TY - JOUR
T1 - Mantle cell lymphoma with a unique pattern of CD5 expression
T2 - a case report with review of the literatures
AU - Yamada, Toshiki
AU - Goto, Naoe
AU - Tsurumi, Hisashi
AU - Takata, Katsuyoshi
AU - Sato, Yasuharu
AU - Yoshino, Tadashi
AU - Moriwaki, Hisataka
AU - Kito, Yusuke
AU - Takeuchi, Tamotsu
AU - Iwata, Hitoshi
N1 - Publisher Copyright:
© 2013, The Japanese Society for Clinical Molecular Morphology.
PY - 2013/9
Y1 - 2013/9
N2 - Mantle cell lymphoma (MCL) is a unique subtype of B-cell non-Hodgkin’s lymphoma characterized by chromosomal translocation t(11;14)(q13;q32), positive CD5, and nuclear cyclin D1 overexpression with unfavorable prognosis. We report herein a case of MCL in a 73-year-old male diagnosed with diffuse large B-cell lymphoma (ileal tumor) at another hospital, who subsequently relapsed with CD5-negative MCL. At the 1st relapse, he developed neck lymph node swelling, of which biopsy showed proliferation of atypical large pleomorphic cells with CD5-negativity by both immunohistochemistry and flow cytometry. At the 2nd relapse, he again developed an ileal tumor, of which biopsy showed positivity for CD5, CD20, and cyclin D1. In MCL, CD5-negative expression has sometimes been reported as having pleomorphic and blastoid variants. The present case was also histologically the pleomorphic type, but the CD5 expression changed from negative at the onset and the 1st relapse to positive at the 2nd relapse. This is a rare and interesting case because of the different expression of CD5 at all stage. This phenomenon made the diagnosis of MCL difficult.
AB - Mantle cell lymphoma (MCL) is a unique subtype of B-cell non-Hodgkin’s lymphoma characterized by chromosomal translocation t(11;14)(q13;q32), positive CD5, and nuclear cyclin D1 overexpression with unfavorable prognosis. We report herein a case of MCL in a 73-year-old male diagnosed with diffuse large B-cell lymphoma (ileal tumor) at another hospital, who subsequently relapsed with CD5-negative MCL. At the 1st relapse, he developed neck lymph node swelling, of which biopsy showed proliferation of atypical large pleomorphic cells with CD5-negativity by both immunohistochemistry and flow cytometry. At the 2nd relapse, he again developed an ileal tumor, of which biopsy showed positivity for CD5, CD20, and cyclin D1. In MCL, CD5-negative expression has sometimes been reported as having pleomorphic and blastoid variants. The present case was also histologically the pleomorphic type, but the CD5 expression changed from negative at the onset and the 1st relapse to positive at the 2nd relapse. This is a rare and interesting case because of the different expression of CD5 at all stage. This phenomenon made the diagnosis of MCL difficult.
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U2 - 10.1007/s00795-013-0060-x
DO - 10.1007/s00795-013-0060-x
M3 - Article
C2 - 24166616
AN - SCOPUS:84944224865
SN - 1860-1480
VL - 47
SP - 169
EP - 175
JO - Medical Molecular Morphology
JF - Medical Molecular Morphology
IS - 3
ER -