Marked reduction of mouse peritoneal CD5+ B cells by intraperitoneal administration of lipopolysaccharide

Noriko Paeng, Nobuo Kido, Yutaka Kato, Tsuyoshi Sugiyama, Naoki Koide, Makoto Naruse, Guo Zhi Jiang, Tint Lwin, Tomoaki Yoshida, Takashi Yokochi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Intraperitoneal administration of lipopolysaccharide to mice induced a marked reduction of CD5+ B cells in the peritoneal cavity. The reduction was not induced by intravenous, subcutaneous, or oral administration of lipopolysaccharide. The reduction continued for about 10 days after the injection, and the CD5+ B-cell count recovered to the normal state about 14 days after the injection. The reduction of peritoneal CD5+ B cells might be caused by apoptotic cell death. Injection of lipopolysaccharide did not result in production of antibody to lipopolysaccharide. On the other hand, intraperitoneal injection of heat-killed bacteria did not induce a reduction of peritoneal CD5+ B cells and elicited the definite production of antibody to lipopolysaccharide.

Original languageEnglish
Pages (from-to)122-126
Number of pages5
JournalInfection and Immunity
Volume65
Issue number1
DOIs
Publication statusPublished - 01-1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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