Mannan-binding lectin (MBL) polymorphism and gastric cancer risk in Japanese population

Fang Yu Wang, Tomomitsu Tahara, Tomiyasu Arisawa, Tomoyuki Shibata, Hiromi Yamashita, Masakatsu Nakamura, Daisuke Yoshioka, Masaaki Okubo, Naoko Maruyama, Toshiaki Kamano, Yoshio Kamiya, Masahiko Nakamura, Hiroshi Fujita, Mitsuo Nagasaka, Masami Iwata, Kazuya Takahama, Makoto Watanabe, Hiroshi Nakano, Ichiro Hirata

Research output: Contribution to journalArticle

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Abstract

Background: Mannan-binding lectin (MBL) is believed to be an important constituent of the innate immune system. It has been reported that the codon 54 G/A polymorphism of exon-1 affects the MBL2 gene and alters its activity. Aims: We investigated the association between polymorphism of the MBL2 gene and gastric cancer risk as well as Helicobacter pylori infection in a Japanese population. Methods: The study cohort comprised 388 gastric cancer patients and 144 healthy volunteers. Polymorphism at codon 54 of exon 1 of the MBL2 gene was investigated by PCR-based restriction fragment length polymorphism analysis. Results: There was no significant difference in the distribution of the MBL2 genotype among the gastric cancer patients and healthy controls. However, the carrier of the A allele was more prevalent among patients with a more advanced stage gastric cancer [odds ratio (OR) 1.68, 95% confidence interval (CI) 1.05-2.67; P = 0.03] and also had an increased risk of gastric cancer among patients 65 years of age or younger (OR = 1.6, 95%CI = 1.01-2.52, <0.05). Conclusion: The codon 54 polymorphism of the MBL2 gene is associated with more advanced phenotypes of gastric cancer and the risk of gastric cancer in Japanese patients 65 years of age or younger.

Original languageEnglish
Pages (from-to)2904-2908
Number of pages5
JournalDigestive Diseases and Sciences
Volume53
Issue number11
DOIs
Publication statusPublished - 01-11-2008

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Mannose-Binding Lectin
Stomach Neoplasms
Population
Codon
Genes
Exons
Odds Ratio
Confidence Intervals
Helicobacter Infections
Helicobacter pylori
Restriction Fragment Length Polymorphisms
Immune System
Healthy Volunteers
Cohort Studies
Alleles
Genotype
Phenotype
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

Wang, F. Y., Tahara, T., Arisawa, T., Shibata, T., Yamashita, H., Nakamura, M., ... Hirata, I. (2008). Mannan-binding lectin (MBL) polymorphism and gastric cancer risk in Japanese population. Digestive Diseases and Sciences, 53(11), 2904-2908. https://doi.org/10.1007/s10620-008-0249-3
Wang, Fang Yu ; Tahara, Tomomitsu ; Arisawa, Tomiyasu ; Shibata, Tomoyuki ; Yamashita, Hiromi ; Nakamura, Masakatsu ; Yoshioka, Daisuke ; Okubo, Masaaki ; Maruyama, Naoko ; Kamano, Toshiaki ; Kamiya, Yoshio ; Nakamura, Masahiko ; Fujita, Hiroshi ; Nagasaka, Mitsuo ; Iwata, Masami ; Takahama, Kazuya ; Watanabe, Makoto ; Nakano, Hiroshi ; Hirata, Ichiro. / Mannan-binding lectin (MBL) polymorphism and gastric cancer risk in Japanese population. In: Digestive Diseases and Sciences. 2008 ; Vol. 53, No. 11. pp. 2904-2908.
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title = "Mannan-binding lectin (MBL) polymorphism and gastric cancer risk in Japanese population",
abstract = "Background: Mannan-binding lectin (MBL) is believed to be an important constituent of the innate immune system. It has been reported that the codon 54 G/A polymorphism of exon-1 affects the MBL2 gene and alters its activity. Aims: We investigated the association between polymorphism of the MBL2 gene and gastric cancer risk as well as Helicobacter pylori infection in a Japanese population. Methods: The study cohort comprised 388 gastric cancer patients and 144 healthy volunteers. Polymorphism at codon 54 of exon 1 of the MBL2 gene was investigated by PCR-based restriction fragment length polymorphism analysis. Results: There was no significant difference in the distribution of the MBL2 genotype among the gastric cancer patients and healthy controls. However, the carrier of the A allele was more prevalent among patients with a more advanced stage gastric cancer [odds ratio (OR) 1.68, 95{\%} confidence interval (CI) 1.05-2.67; P = 0.03] and also had an increased risk of gastric cancer among patients 65 years of age or younger (OR = 1.6, 95{\%}CI = 1.01-2.52, <0.05). Conclusion: The codon 54 polymorphism of the MBL2 gene is associated with more advanced phenotypes of gastric cancer and the risk of gastric cancer in Japanese patients 65 years of age or younger.",
author = "Wang, {Fang Yu} and Tomomitsu Tahara and Tomiyasu Arisawa and Tomoyuki Shibata and Hiromi Yamashita and Masakatsu Nakamura and Daisuke Yoshioka and Masaaki Okubo and Naoko Maruyama and Toshiaki Kamano and Yoshio Kamiya and Masahiko Nakamura and Hiroshi Fujita and Mitsuo Nagasaka and Masami Iwata and Kazuya Takahama and Makoto Watanabe and Hiroshi Nakano and Ichiro Hirata",
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Wang, FY, Tahara, T, Arisawa, T, Shibata, T, Yamashita, H, Nakamura, M, Yoshioka, D, Okubo, M, Maruyama, N, Kamano, T, Kamiya, Y, Nakamura, M, Fujita, H, Nagasaka, M, Iwata, M, Takahama, K, Watanabe, M, Nakano, H & Hirata, I 2008, 'Mannan-binding lectin (MBL) polymorphism and gastric cancer risk in Japanese population', Digestive Diseases and Sciences, vol. 53, no. 11, pp. 2904-2908. https://doi.org/10.1007/s10620-008-0249-3

