Matrix metalloproteinase 9 gene polymorphisms are associated with a multiple family history of gastric cancer

The Japan Multi-institutional Collaborative Cohort Study Group

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: A family history of gastric cancer (GC) is a well-known risk factor of GC. Genetic variations in genes of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have been related to the risk of GC, but their association with familial background is not clear. We investigated whether individuals with a multiple family history of GC have more risk genotypes of MMP/TIMP genes. Methods: We genotyped ten common functional polymorphisms of MMP/TIMP genes in 4427 individuals aged 35–69 years without a history of GC who were enrolled in the Japan Multi-institutional Collaborative Cohort Study. Individuals who have two or more first-degree relatives (parents and siblings) with GC were categorized as having a multiple family history. Odds ratios (ORs) for multiple family history compared with no family history were calculated. Results: MMP9 279QQ (rs17576) was more frequently observed in individuals whose both parents had a history of GC (n = 23) and in individuals for whom one parent and their sibling(s) had a history of GC (n = 36) compared with those with no family history (n = 3816) [30.4 % vs 11.6 %, OR 4.34, 95 % confidence interval (CI) 1.45–13.03 and 16.7 % vs 11.6 %, OR 2.26, 95 % CI 0.81–6.27 after adjustment for age, sex, and current smoking]. The population attributable fraction was 38.1 %. The haplotype MMP9-1562C/279Q/668Q was more frequently observed in individuals whose both parents had a history of GC and in individuals for whom one parent and their sibling(s) had a history of GC compared with those with no family history (OR 3.35, 95 % CI 0.75–14.96 and OR 3.51, 95 % CI 1.35–9.15 respectively). Conclusions: MMP9 polymorphisms were associated with a multiple family history of GC. Screening for these genotypes together with familial background may help us to identify individuals at an increased risk of GC.

Original languageEnglish
Pages (from-to)246-253
Number of pages8
JournalGastric Cancer
Volume20
Issue number2
DOIs
Publication statusPublished - 01-03-2017

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Stomach Neoplasms
Genes
Tissue Inhibitor of Metalloproteinases
Odds Ratio
Matrix Metalloproteinase Inhibitors
Confidence Intervals
Genotype
Haplotypes
Japan
Cohort Studies
Smoking

All Science Journal Classification (ASJC) codes

  • Oncology
  • Gastroenterology
  • Cancer Research

Cite this

The Japan Multi-institutional Collaborative Cohort Study Group. / Matrix metalloproteinase 9 gene polymorphisms are associated with a multiple family history of gastric cancer. In: Gastric Cancer. 2017 ; Vol. 20, No. 2. pp. 246-253.
@article{95acc0c3b2314be3954e6f932572e160,
title = "Matrix metalloproteinase 9 gene polymorphisms are associated with a multiple family history of gastric cancer",
abstract = "Background: A family history of gastric cancer (GC) is a well-known risk factor of GC. Genetic variations in genes of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have been related to the risk of GC, but their association with familial background is not clear. We investigated whether individuals with a multiple family history of GC have more risk genotypes of MMP/TIMP genes. Methods: We genotyped ten common functional polymorphisms of MMP/TIMP genes in 4427 individuals aged 35–69 years without a history of GC who were enrolled in the Japan Multi-institutional Collaborative Cohort Study. Individuals who have two or more first-degree relatives (parents and siblings) with GC were categorized as having a multiple family history. Odds ratios (ORs) for multiple family history compared with no family history were calculated. Results: MMP9 279QQ (rs17576) was more frequently observed in individuals whose both parents had a history of GC (n = 23) and in individuals for whom one parent and their sibling(s) had a history of GC (n = 36) compared with those with no family history (n = 3816) [30.4 {\%} vs 11.6 {\%}, OR 4.34, 95 {\%} confidence interval (CI) 1.45–13.03 and 16.7 {\%} vs 11.6 {\%}, OR 2.26, 95 {\%} CI 0.81–6.27 after adjustment for age, sex, and current smoking]. The population attributable fraction was 38.1 {\%}. The haplotype MMP9-1562C/279Q/668Q was more frequently observed in individuals whose both parents had a history of GC and in individuals for whom one parent and their sibling(s) had a history of GC compared with those with no family history (OR 3.35, 95 {\%} CI 0.75–14.96 and OR 3.51, 95 {\%} CI 1.35–9.15 respectively). Conclusions: MMP9 polymorphisms were associated with a multiple family history of GC. Screening for these genotypes together with familial background may help us to identify individuals at an increased risk of GC.",
author = "{The Japan Multi-institutional Collaborative Cohort Study Group} and Rieko Okada and Mariko Naito and Yuta Hattori and Toshio Seiki and Kenji Wakai and Hinako Nanri and Miki Watanabe and Sadao Suzuki and Kairupan, {Tara Sefanya} and Naoyuki Takashima and Haruo Mikami and Keizo Ohnaka and Yoshiyuki Watanabe and Sakurako Katsuura-Kamano and Michiaki Kubo and Nobuyuki Hamajima and Michiaki Kubo",
year = "2017",
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pages = "246--253",
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Matrix metalloproteinase 9 gene polymorphisms are associated with a multiple family history of gastric cancer. / The Japan Multi-institutional Collaborative Cohort Study Group.

