Mapping of two genetic loci, Ten-1 and Ten-2, associated with thymus enlargement in BUF/Mna rats

Y. Murakumo; M. Takahashi; N. Sharma; A. Arakawa; M. Saito; H. Amo; M. Matsuyama

doi:10.1007/s003359900152

Mapping of two genetic loci, Ten-1 and Ten-2, associated with thymus enlargement in BUF/Mna rats

Y. Murakumo
, M. Takahashi
, N. Sharma
, A. Arakawa
, M. Saito
, H. Amo
, M. Matsuyama

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The thymoma-prone BUF/Mna rat is a useful model for human thymoma. Thymoma develops spontaneously in these rats at an incidence of nearly 100%. At pre-thymoma age, BUF/Mna rats have extremely large thymuses when compared with those of rats of the other strains, suggesting the presence of genes that regulate the thymus enlargement. We performed linkage study to identify the genetic loci associated with thymus enlargement in {(WKY/NCrj x BUF/Mna) F₁ x BUF/Mna} backcross rats. Linkage study showed the significant associations between thymus size and markers on Chromosomes (Chrs) 1 and 13, suggesting the presence of two genes. Ten-1 and Ten-2, which regulate the thymus enlargement. Ten-1 was located between myosin light chain, muscle 2 (MYL2) and D1Mgh11 loci on Chr 1, and Ten-2 was located between synaptotagmin II (SYT2) and D13N2 loci on Chr 13.

Original language	English
Pages (from-to)	505-508
Number of pages	4
Journal	Mammalian Genome
Volume	7
Issue number	7
DOIs	https://doi.org/10.1007/s003359900152
Publication status	Published - 1996
Externally published	Yes

All Science Journal Classification (ASJC) codes

Genetics

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10.1007/s003359900152

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@article{425634a36b8d483db12ee918a0f2d797,

title = "Mapping of two genetic loci, Ten-1 and Ten-2, associated with thymus enlargement in BUF/Mna rats",

abstract = "The thymoma-prone BUF/Mna rat is a useful model for human thymoma. Thymoma develops spontaneously in these rats at an incidence of nearly 100\%. At pre-thymoma age, BUF/Mna rats have extremely large thymuses when compared with those of rats of the other strains, suggesting the presence of genes that regulate the thymus enlargement. We performed linkage study to identify the genetic loci associated with thymus enlargement in \{(WKY/NCrj x BUF/Mna) F1 x BUF/Mna\} backcross rats. Linkage study showed the significant associations between thymus size and markers on Chromosomes (Chrs) 1 and 13, suggesting the presence of two genes. Ten-1 and Ten-2, which regulate the thymus enlargement. Ten-1 was located between myosin light chain, muscle 2 (MYL2) and D1Mgh11 loci on Chr 1, and Ten-2 was located between synaptotagmin II (SYT2) and D13N2 loci on Chr 13.",

author = "Y. Murakumo and M. Takahashi and N. Sharma and A. Arakawa and M. Saito and H. Amo and M. Matsuyama",

year = "1996",

doi = "10.1007/s003359900152",

language = "English",

volume = "7",

pages = "505--508",

journal = "Mammalian Genome",

issn = "0938-8990",

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}

TY - JOUR

T1 - Mapping of two genetic loci, Ten-1 and Ten-2, associated with thymus enlargement in BUF/Mna rats

AU - Murakumo, Y.

AU - Takahashi, M.

AU - Sharma, N.

AU - Arakawa, A.

AU - Saito, M.

AU - Amo, H.

AU - Matsuyama, M.

PY - 1996

Y1 - 1996

N2 - The thymoma-prone BUF/Mna rat is a useful model for human thymoma. Thymoma develops spontaneously in these rats at an incidence of nearly 100%. At pre-thymoma age, BUF/Mna rats have extremely large thymuses when compared with those of rats of the other strains, suggesting the presence of genes that regulate the thymus enlargement. We performed linkage study to identify the genetic loci associated with thymus enlargement in {(WKY/NCrj x BUF/Mna) F1 x BUF/Mna} backcross rats. Linkage study showed the significant associations between thymus size and markers on Chromosomes (Chrs) 1 and 13, suggesting the presence of two genes. Ten-1 and Ten-2, which regulate the thymus enlargement. Ten-1 was located between myosin light chain, muscle 2 (MYL2) and D1Mgh11 loci on Chr 1, and Ten-2 was located between synaptotagmin II (SYT2) and D13N2 loci on Chr 13.

AB - The thymoma-prone BUF/Mna rat is a useful model for human thymoma. Thymoma develops spontaneously in these rats at an incidence of nearly 100%. At pre-thymoma age, BUF/Mna rats have extremely large thymuses when compared with those of rats of the other strains, suggesting the presence of genes that regulate the thymus enlargement. We performed linkage study to identify the genetic loci associated with thymus enlargement in {(WKY/NCrj x BUF/Mna) F1 x BUF/Mna} backcross rats. Linkage study showed the significant associations between thymus size and markers on Chromosomes (Chrs) 1 and 13, suggesting the presence of two genes. Ten-1 and Ten-2, which regulate the thymus enlargement. Ten-1 was located between myosin light chain, muscle 2 (MYL2) and D1Mgh11 loci on Chr 1, and Ten-2 was located between synaptotagmin II (SYT2) and D13N2 loci on Chr 13.

UR - https://www.scopus.com/pages/publications/0030188229

UR - https://www.scopus.com/pages/publications/0030188229#tab=citedBy

U2 - 10.1007/s003359900152

DO - 10.1007/s003359900152

M3 - Article

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AN - SCOPUS:0030188229

SN - 0938-8990

VL - 7

SP - 505

EP - 508

JO - Mammalian Genome

JF - Mammalian Genome

IS - 7

ER -

Mapping of two genetic loci, Ten-1 and Ten-2, associated with thymus enlargement in BUF/Mna rats

Abstract

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