Maturation of the QT Variability Index is Impaired in Preterm Infants

Arisa Kojima, Tadayoshi Hata, Tsuneaki Sadanaga, Yuri Mizutani, Hidetoshi Uchida, Yuri Kawai, Masahiko Manabe, Masayuki Fujino, Yoshihiko Eryu, Hiroko Boda, Masafumi Miyata, Tetsushi Yoshikawa

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Reduced heart rate (HR) variability in preterm infants compared with full-term infants suggests that autonomic cardiac control is developmentally delayed. However, the association between developmental changes in myocardial repolarization and gestational age remains unknown. This study investigated the association between the myocardial repolarization lability index, namely the QT variability index (QTVI) = log10 [(QTv/QTm2)/(HRv/HRm2)], and the perinatal profile of healthy 1-month-old infants. We included 209 infants (143 boys and 87 girls; mean gestational weeks at birth, 38.6 ± 1.7) who were born in university hospitals between 2014 and 2015 without apparent cardiac disease. We compared the ECG variability indices in 28 infants born before 37 gestational weeks (mean gestational weeks at birth, 35.6 ± 1.1 as preterm) and 181 infants born at the average number of gestational weeks (mean gestational weeks at birth, 38.8 ± 1.1 as controls). There was a negative correlation between the QTVI and gestational weeks (r = − 0.460, p = 0.035). QTVI values in preterm infants were larger than those in the controls (0.01 ± 0.50 vs. −0.26 ± 0.48, p = 0.023). In conclusion, the QTVI is negatively correlated with gestational age. The QTVI can serve as an index of the maturity of the cardiac autonomic nervous system and myocardial depolarization.

Original languageEnglish
Pages (from-to)902-905
Number of pages4
JournalPediatric Cardiology
Issue number5
Publication statusPublished - 01-06-2018

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine


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