Mechanisms of inhibitions of DNA polymerase gamma by nucleotide analogues having anti-HIV activities.

S. Izuta, M. Saneyoshi, T. Sakurai, M. Suzuki, K. Kojima, S. Yoshida

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Inhibition mechanisms of 5'-triphosphates of 3'-azido-3'-deoxythymidine (AZT-TP) and 3'-deoxythymidine (ddTTP) on extensively purified DNA polymerase gamma from bovine testes were examined by analysis of the products synthesized on singly primed M13mp18 single-stranded DNA or synthetic oligonucleotide template-primer in the presence of analogues. The results indicate that AZT-TP inhibits DNA polymerase gamma in competition with dTTP but is not incorporated into DNA, whereas ddTTP is incorporated into DNA and causes chain termination.

Original languageEnglish
Pages (from-to)79-80
Number of pages2
JournalNucleic acids symposium series
Issue number25
Publication statusPublished - 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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