Management of small-bowel polyps in Peutz-Jeghers syndrome by using enteroclysis, double-balloon enteroscopy, and videocapsule endoscopy

Naoki Ohmiya, Masanao Nakamura, Hiroyuki Takenaka, Kenji Morishima, Takeshi Yamamura, Makoto Ishihara, Ryoji Miyahara, Hiroki Kawashima, Akihiro Itoh, Yoshiki Hirooka, Osamu Watanabe, Takafumi Ando, Hidemi Goto

Research output: Contribution to journalArticle

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Abstract

Background Management of small-bowel polyps in Peutz-Jeghers syndrome (PJS) by using fluoroscopic enteroclysis (FE), double-balloon enteroscopy (DBE), and videocapsule enteroscopy (VCE) remains incompletely determined. Objective To evaluate the usefulness of FE, VCE, and DBE and compute the polyp growth rate. Design Single-center retrospective study. Setting Tertiary referral hospital. Patients Between June 2003 and January 2010, 18 consecutive patients with PJS were enrolled. Main Outcome Measurements Polyp detection rates among FE, VCE, and DBE, histology of resected polyps, and the polyp growth rate. Results Total enteroscopy rate was higher at VCE (89%) than at DBE (52%; 27% in patients with <2 previous laparotomies and 90% in patients with ≤1 [P = .001]). FE demonstrated fewer polyps than DBE, whereas VCE had detection rates similar to those of DBE. Of 387 DBE-resected and 22 surgically resected polyps, histologic analysis of 110 retrieved polyps showed adenoma or adenocarcinoma in 30.0% of polyps >20 mm and in only 1.3% of polyps ≤20 mm (P < .0001). Multiple linear regression analysis showed that the number of small-bowel polyps >10 mm (X1; P = .0366) and colorectal polyps >5 mm (X2; P = .002) were independent predictors of the growth rate of small-bowel polyps (Y), and a forward stepwise selection model was constructed: Y = 0.136 × X1 + 0.289 × X2 - 0.589 (R2 = 0.665). Limitations Small sample size. Conclusions DBE and VCE were useful for the management of small-bowel polyps in PJS. VCE may replace barium examinations for surveillance after polyp resection at intervals depending on the polyp growth rate.

Original languageEnglish
Pages (from-to)1209-1216
Number of pages8
JournalGastrointestinal Endoscopy
Volume72
Issue number6
DOIs
Publication statusPublished - 01-12-2010
Externally publishedYes

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Double-Balloon Enteroscopy
Peutz-Jeghers Syndrome
Polyps
Endoscopy
Growth
Barium
Tertiary Care Centers
Sample Size

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

Ohmiya, Naoki ; Nakamura, Masanao ; Takenaka, Hiroyuki ; Morishima, Kenji ; Yamamura, Takeshi ; Ishihara, Makoto ; Miyahara, Ryoji ; Kawashima, Hiroki ; Itoh, Akihiro ; Hirooka, Yoshiki ; Watanabe, Osamu ; Ando, Takafumi ; Goto, Hidemi. / Management of small-bowel polyps in Peutz-Jeghers syndrome by using enteroclysis, double-balloon enteroscopy, and videocapsule endoscopy. In: Gastrointestinal Endoscopy. 2010 ; Vol. 72, No. 6. pp. 1209-1216.
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abstract = "Background Management of small-bowel polyps in Peutz-Jeghers syndrome (PJS) by using fluoroscopic enteroclysis (FE), double-balloon enteroscopy (DBE), and videocapsule enteroscopy (VCE) remains incompletely determined. Objective To evaluate the usefulness of FE, VCE, and DBE and compute the polyp growth rate. Design Single-center retrospective study. Setting Tertiary referral hospital. Patients Between June 2003 and January 2010, 18 consecutive patients with PJS were enrolled. Main Outcome Measurements Polyp detection rates among FE, VCE, and DBE, histology of resected polyps, and the polyp growth rate. Results Total enteroscopy rate was higher at VCE (89{\%}) than at DBE (52{\%}; 27{\%} in patients with <2 previous laparotomies and 90{\%} in patients with ≤1 [P = .001]). FE demonstrated fewer polyps than DBE, whereas VCE had detection rates similar to those of DBE. Of 387 DBE-resected and 22 surgically resected polyps, histologic analysis of 110 retrieved polyps showed adenoma or adenocarcinoma in 30.0{\%} of polyps >20 mm and in only 1.3{\%} of polyps ≤20 mm (P < .0001). Multiple linear regression analysis showed that the number of small-bowel polyps >10 mm (X1; P = .0366) and colorectal polyps >5 mm (X2; P = .002) were independent predictors of the growth rate of small-bowel polyps (Y), and a forward stepwise selection model was constructed: Y = 0.136 × X1 + 0.289 × X2 - 0.589 (R2 = 0.665). Limitations Small sample size. Conclusions DBE and VCE were useful for the management of small-bowel polyps in PJS. VCE may replace barium examinations for surveillance after polyp resection at intervals depending on the polyp growth rate.",
author = "Naoki Ohmiya and Masanao Nakamura and Hiroyuki Takenaka and Kenji Morishima and Takeshi Yamamura and Makoto Ishihara and Ryoji Miyahara and Hiroki Kawashima and Akihiro Itoh and Yoshiki Hirooka and Osamu Watanabe and Takafumi Ando and Hidemi Goto",
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Ohmiya, N, Nakamura, M, Takenaka, H, Morishima, K, Yamamura, T, Ishihara, M, Miyahara, R, Kawashima, H, Itoh, A, Hirooka, Y, Watanabe, O, Ando, T & Goto, H 2010, 'Management of small-bowel polyps in Peutz-Jeghers syndrome by using enteroclysis, double-balloon enteroscopy, and videocapsule endoscopy', Gastrointestinal Endoscopy, vol. 72, no. 6, pp. 1209-1216. https://doi.org/10.1016/j.gie.2010.08.018

