Mechanical circulatory support combined with immunosuppression for the treatment of giant cell myocarditis ― a single-center experience in Japan ―

Seiko Nakajima-Doi, Hiroki Mochizuki, Keiichiro Iwasaki, Kensuke Kuroda, Takuya Watanabe, Naoki Tadokoro, Atsushi Okada, Yasuhide Asaumi, Hideaki Kanzaki, Satsuki Fukushima, Osamu Seguchi, Masanobu Yanase, Chisato Izumi, Tomoyuki Fujita, Junjiro Kobayashi, Norihide Fukushima

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: The therapeutic strategy for giant cell myocarditis (GCM) remains controversial, so we reviewed the clinical status of Japanese patients with GCM. Methods and Results: We retrospectively reviewed 6 consecutive patients with GCM requiring percutaneous mechanical circulatory support (p-MCS), with 3 further requiring ventricular assist devices. One patient died during p-MCS. Cardiac function improved in the other 5 with immunosuppressive therapy, but only 3 patients treated with dual immunosuppressants, including cyclosporine (CyA), achieved >1-year survival. Conclusions: The prognosis of patients with fulminant GCM is poor, but a treatment that combines MCS and early administration of CyA-based immunosuppressants will be useful.

Original languageEnglish
Pages (from-to)815-819
Number of pages5
JournalCirculation Journal
Volume84
Issue number5
DOIs
Publication statusPublished - 2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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