Mammal-specific H2A variant, H2ABbd, is involved in apoptotic induction via activation of NF-ƘB signaling pathway

Takahiro Goshima; Midori Shimada; Jafar Sharif; Hiromi Matsuo; Toshinori Misaki; Yoshikazu Johmura; Kazuhiro Murata; Haruhiko Koseki; Makoto Nakanishi

doi:10.1074/jbc.M113.541664

Mammal-specific H2A variant, H2ABbd, is involved in apoptotic induction via activation of NF-ƘB signaling pathway

Takahiro Goshima
, Midori Shimada
, Jafar Sharif
, Hiromi Matsuo
, Toshinori Misaki
, Yoshikazu Johmura
, Kazuhiro Murata
, Haruhiko Koseki
, Makoto Nakanishi

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Background: H2ABbd is an H2A variant possessing a highly divergent structure. However, the in vivo function of H2ABbdis not understood.Results: Expression of H2ABbd caused DNA damage, induced apoptotis, and finally led to cell death.Conclusion: H2ABbd caused apoptosis in caspase 3- and NF-ƘB-dependent manners.Significance: This work describes a novel role for human H2ABbd in gene regulation and cell death.

Original language	English
Pages (from-to)	11656-11666
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	289
Issue number	17
DOIs	https://doi.org/10.1074/jbc.M113.541664
Publication status	Published - 25-04-2014
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.541664

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title = "Mammal-specific H2A variant, H2ABbd, is involved in apoptotic induction via activation of NF-ƘB signaling pathway",

abstract = "Background: H2ABbd is an H2A variant possessing a highly divergent structure. However, the in vivo function of H2ABbdis not understood.Results: Expression of H2ABbd caused DNA damage, induced apoptotis, and finally led to cell death.Conclusion: H2ABbd caused apoptosis in caspase 3- and NF-ƘB-dependent manners.Significance: This work describes a novel role for human H2ABbd in gene regulation and cell death.",

author = "Takahiro Goshima and Midori Shimada and Jafar Sharif and Hiromi Matsuo and Toshinori Misaki and Yoshikazu Johmura and Kazuhiro Murata and Haruhiko Koseki and Makoto Nakanishi",

year = "2014",

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doi = "10.1074/jbc.M113.541664",

language = "English",

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journal = "Journal of Biological Chemistry",

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T1 - Mammal-specific H2A variant, H2ABbd, is involved in apoptotic induction via activation of NF-ƘB signaling pathway

AU - Goshima, Takahiro

AU - Shimada, Midori

AU - Sharif, Jafar

AU - Matsuo, Hiromi

AU - Misaki, Toshinori

AU - Johmura, Yoshikazu

AU - Murata, Kazuhiro

AU - Koseki, Haruhiko

AU - Nakanishi, Makoto

PY - 2014/4/25

Y1 - 2014/4/25

N2 - Background: H2ABbd is an H2A variant possessing a highly divergent structure. However, the in vivo function of H2ABbdis not understood.Results: Expression of H2ABbd caused DNA damage, induced apoptotis, and finally led to cell death.Conclusion: H2ABbd caused apoptosis in caspase 3- and NF-ƘB-dependent manners.Significance: This work describes a novel role for human H2ABbd in gene regulation and cell death.

AB - Background: H2ABbd is an H2A variant possessing a highly divergent structure. However, the in vivo function of H2ABbdis not understood.Results: Expression of H2ABbd caused DNA damage, induced apoptotis, and finally led to cell death.Conclusion: H2ABbd caused apoptosis in caspase 3- and NF-ƘB-dependent manners.Significance: This work describes a novel role for human H2ABbd in gene regulation and cell death.

UR - https://www.scopus.com/pages/publications/84899462295

UR - https://www.scopus.com/pages/publications/84899462295#tab=citedBy

U2 - 10.1074/jbc.M113.541664

DO - 10.1074/jbc.M113.541664

M3 - Article

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AN - SCOPUS:84899462295

SN - 0021-9258

VL - 289

SP - 11656

EP - 11666

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 17

ER -

Mammal-specific H2A variant, H2ABbd, is involved in apoptotic induction via activation of NF-ƘB signaling pathway

Abstract

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