Maternal high-fructose intake increases circulating corticosterone levels via decreased adrenal corticosterone clearance in adult offspring

Eiji Munetsuna, Hiroya Yamada, Mirai Yamazaki, Yoshitaka Ando, Genki Mizuno, Yuji Hattori, Nao Sadamoto, Hiroaki Ishikawa, Yoshiji Ohta, Ryosuke Fujii, Koji Suzuki, Shuji Hashimoto, Koji Ohashi

Research output: Contribution to journalArticle

Abstract

Global fructose consumption is on the rise; however, maternal high-fructose intake may have adverse effects on offspring. We previously demonstrated that excessive fructose intake by rat dams altered steroidogenic gene transcription in the hippocampus of offspring. Herein, we examined how maternal high-fructose intake influences the regulation of adrenal glucocorticoid levels in offspring. Rat dams received 20% fructose solution during gestation and lactation. After weaning, the offspring were provided normal water. Maternal high-fructose intake did not alter mRNA expression levels of adrenal corticosterone-synthesizing and corticosterone-inactivating proteins or the circulating adrenocorticotropic hormone levels of offspring at postnatal day (PD) 21; however, it increased circulating corticosterone levels and decreased mRNA and protein levels of adrenal 5α-reductase type 1 and 11β-hydroxysteroid dehydrogenase type 2 in offspring at PD160. Furthermore, maternal high-fructose intake enhanced DNA methylation of the adrenal 5α-reductase 1 promoter region in PD160 offspring. Thus, maternal high-fructose intake was found to affect adrenal steroid hormone clearance in adult offspring — at least in part — through epigenetic mechanisms.

Original languageEnglish
Pages (from-to)44-50
Number of pages7
JournalJournal of Nutritional Biochemistry
Volume67
DOIs
Publication statusPublished - 01-05-2019

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Corticosterone
Fructose
Mothers
Dams
Rats
Oxidoreductases
Steroid hormones
11-beta-Hydroxysteroid Dehydrogenases
Messenger RNA
DNA Methylation
Transcription
Weaning
Lactation
Genetic Promoter Regions
Epigenomics
Adrenocorticotropic Hormone
Glucocorticoids
Hippocampus
Proteins
Genes

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology
  • Nutrition and Dietetics
  • Clinical Biochemistry

Cite this

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title = "Maternal high-fructose intake increases circulating corticosterone levels via decreased adrenal corticosterone clearance in adult offspring",
abstract = "Global fructose consumption is on the rise; however, maternal high-fructose intake may have adverse effects on offspring. We previously demonstrated that excessive fructose intake by rat dams altered steroidogenic gene transcription in the hippocampus of offspring. Herein, we examined how maternal high-fructose intake influences the regulation of adrenal glucocorticoid levels in offspring. Rat dams received 20{\%} fructose solution during gestation and lactation. After weaning, the offspring were provided normal water. Maternal high-fructose intake did not alter mRNA expression levels of adrenal corticosterone-synthesizing and corticosterone-inactivating proteins or the circulating adrenocorticotropic hormone levels of offspring at postnatal day (PD) 21; however, it increased circulating corticosterone levels and decreased mRNA and protein levels of adrenal 5α-reductase type 1 and 11β-hydroxysteroid dehydrogenase type 2 in offspring at PD160. Furthermore, maternal high-fructose intake enhanced DNA methylation of the adrenal 5α-reductase 1 promoter region in PD160 offspring. Thus, maternal high-fructose intake was found to affect adrenal steroid hormone clearance in adult offspring — at least in part — through epigenetic mechanisms.",
author = "Eiji Munetsuna and Hiroya Yamada and Mirai Yamazaki and Yoshitaka Ando and Genki Mizuno and Yuji Hattori and Nao Sadamoto and Hiroaki Ishikawa and Yoshiji Ohta and Ryosuke Fujii and Koji Suzuki and Shuji Hashimoto and Koji Ohashi",
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Maternal high-fructose intake increases circulating corticosterone levels via decreased adrenal corticosterone clearance in adult offspring. / Munetsuna, Eiji; Yamada, Hiroya; Yamazaki, Mirai; Ando, Yoshitaka; Mizuno, Genki; Hattori, Yuji; Sadamoto, Nao; Ishikawa, Hiroaki; Ohta, Yoshiji; Fujii, Ryosuke; Suzuki, Koji; Hashimoto, Shuji; Ohashi, Koji.

In: Journal of Nutritional Biochemistry, Vol. 67, 01.05.2019, p. 44-50.

Research output: Contribution to journalArticle

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T1 - Maternal high-fructose intake increases circulating corticosterone levels via decreased adrenal corticosterone clearance in adult offspring

AU - Munetsuna, Eiji

AU - Yamada, Hiroya

AU - Yamazaki, Mirai

AU - Ando, Yoshitaka

AU - Mizuno, Genki

AU - Hattori, Yuji

AU - Sadamoto, Nao

AU - Ishikawa, Hiroaki

AU - Ohta, Yoshiji

AU - Fujii, Ryosuke

AU - Suzuki, Koji

AU - Hashimoto, Shuji

AU - Ohashi, Koji

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Global fructose consumption is on the rise; however, maternal high-fructose intake may have adverse effects on offspring. We previously demonstrated that excessive fructose intake by rat dams altered steroidogenic gene transcription in the hippocampus of offspring. Herein, we examined how maternal high-fructose intake influences the regulation of adrenal glucocorticoid levels in offspring. Rat dams received 20% fructose solution during gestation and lactation. After weaning, the offspring were provided normal water. Maternal high-fructose intake did not alter mRNA expression levels of adrenal corticosterone-synthesizing and corticosterone-inactivating proteins or the circulating adrenocorticotropic hormone levels of offspring at postnatal day (PD) 21; however, it increased circulating corticosterone levels and decreased mRNA and protein levels of adrenal 5α-reductase type 1 and 11β-hydroxysteroid dehydrogenase type 2 in offspring at PD160. Furthermore, maternal high-fructose intake enhanced DNA methylation of the adrenal 5α-reductase 1 promoter region in PD160 offspring. Thus, maternal high-fructose intake was found to affect adrenal steroid hormone clearance in adult offspring — at least in part — through epigenetic mechanisms.

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