Memory impairment and morphological changes in rats after continuous infusion of active fragment of anti-nerve growth factor-antibody

T. Nabeshima, S. I. Ogawa, K. Yamada, H. Ishimaru, K. Fuji, T. Kameyama, T. Fukuta, R. Takeuchi, K. Hayashi

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

We report here that the specific Fab' fragment of anti-nerve growth factor (NGF)-antibody (anti-NGF, 12, 120 and 400 μg/4 weeks, i.c.v.) impairs learning and memory. The goal latency of the control rats in water maze task was rapidly shortened by training compared to those of the anti-NGF-treated rats. The degree of reduction in movement counts of the anti-NGF-treated rats in habituation task was significantly smaller than that of the control rats. However, the step-through latency of the anti-NGF-treated rats was not significantly shorter than that of the control rats. With regard to the choline acetyltransferase activity, no effects were observed in any of the brain regions. Anti-NGF treatment altered nuclear morphology in the hippocampus and parietal cortex. As a result, it seems that the anti-NGF- induced amnesia could be due to an impairment of nuclear morphology.

Original languageEnglish
Pages (from-to)141-152
Number of pages12
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume74
Issue number2
Publication statusPublished - 01-12-1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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