Mammal-specific H2A variant, H2ABbd, is involved in apoptotic induction via activation of NF-ƘB signaling pathway

Takahiro Goshima, Midori Shimada, Jafar Sharif, Hiromi Matsuo, Toshinori Misaki, Yoshikazu Johmura, Kazuhiro Murata, Haruhiko Koseki, Makoto Nakanishi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: H2ABbd is an H2A variant possessing a highly divergent structure. However, the in vivo function of H2ABbdis not understood.Results: Expression of H2ABbd caused DNA damage, induced apoptotis, and finally led to cell death.Conclusion: H2ABbd caused apoptosis in caspase 3- and NF-ƘB-dependent manners.Significance: This work describes a novel role for human H2ABbd in gene regulation and cell death.

Original languageEnglish
Pages (from-to)11656-11666
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number17
DOIs
Publication statusPublished - 25-04-2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Goshima, T., Shimada, M., Sharif, J., Matsuo, H., Misaki, T., Johmura, Y., Murata, K., Koseki, H., & Nakanishi, M. (2014). Mammal-specific H2A variant, H2ABbd, is involved in apoptotic induction via activation of NF-ƘB signaling pathway. Journal of Biological Chemistry, 289(17), 11656-11666. https://doi.org/10.1074/jbc.M113.541664