Malignant fibrous histiocytoma of the cecum: Report of a case and review of the literature

Nobuyoshi Hiraoka, Makio Mukai, Masako Suzuki, Kotaro Maeda, Ken Ichiro Nakajima, Mitsumasa Hashimoto, Youichiro Hosoda, Jun Ichi Hata

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Malignant fibrous histiocytoma (MFH) of the gastrointestinal tract is extremely rare. Here we report e case of MFH of the cecum and review other cases of large bowel MFH in the literature. A 64-year-old man had a large tumor mass in the cecum associated with multiple small peritoneal implants. Histologically, most of the lesion showed inflammatory pseudotumor-like appearance; that is, a mixed proliferation of fibroblasts and myofibroblasts loosely arranged in sweeping fascicles or whorled structures and an admixture of chronic inflammatory cell infiltrate. The myofibroblastic nature of the spindle-shaped cells was confirmed by their immunohistochemical and ultrastructural findings. In addition, there was atypical histiocytic cells infiltrate in some areas and marked lymphatic involvement and lymph node metastasis by such histiocytic cells. These features were interpreted as MFH, although it had to be distinguished from inflammatory fibrosarcoma and lelomyosarcoma. The differential diagnosis is discussed here.

Original languageEnglish
Pages (from-to)718-724
Number of pages7
JournalPathology International
Volume47
Issue number10
DOIs
Publication statusPublished - 1997

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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