TY - JOUR
T1 - Mammal-specific H2A variant, H2ABbd, is involved in apoptotic induction via activation of NF-ƘB signaling pathway
AU - Goshima, Takahiro
AU - Shimada, Midori
AU - Sharif, Jafar
AU - Matsuo, Hiromi
AU - Misaki, Toshinori
AU - Johmura, Yoshikazu
AU - Murata, Kazuhiro
AU - Koseki, Haruhiko
AU - Nakanishi, Makoto
PY - 2014/4/25
Y1 - 2014/4/25
N2 - Background: H2ABbd is an H2A variant possessing a highly divergent structure. However, the in vivo function of H2ABbdis not understood.Results: Expression of H2ABbd caused DNA damage, induced apoptotis, and finally led to cell death.Conclusion: H2ABbd caused apoptosis in caspase 3- and NF-ƘB-dependent manners.Significance: This work describes a novel role for human H2ABbd in gene regulation and cell death.
AB - Background: H2ABbd is an H2A variant possessing a highly divergent structure. However, the in vivo function of H2ABbdis not understood.Results: Expression of H2ABbd caused DNA damage, induced apoptotis, and finally led to cell death.Conclusion: H2ABbd caused apoptosis in caspase 3- and NF-ƘB-dependent manners.Significance: This work describes a novel role for human H2ABbd in gene regulation and cell death.
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U2 - 10.1074/jbc.M113.541664
DO - 10.1074/jbc.M113.541664
M3 - Article
C2 - 24584930
AN - SCOPUS:84899462295
SN - 0021-9258
VL - 289
SP - 11656
EP - 11666
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 17
ER -