Male siblings with dyserythropoiesis, microcephaly and intrauterine growth retardation

K. Okajima, Tetsuya Ito, A. Wakita, Y. Suzuki, M. Nagahama, M. Shamoto, M. Eguchi, Y. Wada

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Male siblings with intrauterine growth retardation, hydrops, mild liver dysfunction, chronic diarrhoea, failure to thrive and microcephaly are reported. In both patients, the intrauterine growth retardation was detected in the second trimester of pregnancy. Relatively severe early onset neonatal jaundice, microcytosis, anisocytosis and abnormal iron metabolism were also seen. Bone marrow examination in the second sibling showed marked ringed sideroblasts and multilobulated erythroblasts in late developmental stages. The brain was very small with enlarged cerebrospinal fluid space, a reduced number of gyri and a thin cortex. The clinical and laboratory findings in these patients appear to be unique.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalClinical Dysmorphology
Volume11
Issue number2
DOIs
Publication statusPublished - 01-01-2002
Externally publishedYes

Fingerprint

Microcephaly
Fetal Growth Retardation
Siblings
Neonatal Jaundice
Bone Marrow Examination
Failure to Thrive
Erythroblasts
Second Pregnancy Trimester
Cerebrospinal Fluid
Liver Diseases
Diarrhea
Edema
Iron
Brain

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Anatomy
  • Pathology and Forensic Medicine
  • Genetics(clinical)

Cite this

Okajima, K. ; Ito, Tetsuya ; Wakita, A. ; Suzuki, Y. ; Nagahama, M. ; Shamoto, M. ; Eguchi, M. ; Wada, Y. / Male siblings with dyserythropoiesis, microcephaly and intrauterine growth retardation. In: Clinical Dysmorphology. 2002 ; Vol. 11, No. 2. pp. 107-111.
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Okajima, K, Ito, T, Wakita, A, Suzuki, Y, Nagahama, M, Shamoto, M, Eguchi, M & Wada, Y 2002, 'Male siblings with dyserythropoiesis, microcephaly and intrauterine growth retardation', Clinical Dysmorphology, vol. 11, no. 2, pp. 107-111. https://doi.org/10.1097/00019605-200204000-00006

Male siblings with dyserythropoiesis, microcephaly and intrauterine growth retardation. / Okajima, K.; Ito, Tetsuya; Wakita, A.; Suzuki, Y.; Nagahama, M.; Shamoto, M.; Eguchi, M.; Wada, Y.

In: Clinical Dysmorphology, Vol. 11, No. 2, 01.01.2002, p. 107-111.

Research output: Contribution to journalArticle

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