adenocarcinoma of lung

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Yoshimoto, Rei ; Maeda, Akira ; Yoshida, Minoru ; Nakagawa, Shinichi. / MALAT1 long non-coding RNA in cancer. In: Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 2016 ; Vol. 1859, No. 1. pp. 192-199.
@article{fc28bb6736df4d56b0f45f33b5c217e4,
title = "MALAT1 long non-coding RNA in cancer",
abstract = "A recent massive parallel sequencing analysis has shown the fact that more than 80{\%} of the human genome is transcribed into RNA. Among many kinds of the non-protein coding RNAs, we focus on the metastasis associated lung adenocarcinoma transcript 1 (MALAT1) that is a long non-coding RNA upregulated in metastatic carcinoma cells. Two molecular functions of MALAT1 have been proposed, one is the control of alternative splicing and the other is the transcriptional regulation. In this review, we document the molecular characteristics and functions of MALAT1 and shed light on the implication in the molecular pathology of various cancers. This article is part of a Special Issue entitled: Clues to long noncoding RNA taxonomy1, edited by Dr. Tetsuro Hirose and Dr. Shinichi Nakagawa.",
author = "Rei Yoshimoto and Akira Maeda and Minoru Yoshida and Shinichi Nakagawa",
year = "2016",
month = "1",
day = "1",
doi = "10.1016/j.bbagrm.2015.09.012",
language = "English",
volume = "1859",
pages = "192--199",
journal = "Biochimica et Biophysica Acta - Gene Regulatory Mechanisms",
issn = "1874-9399",
publisher = "Elsevier",
number = "1",

}

MALAT1 long non-coding RNA in cancer. / Yoshimoto, Rei; Maeda, Akira; Yoshida, Minoru; Nakagawa, Shinichi.

In: Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, Vol. 1859, No. 1, 01.01.2016, p. 192-199.

Research output: Contribution to journalArticle

TY - JOUR

T1 - MALAT1 long non-coding RNA in cancer

AU - Yoshimoto, Rei

AU - Maeda, Akira

AU - Yoshida, Minoru

AU - Nakagawa, Shinichi

PY - 2016/1/1

Y1 - 2016/1/1

N2 - A recent massive parallel sequencing analysis has shown the fact that more than 80% of the human genome is transcribed into RNA. Among many kinds of the non-protein coding RNAs, we focus on the metastasis associated lung adenocarcinoma transcript 1 (MALAT1) that is a long non-coding RNA upregulated in metastatic carcinoma cells. Two molecular functions of MALAT1 have been proposed, one is the control of alternative splicing and the other is the transcriptional regulation. In this review, we document the molecular characteristics and functions of MALAT1 and shed light on the implication in the molecular pathology of various cancers. This article is part of a Special Issue entitled: Clues to long noncoding RNA taxonomy1, edited by Dr. Tetsuro Hirose and Dr. Shinichi Nakagawa.

AB - A recent massive parallel sequencing analysis has shown the fact that more than 80% of the human genome is transcribed into RNA. Among many kinds of the non-protein coding RNAs, we focus on the metastasis associated lung adenocarcinoma transcript 1 (MALAT1) that is a long non-coding RNA upregulated in metastatic carcinoma cells. Two molecular functions of MALAT1 have been proposed, one is the control of alternative splicing and the other is the transcriptional regulation. In this review, we document the molecular characteristics and functions of MALAT1 and shed light on the implication in the molecular pathology of various cancers. This article is part of a Special Issue entitled: Clues to long noncoding RNA taxonomy1, edited by Dr. Tetsuro Hirose and Dr. Shinichi Nakagawa.

UR - http://www.scopus.com/inward/record.url?scp=84953350072&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84953350072&partnerID=8YFLogxK

U2 - 10.1016/j.bbagrm.2015.09.012

DO - 10.1016/j.bbagrm.2015.09.012

M3 - Article

C2 - 26434412

AN - SCOPUS:84953350072

VL - 1859

SP - 192

EP - 199

JO - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

JF - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

SN - 1874-9399

IS - 1

ER -