Mannan-binding lectin (MBL) polymorphism and gastric cancer risk in Japanese population. / Wang, Fang Yu; Tahara, Tomomitsu; Arisawa, Tomiyasu; Shibata, Tomoyuki; Yamashita, Hiromi; Nakamura, Masakatsu; Yoshioka, Daisuke; Okubo, Masaaki; Maruyama, Naoko; Kamano, Toshiaki; Kamiya, Yoshio; Nakamura, Masahiko; Fujita, Hiroshi; Nagasaka, Mitsuo; Iwata, Masami; Takahama, Kazuya; Watanabe, Makoto; Nakano, Hiroshi; Hirata, Ichiro.

In: Digestive Diseases and Sciences, Vol. 53, No. 11, 01.11.2008, p. 2904-2908.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Mannan-binding lectin (MBL) polymorphism and gastric cancer risk in Japanese population

AU - Wang, Fang Yu

AU - Tahara, Tomomitsu

AU - Arisawa, Tomiyasu

AU - Shibata, Tomoyuki

AU - Yamashita, Hiromi

AU - Nakamura, Masakatsu

AU - Yoshioka, Daisuke

AU - Okubo, Masaaki

AU - Maruyama, Naoko

AU - Kamano, Toshiaki

AU - Kamiya, Yoshio

AU - Nakamura, Masahiko

AU - Fujita, Hiroshi

AU - Nagasaka, Mitsuo

AU - Iwata, Masami

AU - Takahama, Kazuya

AU - Watanabe, Makoto

AU - Nakano, Hiroshi

AU - Hirata, Ichiro

PY - 2008/11/1

Y1 - 2008/11/1

N2 - Background: Mannan-binding lectin (MBL) is believed to be an important constituent of the innate immune system. It has been reported that the codon 54 G/A polymorphism of exon-1 affects the MBL2 gene and alters its activity. Aims: We investigated the association between polymorphism of the MBL2 gene and gastric cancer risk as well as Helicobacter pylori infection in a Japanese population. Methods: The study cohort comprised 388 gastric cancer patients and 144 healthy volunteers. Polymorphism at codon 54 of exon 1 of the MBL2 gene was investigated by PCR-based restriction fragment length polymorphism analysis. Results: There was no significant difference in the distribution of the MBL2 genotype among the gastric cancer patients and healthy controls. However, the carrier of the A allele was more prevalent among patients with a more advanced stage gastric cancer [odds ratio (OR) 1.68, 95% confidence interval (CI) 1.05-2.67; P = 0.03] and also had an increased risk of gastric cancer among patients 65 years of age or younger (OR = 1.6, 95%CI = 1.01-2.52, <0.05). Conclusion: The codon 54 polymorphism of the MBL2 gene is associated with more advanced phenotypes of gastric cancer and the risk of gastric cancer in Japanese patients 65 years of age or younger.

AB - Background: Mannan-binding lectin (MBL) is believed to be an important constituent of the innate immune system. It has been reported that the codon 54 G/A polymorphism of exon-1 affects the MBL2 gene and alters its activity. Aims: We investigated the association between polymorphism of the MBL2 gene and gastric cancer risk as well as Helicobacter pylori infection in a Japanese population. Methods: The study cohort comprised 388 gastric cancer patients and 144 healthy volunteers. Polymorphism at codon 54 of exon 1 of the MBL2 gene was investigated by PCR-based restriction fragment length polymorphism analysis. Results: There was no significant difference in the distribution of the MBL2 genotype among the gastric cancer patients and healthy controls. However, the carrier of the A allele was more prevalent among patients with a more advanced stage gastric cancer [odds ratio (OR) 1.68, 95% confidence interval (CI) 1.05-2.67; P = 0.03] and also had an increased risk of gastric cancer among patients 65 years of age or younger (OR = 1.6, 95%CI = 1.01-2.52, <0.05). Conclusion: The codon 54 polymorphism of the MBL2 gene is associated with more advanced phenotypes of gastric cancer and the risk of gastric cancer in Japanese patients 65 years of age or younger.

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U2 - 10.1007/s10620-008-0249-3

DO - 10.1007/s10620-008-0249-3

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EP - 2908

JO - American Journal of Digestive Diseases

JF - American Journal of Digestive Diseases

SN - 0002-9211

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