In: Gastric Cancer, Vol. 20, No. 2, 01.03.2017, p. 246-253.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Matrix metalloproteinase 9 gene polymorphisms are associated with a multiple family history of gastric cancer

AU - The Japan Multi-institutional Collaborative Cohort Study Group

AU - Okada, Rieko

AU - Naito, Mariko

AU - Hattori, Yuta

AU - Seiki, Toshio

AU - Wakai, Kenji

AU - Nanri, Hinako

AU - Watanabe, Miki

AU - Suzuki, Sadao

AU - Kairupan, Tara Sefanya

AU - Takashima, Naoyuki

AU - Mikami, Haruo

AU - Ohnaka, Keizo

AU - Watanabe, Yoshiyuki

AU - Katsuura-Kamano, Sakurako

AU - Kubo, Michiaki

AU - Hamajima, Nobuyuki

AU - Kubo, Michiaki

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Background: A family history of gastric cancer (GC) is a well-known risk factor of GC. Genetic variations in genes of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have been related to the risk of GC, but their association with familial background is not clear. We investigated whether individuals with a multiple family history of GC have more risk genotypes of MMP/TIMP genes. Methods: We genotyped ten common functional polymorphisms of MMP/TIMP genes in 4427 individuals aged 35–69 years without a history of GC who were enrolled in the Japan Multi-institutional Collaborative Cohort Study. Individuals who have two or more first-degree relatives (parents and siblings) with GC were categorized as having a multiple family history. Odds ratios (ORs) for multiple family history compared with no family history were calculated. Results: MMP9 279QQ (rs17576) was more frequently observed in individuals whose both parents had a history of GC (n = 23) and in individuals for whom one parent and their sibling(s) had a history of GC (n = 36) compared with those with no family history (n = 3816) [30.4 % vs 11.6 %, OR 4.34, 95 % confidence interval (CI) 1.45–13.03 and 16.7 % vs 11.6 %, OR 2.26, 95 % CI 0.81–6.27 after adjustment for age, sex, and current smoking]. The population attributable fraction was 38.1 %. The haplotype MMP9-1562C/279Q/668Q was more frequently observed in individuals whose both parents had a history of GC and in individuals for whom one parent and their sibling(s) had a history of GC compared with those with no family history (OR 3.35, 95 % CI 0.75–14.96 and OR 3.51, 95 % CI 1.35–9.15 respectively). Conclusions: MMP9 polymorphisms were associated with a multiple family history of GC. Screening for these genotypes together with familial background may help us to identify individuals at an increased risk of GC.

AB - Background: A family history of gastric cancer (GC) is a well-known risk factor of GC. Genetic variations in genes of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have been related to the risk of GC, but their association with familial background is not clear. We investigated whether individuals with a multiple family history of GC have more risk genotypes of MMP/TIMP genes. Methods: We genotyped ten common functional polymorphisms of MMP/TIMP genes in 4427 individuals aged 35–69 years without a history of GC who were enrolled in the Japan Multi-institutional Collaborative Cohort Study. Individuals who have two or more first-degree relatives (parents and siblings) with GC were categorized as having a multiple family history. Odds ratios (ORs) for multiple family history compared with no family history were calculated. Results: MMP9 279QQ (rs17576) was more frequently observed in individuals whose both parents had a history of GC (n = 23) and in individuals for whom one parent and their sibling(s) had a history of GC (n = 36) compared with those with no family history (n = 3816) [30.4 % vs 11.6 %, OR 4.34, 95 % confidence interval (CI) 1.45–13.03 and 16.7 % vs 11.6 %, OR 2.26, 95 % CI 0.81–6.27 after adjustment for age, sex, and current smoking]. The population attributable fraction was 38.1 %. The haplotype MMP9-1562C/279Q/668Q was more frequently observed in individuals whose both parents had a history of GC and in individuals for whom one parent and their sibling(s) had a history of GC compared with those with no family history (OR 3.35, 95 % CI 0.75–14.96 and OR 3.51, 95 % CI 1.35–9.15 respectively). Conclusions: MMP9 polymorphisms were associated with a multiple family history of GC. Screening for these genotypes together with familial background may help us to identify individuals at an increased risk of GC.

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U2 - 10.1007/s10120-016-0608-2

DO - 10.1007/s10120-016-0608-2

M3 - Article

C2 - 27053167

AN - SCOPUS:84962684984

VL - 20

SP - 246

EP - 253

JO - Gastric Cancer

JF - Gastric Cancer

SN - 1436-3291

IS - 2

ER -