Matrix metalloproteinase-9 gene polymorphisms and chronic kidney disease

Rieko Okada, Sayo Kawai, Mariko Naito, Asahi Hishida, Nobuyuki Hamajima, Koichi Shinchi, Tanvir Chowdhury Turin, Sadao Suzuki, Eva Mariane Mantjoro, Kengo Toyomura, Kokichi Arisawa, Nagato Kuriyama, Satoyo Hosono, Haruo Mikami, Michiaki Kubo, Hideo Tanaka, Kenji Wakai

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: The aim of this study was to explore the associations between the prevalence of chronic kidney disease (CKD) and polymorphisms in the genes encoding matrix metalloproteinases (MMPs) and tissue inhibitor of matrix metalloproteinases (TIMPs). MMPs degrade extracellular matrix proteins in the glomerulus, and play important roles in kidney disease progression. Methods: DNA samples from 3,309 subjects aged 35-69 years were genotyped for 10 potentially functional polymorphisms in MMP and TIMP genes. The prevalence of CKD (estimated glomerular filtration rate <60 ml/min/1.73 m2) was compared among the genotypes. Results: The prevalence of CKD decreased significantly with the number of minor alleles in MMP9 C-1562T (odds ratios (ORs) 0.77 for CT and 0.65 for TT compared with CC; p for trend = 0.023) and MMP9 R668Q (ORs, 0.79 for RQ and 0.64 for QQ compared with RR; p for trend = 0.024). The haplotype MMP9-1562T/279R/668Q showed a reduced risk for CKD compared with the most common-1562C/279R/668R (OR 0.77, p = 0.008), and the genotype combination-1562TT/279RR/668QQ showed a halved risk for CKD compared with major allele homozygous-1562CC/279RR/668RR (OR 0.53, p = 0.091). Conclusion: The potentially functional polymorphisms of MMP9 were associated with the prevalence of CKD in a large Japanese population. These genotypes have been reported to increase MMP9 expression, supporting the hypothesis that MMP-9 has a protective role in the progression of kidney diseases.

Original languageEnglish
Pages (from-to)444-450
Number of pages7
JournalAmerican Journal of Nephrology
Volume36
Issue number5
DOIs
Publication statusPublished - 01-11-2012

Fingerprint

Matrix Metalloproteinase 9
Chronic Renal Insufficiency
Matrix Metalloproteinases
Odds Ratio
Genes
Tissue Inhibitor of Metalloproteinases
Matrix Metalloproteinase Inhibitors
Genotype
Kidney Diseases
Alleles
Extracellular Matrix Proteins
Glomerular Filtration Rate
Haplotypes
Disease Progression
DNA
Population

