Abstract
Rhabdoid tumor (RT) of the central nervous system is an uncommon and aggressive neoplasm that usually affects pediatric patients. Currently, these tumors are classified as malignant RT or atypical teratoid/RT. Another entity of intraparenchymal brain tumor with a rhabdoid component is the extremely rare rhabdoid glioblastoma. A 23-year-old woman presented with a malignant RT in the right thalamus. The tumor was adjacent to the right lateral ventricle and was partially resected. Histological examination revealed prominent proliferation of rhabdoid cells, which is consistent with a diagnosis of malignant RT; the typical features of glioblastoma were not observed. The tumor cells stained positively for integrase interactor-1 and glial fibrillary acidic protein. Therefore, the tumor may have originated from glial components. Genetic analysis using comparative genomic hybridization showed a deoxyribonucleic acid copy-number gain on chromosome 7 but not on chromosome 22. The tumor did not respond to chemotherapy or radiotherapy, and the patient survived for only 4 months after surgery. The present case of malignant RTs shows certain similarities with those of rhabdoid glioblastoma. Further accumulation and analysis of data, including data from genetic analyses, may lead to the identification of a new type of malignant RT.
| Original language | English |
|---|---|
| Pages (from-to) | 449-454 |
| Number of pages | 6 |
| Journal | Neurologia medico-chirurgica |
| Volume | 51 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 06-07-2011 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Clinical Neurology
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Malignant brain tumor with rhabdoid features in an adult : Case report. / Mutou, Jun; Hirose, Yuichi; Ikeda, Eiji; Yoshida, Kazunari; Nakazato, Yoichi; Kawase, Takeshi.
In: Neurologia medico-chirurgica, Vol. 51, No. 6, 06.07.2011, p. 449-454.Research output: Contribution to journal › Article
TY - JOUR
T1 - Malignant brain tumor with rhabdoid features in an adult
T2 - Case report
AU - Mutou, Jun
AU - Hirose, Yuichi
AU - Ikeda, Eiji
AU - Yoshida, Kazunari
AU - Nakazato, Yoichi
AU - Kawase, Takeshi
PY - 2011/7/6
Y1 - 2011/7/6
N2 - Rhabdoid tumor (RT) of the central nervous system is an uncommon and aggressive neoplasm that usually affects pediatric patients. Currently, these tumors are classified as malignant RT or atypical teratoid/RT. Another entity of intraparenchymal brain tumor with a rhabdoid component is the extremely rare rhabdoid glioblastoma. A 23-year-old woman presented with a malignant RT in the right thalamus. The tumor was adjacent to the right lateral ventricle and was partially resected. Histological examination revealed prominent proliferation of rhabdoid cells, which is consistent with a diagnosis of malignant RT; the typical features of glioblastoma were not observed. The tumor cells stained positively for integrase interactor-1 and glial fibrillary acidic protein. Therefore, the tumor may have originated from glial components. Genetic analysis using comparative genomic hybridization showed a deoxyribonucleic acid copy-number gain on chromosome 7 but not on chromosome 22. The tumor did not respond to chemotherapy or radiotherapy, and the patient survived for only 4 months after surgery. The present case of malignant RTs shows certain similarities with those of rhabdoid glioblastoma. Further accumulation and analysis of data, including data from genetic analyses, may lead to the identification of a new type of malignant RT.
AB - Rhabdoid tumor (RT) of the central nervous system is an uncommon and aggressive neoplasm that usually affects pediatric patients. Currently, these tumors are classified as malignant RT or atypical teratoid/RT. Another entity of intraparenchymal brain tumor with a rhabdoid component is the extremely rare rhabdoid glioblastoma. A 23-year-old woman presented with a malignant RT in the right thalamus. The tumor was adjacent to the right lateral ventricle and was partially resected. Histological examination revealed prominent proliferation of rhabdoid cells, which is consistent with a diagnosis of malignant RT; the typical features of glioblastoma were not observed. The tumor cells stained positively for integrase interactor-1 and glial fibrillary acidic protein. Therefore, the tumor may have originated from glial components. Genetic analysis using comparative genomic hybridization showed a deoxyribonucleic acid copy-number gain on chromosome 7 but not on chromosome 22. The tumor did not respond to chemotherapy or radiotherapy, and the patient survived for only 4 months after surgery. The present case of malignant RTs shows certain similarities with those of rhabdoid glioblastoma. Further accumulation and analysis of data, including data from genetic analyses, may lead to the identification of a new type of malignant RT.
UR - http://www.scopus.com/inward/record.url?scp=79959851145&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79959851145&partnerID=8YFLogxK
U2 - 10.2176/nmc.51.449
DO - 10.2176/nmc.51.449
M3 - Article
C2 - 21701112
AN - SCOPUS:79959851145
VL - 51
SP - 449
EP - 454
JO - Neurologia Medico-Chirurgica
JF - Neurologia Medico-Chirurgica
SN - 0387-2572
IS - 6
ER -