Matrix metalloproteinases contribute to neuronal dysfunction in animal models of drug dependence, Alzheimer's disease, and epilepsy

Hiroyuki Mizoguchi, Kiyofumi Yamada, Toshitaka Nabeshima

Research output: Contribution to journalReview article

37 Citations (Scopus)

Abstract

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) remodel the pericellular environment by regulating the cleavage of extracellular matrix proteins, cell surface components, neurotransmitter receptors, and growth factors that mediate cell adhesion, synaptogenesis, synaptic plasticity, and long-term potentiation. Interestingly, increased MMP activity and dysregulation of the balance between MMPs and TIMPs have also been implicated in various pathologic conditions. In this paper, we discuss various animal models that suggest that the activation of the gelatinases MMP-2 and MMP-9 is involved in pathogenesis of drug dependence, Alzheimer's disease, and epilepsy.

Original languageEnglish
Article number681385
JournalBiochemistry Research International
DOIs
Publication statusPublished - 01-12-2011
Externally publishedYes

Fingerprint

Tissue Inhibitor of Metalloproteinases
Matrix Metalloproteinase Inhibitors
Matrix Metalloproteinases
Substance-Related Disorders
Epilepsy
Alzheimer Disease
Animals
Animal Models
Gelatinases
Neurotransmitter Receptor
Neuronal Plasticity
Long-Term Potentiation
Extracellular Matrix Proteins
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Cellular Structures
Cell Adhesion
Pharmaceutical Preparations
Intercellular Signaling Peptides and Proteins
Cell adhesion

All Science Journal Classification (ASJC) codes

  • Biochemistry

Cite this

@article{8fe8e914c5b3460ba27f09c8ab0696ec,
title = "Matrix metalloproteinases contribute to neuronal dysfunction in animal models of drug dependence, Alzheimer's disease, and epilepsy",
abstract = "Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) remodel the pericellular environment by regulating the cleavage of extracellular matrix proteins, cell surface components, neurotransmitter receptors, and growth factors that mediate cell adhesion, synaptogenesis, synaptic plasticity, and long-term potentiation. Interestingly, increased MMP activity and dysregulation of the balance between MMPs and TIMPs have also been implicated in various pathologic conditions. In this paper, we discuss various animal models that suggest that the activation of the gelatinases MMP-2 and MMP-9 is involved in pathogenesis of drug dependence, Alzheimer's disease, and epilepsy.",
author = "Hiroyuki Mizoguchi and Kiyofumi Yamada and Toshitaka Nabeshima",
year = "2011",
month = "12",
day = "1",
doi = "10.1155/2011/681385",
language = "English",
journal = "Biochemistry Research International",
issn = "2090-2247",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Matrix metalloproteinases contribute to neuronal dysfunction in animal models of drug dependence, Alzheimer's disease, and epilepsy

AU - Mizoguchi, Hiroyuki

AU - Yamada, Kiyofumi

AU - Nabeshima, Toshitaka

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) remodel the pericellular environment by regulating the cleavage of extracellular matrix proteins, cell surface components, neurotransmitter receptors, and growth factors that mediate cell adhesion, synaptogenesis, synaptic plasticity, and long-term potentiation. Interestingly, increased MMP activity and dysregulation of the balance between MMPs and TIMPs have also been implicated in various pathologic conditions. In this paper, we discuss various animal models that suggest that the activation of the gelatinases MMP-2 and MMP-9 is involved in pathogenesis of drug dependence, Alzheimer's disease, and epilepsy.

AB - Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) remodel the pericellular environment by regulating the cleavage of extracellular matrix proteins, cell surface components, neurotransmitter receptors, and growth factors that mediate cell adhesion, synaptogenesis, synaptic plasticity, and long-term potentiation. Interestingly, increased MMP activity and dysregulation of the balance between MMPs and TIMPs have also been implicated in various pathologic conditions. In this paper, we discuss various animal models that suggest that the activation of the gelatinases MMP-2 and MMP-9 is involved in pathogenesis of drug dependence, Alzheimer's disease, and epilepsy.

UR - http://www.scopus.com/inward/record.url?scp=84855599269&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855599269&partnerID=8YFLogxK

U2 - 10.1155/2011/681385

DO - 10.1155/2011/681385

M3 - Review article

JO - Biochemistry Research International

JF - Biochemistry Research International

SN - 2090-2247

M1 - 681385

ER -