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Okada, R., Kawai, S., Naito, M., Hishida, A., Hamajima, N., Shinchi, K., ... Wakai, K. (2012). Matrix metalloproteinase-9 gene polymorphisms and chronic kidney disease. American Journal of Nephrology, 36(5), 444-450. https://doi.org/10.1159/000343742
Okada, Rieko ; Kawai, Sayo ; Naito, Mariko ; Hishida, Asahi ; Hamajima, Nobuyuki ; Shinchi, Koichi ; Chowdhury Turin, Tanvir ; Suzuki, Sadao ; Mantjoro, Eva Mariane ; Toyomura, Kengo ; Arisawa, Kokichi ; Kuriyama, Nagato ; Hosono, Satoyo ; Mikami, Haruo ; Kubo, Michiaki ; Tanaka, Hideo ; Wakai, Kenji. / Matrix metalloproteinase-9 gene polymorphisms and chronic kidney disease. In: American Journal of Nephrology. 2012 ; Vol. 36, No. 5. pp. 444-450.
@article{3d941bad32af43fb820ac5765b2bec6b,
title = "Matrix metalloproteinase-9 gene polymorphisms and chronic kidney disease",
abstract = "Background: The aim of this study was to explore the associations between the prevalence of chronic kidney disease (CKD) and polymorphisms in the genes encoding matrix metalloproteinases (MMPs) and tissue inhibitor of matrix metalloproteinases (TIMPs). MMPs degrade extracellular matrix proteins in the glomerulus, and play important roles in kidney disease progression. Methods: DNA samples from 3,309 subjects aged 35-69 years were genotyped for 10 potentially functional polymorphisms in MMP and TIMP genes. The prevalence of CKD (estimated glomerular filtration rate <60 ml/min/1.73 m2) was compared among the genotypes. Results: The prevalence of CKD decreased significantly with the number of minor alleles in MMP9 C-1562T (odds ratios (ORs) 0.77 for CT and 0.65 for TT compared with CC; p for trend = 0.023) and MMP9 R668Q (ORs, 0.79 for RQ and 0.64 for QQ compared with RR; p for trend = 0.024). The haplotype MMP9-1562T/279R/668Q showed a reduced risk for CKD compared with the most common-1562C/279R/668R (OR 0.77, p = 0.008), and the genotype combination-1562TT/279RR/668QQ showed a halved risk for CKD compared with major allele homozygous-1562CC/279RR/668RR (OR 0.53, p = 0.091). Conclusion: The potentially functional polymorphisms of MMP9 were associated with the prevalence of CKD in a large Japanese population. These genotypes have been reported to increase MMP9 expression, supporting the hypothesis that MMP-9 has a protective role in the progression of kidney diseases.",
author = "Rieko Okada and Sayo Kawai and Mariko Naito and Asahi Hishida and Nobuyuki Hamajima and Koichi Shinchi and {Chowdhury Turin}, Tanvir and Sadao Suzuki and Mantjoro, {Eva Mariane} and Kengo Toyomura and Kokichi Arisawa and Nagato Kuriyama and Satoyo Hosono and Haruo Mikami and Michiaki Kubo and Hideo Tanaka and Kenji Wakai",
year = "2012",
month = "11",
day = "1",
doi = "10.1159/000343742",
language = "English",
volume = "36",
pages = "444--450",
journal = "American Journal of Nephrology",
issn = "0250-8095",
publisher = "S. Karger AG",
number = "5",

}

Okada, R, Kawai, S, Naito, M, Hishida, A, Hamajima, N, Shinchi, K, Chowdhury Turin, T, Suzuki, S, Mantjoro, EM, Toyomura, K, Arisawa, K, Kuriyama, N, Hosono, S, Mikami, H, Kubo, M, Tanaka, H & Wakai, K 2012, 'Matrix metalloproteinase-9 gene polymorphisms and chronic kidney disease', American Journal of Nephrology, vol. 36, no. 5, pp. 444-450. https://doi.org/10.1159/000343742

Matrix metalloproteinase-9 gene polymorphisms and chronic kidney disease. / Okada, Rieko; Kawai, Sayo; Naito, Mariko; Hishida, Asahi; Hamajima, Nobuyuki; Shinchi, Koichi; Chowdhury Turin, Tanvir; Suzuki, Sadao; Mantjoro, Eva Mariane; Toyomura, Kengo; Arisawa, Kokichi; Kuriyama, Nagato; Hosono, Satoyo; Mikami, Haruo; Kubo, Michiaki; Tanaka, Hideo; Wakai, Kenji.

In: American Journal of Nephrology, Vol. 36, No. 5, 01.11.2012, p. 444-450.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Matrix metalloproteinase-9 gene polymorphisms and chronic kidney disease

