Matrix metalloproteinases and cartilage matrix degradation in rheumatoid arthritis

Yasuo Yoshihara, Harumoto Yamada

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)


Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder characterized by the progressive destruction of articular cartilage. Matrix metalloproteinases (MMPs) constitute a major group among the neutral proteinases that degrade the extracellular matrix of cartilage, including various types of collagen, and aggrecan. Various MMPs are highly produced in synovial fluid and in sera from patients with RA, and are reported to play a pivotal role in cartilage matrix degradation in RA. In this review we describe the members of the MMP family and their basic function, and discuss their role in cartilage destruction in RA.

Original languageEnglish
Pages (from-to)500-508
Number of pages9
JournalClinical calcium
Issue number4
Publication statusPublished - 04-2007

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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