TY - JOUR
T1 - Management of pilomyxoid astrocytomas
T2 - Our experience
AU - Tsugu, Hitoshi
AU - Oshiro, Shinya
AU - Yanai, Fumio
AU - Komatsu, Fuminari
AU - Abe, Hiroshi
AU - Fukushima, Takeo
AU - Nomura, Yuko
AU - Matsumoto, Shinji
AU - Nabeshima, Kazuki
AU - Takano, Koichi
AU - Utsunomiya, Hidetsuna
N1 - Funding Information:
We thank G. Haberhauer for help with computer applications and A. Ochs for help with sequence analysis. This work was supported by Deutsche Forschungsgemeinschaft and Bundesministerium für Bildung und Forschung.
PY - 2009/3
Y1 - 2009/3
N2 - Background: Pilomyxoid astrocytoma (PMA) shows a higher rate of recurrence and cerebrospinal fluid (CSF) dissemination than does pilocytic astrocytoma (PA). In this article, we discuss the treatment of PMA. Materials and Methods: Between 1992 and 2007, the authors treated 5 patients. Two of these were male, three female. Their ages ranged from 3 months to 11 years. Results: Three patients showed CSF dissemination on the initial radiographic examination. All patients received chemotherapy; the most commonly used combination drugs were cisplatin (CDDP)/carboplatin (CBDCA) and etoposide. When these drugs were unsuccessful, they were changed or other drugs added to the combination. After chemotherapy, four patients showed remarkable tumor regression. Nevertheless, one patient died 22 months after initial diagnosis, due to tumor progression. Conclusion: While our series was limited to a small number of patients, we have a positive impression of the value of chemotherapy. Even if initial chemotherapy is ineffective, we recommend continued CDDP/CBDCA-based chemotherapy with new drug combinations.
AB - Background: Pilomyxoid astrocytoma (PMA) shows a higher rate of recurrence and cerebrospinal fluid (CSF) dissemination than does pilocytic astrocytoma (PA). In this article, we discuss the treatment of PMA. Materials and Methods: Between 1992 and 2007, the authors treated 5 patients. Two of these were male, three female. Their ages ranged from 3 months to 11 years. Results: Three patients showed CSF dissemination on the initial radiographic examination. All patients received chemotherapy; the most commonly used combination drugs were cisplatin (CDDP)/carboplatin (CBDCA) and etoposide. When these drugs were unsuccessful, they were changed or other drugs added to the combination. After chemotherapy, four patients showed remarkable tumor regression. Nevertheless, one patient died 22 months after initial diagnosis, due to tumor progression. Conclusion: While our series was limited to a small number of patients, we have a positive impression of the value of chemotherapy. Even if initial chemotherapy is ineffective, we recommend continued CDDP/CBDCA-based chemotherapy with new drug combinations.
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M3 - Article
C2 - 19414328
AN - SCOPUS:64949106440
SN - 0250-7005
VL - 29
SP - 919
EP - 926
JO - Anticancer research
JF - Anticancer research
IS - 3
ER -