AU - Okada, Rieko

AU - Kawai, Sayo

AU - Naito, Mariko

AU - Hishida, Asahi

AU - Hamajima, Nobuyuki

AU - Shinchi, Koichi

AU - Chowdhury Turin, Tanvir

AU - Suzuki, Sadao

AU - Mantjoro, Eva Mariane

AU - Toyomura, Kengo

AU - Arisawa, Kokichi

AU - Kuriyama, Nagato

AU - Hosono, Satoyo

AU - Mikami, Haruo

AU - Kubo, Michiaki

AU - Tanaka, Hideo

AU - Wakai, Kenji

PY - 2012/11/1

Y1 - 2012/11/1

N2 - Background: The aim of this study was to explore the associations between the prevalence of chronic kidney disease (CKD) and polymorphisms in the genes encoding matrix metalloproteinases (MMPs) and tissue inhibitor of matrix metalloproteinases (TIMPs). MMPs degrade extracellular matrix proteins in the glomerulus, and play important roles in kidney disease progression. Methods: DNA samples from 3,309 subjects aged 35-69 years were genotyped for 10 potentially functional polymorphisms in MMP and TIMP genes. The prevalence of CKD (estimated glomerular filtration rate <60 ml/min/1.73 m2) was compared among the genotypes. Results: The prevalence of CKD decreased significantly with the number of minor alleles in MMP9 C-1562T (odds ratios (ORs) 0.77 for CT and 0.65 for TT compared with CC; p for trend = 0.023) and MMP9 R668Q (ORs, 0.79 for RQ and 0.64 for QQ compared with RR; p for trend = 0.024). The haplotype MMP9-1562T/279R/668Q showed a reduced risk for CKD compared with the most common-1562C/279R/668R (OR 0.77, p = 0.008), and the genotype combination-1562TT/279RR/668QQ showed a halved risk for CKD compared with major allele homozygous-1562CC/279RR/668RR (OR 0.53, p = 0.091). Conclusion: The potentially functional polymorphisms of MMP9 were associated with the prevalence of CKD in a large Japanese population. These genotypes have been reported to increase MMP9 expression, supporting the hypothesis that MMP-9 has a protective role in the progression of kidney diseases.

AB - Background: The aim of this study was to explore the associations between the prevalence of chronic kidney disease (CKD) and polymorphisms in the genes encoding matrix metalloproteinases (MMPs) and tissue inhibitor of matrix metalloproteinases (TIMPs). MMPs degrade extracellular matrix proteins in the glomerulus, and play important roles in kidney disease progression. Methods: DNA samples from 3,309 subjects aged 35-69 years were genotyped for 10 potentially functional polymorphisms in MMP and TIMP genes. The prevalence of CKD (estimated glomerular filtration rate <60 ml/min/1.73 m2) was compared among the genotypes. Results: The prevalence of CKD decreased significantly with the number of minor alleles in MMP9 C-1562T (odds ratios (ORs) 0.77 for CT and 0.65 for TT compared with CC; p for trend = 0.023) and MMP9 R668Q (ORs, 0.79 for RQ and 0.64 for QQ compared with RR; p for trend = 0.024). The haplotype MMP9-1562T/279R/668Q showed a reduced risk for CKD compared with the most common-1562C/279R/668R (OR 0.77, p = 0.008), and the genotype combination-1562TT/279RR/668QQ showed a halved risk for CKD compared with major allele homozygous-1562CC/279RR/668RR (OR 0.53, p = 0.091). Conclusion: The potentially functional polymorphisms of MMP9 were associated with the prevalence of CKD in a large Japanese population. These genotypes have been reported to increase MMP9 expression, supporting the hypothesis that MMP-9 has a protective role in the progression of kidney diseases.

UR - http://www.scopus.com/inward/record.url?scp=84868233259&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868233259&partnerID=8YFLogxK

U2 - 10.1159/000343742

DO - 10.1159/000343742

M3 - Article

C2 - 23128247

AN - SCOPUS:84868233259

VL - 36

SP - 444

EP - 450

JO - American Journal of Nephrology

JF - American Journal of Nephrology

SN - 0250-8095

IS - 5

ER -

Okada R, Kawai S, Naito M, Hishida A, Hamajima N, Shinchi K et al. Matrix metalloproteinase-9 gene polymorphisms and chronic kidney disease. American Journal of Nephrology. 2012 Nov 1;36(5):444-450. https://doi.org/10.1159/000343742