Mannosidase, alpha, class 2a2 (MAN2A2)

Michiko N. Fukuda, Kazuhiro Sugihara, Tomoya O. Akama

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Many proteins synthesized through the secretory pathway are posttranslationally modified by N-glycosylation. Alpha-mannosidase II (MAN2A1) and alpha-mannosidase IIx (MAN2A2) are key enzymes that convert precursor high mannose-type N-glycans to mature complex-type structures. While alpha-mannosidase II activity had been characterized by the time the mechanism of N-glycan processing was recognized (Kornfeld and Kornfeld 1985), investigators did not discover an alternative processing pathway until Man2a1 null mutant mice were generated and found capable of synthesizing complex-type N-glycans (Chui et al. 1997). Man2a2 then became a candidate for mediating that alternate pathway of N-glycan synthesis, but support for the pathway was lacking until creation of Man2a1/Man2a2 double knockout mice, which showed a complete loss in the ability to synthesize complex-type N-glycans (Fig. 117.1) (Akama et al. 2006).

Original languageEnglish
Title of host publicationHandbook of Glycosyltransferases and Related Genes, Second Edition
PublisherSpringer Japan
Pages1327-1333
Number of pages7
Volume2
ISBN (Electronic)9784431542407
ISBN (Print)9784431542391
DOIs
Publication statusPublished - 01-01-2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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