Management of small-bowel polyps in Peutz-Jeghers syndrome by using enteroclysis, double-balloon enteroscopy, and videocapsule endoscopy. / Ohmiya, Naoki; Nakamura, Masanao; Takenaka, Hiroyuki; Morishima, Kenji; Yamamura, Takeshi; Ishihara, Makoto; Miyahara, Ryoji; Kawashima, Hiroki; Itoh, Akihiro; Hirooka, Yoshiki; Watanabe, Osamu; Ando, Takafumi; Goto, Hidemi.

In: Gastrointestinal Endoscopy, Vol. 72, No. 6, 01.12.2010, p. 1209-1216.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Management of small-bowel polyps in Peutz-Jeghers syndrome by using enteroclysis, double-balloon enteroscopy, and videocapsule endoscopy

AU - Ohmiya, Naoki

AU - Nakamura, Masanao

AU - Takenaka, Hiroyuki

AU - Morishima, Kenji

AU - Yamamura, Takeshi

AU - Ishihara, Makoto

AU - Miyahara, Ryoji

AU - Kawashima, Hiroki

AU - Itoh, Akihiro

AU - Hirooka, Yoshiki

AU - Watanabe, Osamu

AU - Ando, Takafumi

AU - Goto, Hidemi

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Background Management of small-bowel polyps in Peutz-Jeghers syndrome (PJS) by using fluoroscopic enteroclysis (FE), double-balloon enteroscopy (DBE), and videocapsule enteroscopy (VCE) remains incompletely determined. Objective To evaluate the usefulness of FE, VCE, and DBE and compute the polyp growth rate. Design Single-center retrospective study. Setting Tertiary referral hospital. Patients Between June 2003 and January 2010, 18 consecutive patients with PJS were enrolled. Main Outcome Measurements Polyp detection rates among FE, VCE, and DBE, histology of resected polyps, and the polyp growth rate. Results Total enteroscopy rate was higher at VCE (89%) than at DBE (52%; 27% in patients with <2 previous laparotomies and 90% in patients with ≤1 [P = .001]). FE demonstrated fewer polyps than DBE, whereas VCE had detection rates similar to those of DBE. Of 387 DBE-resected and 22 surgically resected polyps, histologic analysis of 110 retrieved polyps showed adenoma or adenocarcinoma in 30.0% of polyps >20 mm and in only 1.3% of polyps ≤20 mm (P < .0001). Multiple linear regression analysis showed that the number of small-bowel polyps >10 mm (X1; P = .0366) and colorectal polyps >5 mm (X2; P = .002) were independent predictors of the growth rate of small-bowel polyps (Y), and a forward stepwise selection model was constructed: Y = 0.136 × X1 + 0.289 × X2 - 0.589 (R2 = 0.665). Limitations Small sample size. Conclusions DBE and VCE were useful for the management of small-bowel polyps in PJS. VCE may replace barium examinations for surveillance after polyp resection at intervals depending on the polyp growth rate.

AB - Background Management of small-bowel polyps in Peutz-Jeghers syndrome (PJS) by using fluoroscopic enteroclysis (FE), double-balloon enteroscopy (DBE), and videocapsule enteroscopy (VCE) remains incompletely determined. Objective To evaluate the usefulness of FE, VCE, and DBE and compute the polyp growth rate. Design Single-center retrospective study. Setting Tertiary referral hospital. Patients Between June 2003 and January 2010, 18 consecutive patients with PJS were enrolled. Main Outcome Measurements Polyp detection rates among FE, VCE, and DBE, histology of resected polyps, and the polyp growth rate. Results Total enteroscopy rate was higher at VCE (89%) than at DBE (52%; 27% in patients with <2 previous laparotomies and 90% in patients with ≤1 [P = .001]). FE demonstrated fewer polyps than DBE, whereas VCE had detection rates similar to those of DBE. Of 387 DBE-resected and 22 surgically resected polyps, histologic analysis of 110 retrieved polyps showed adenoma or adenocarcinoma in 30.0% of polyps >20 mm and in only 1.3% of polyps ≤20 mm (P < .0001). Multiple linear regression analysis showed that the number of small-bowel polyps >10 mm (X1; P = .0366) and colorectal polyps >5 mm (X2; P = .002) were independent predictors of the growth rate of small-bowel polyps (Y), and a forward stepwise selection model was constructed: Y = 0.136 × X1 + 0.289 × X2 - 0.589 (R2 = 0.665). Limitations Small sample size. Conclusions DBE and VCE were useful for the management of small-bowel polyps in PJS. VCE may replace barium examinations for surveillance after polyp resection at intervals depending on the polyp growth rate.

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