Abstract
We report here that the specific Fab' fragment of anti-nerve growth factor (NGF)-antibody (anti-NGF, 12, 120 and 400 μg/4 weeks, i.c.v.) impairs learning and memory. The goal latency of the control rats in water maze task was rapidly shortened by training compared to those of the anti-NGF-treated rats. The degree of reduction in movement counts of the anti-NGF-treated rats in habituation task was significantly smaller than that of the control rats. However, the step-through latency of the anti-NGF-treated rats was not significantly shorter than that of the control rats. With regard to the choline acetyltransferase activity, no effects were observed in any of the brain regions. Anti-NGF treatment altered nuclear morphology in the hippocampus and parietal cortex. As a result, it seems that the anti-NGF- induced amnesia could be due to an impairment of nuclear morphology.
| Original language | English |
|---|---|
| Pages (from-to) | 141-152 |
| Number of pages | 12 |
| Journal | Research Communications in Chemical Pathology and Pharmacology |
| Volume | 74 |
| Issue number | 2 |
| Publication status | Published - 01-12-1991 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
- Toxicology
- Pharmacology
- Pharmacology, Toxicology and Pharmaceutics(all)
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Memory impairment and morphological changes in rats after continuous infusion of active fragment of anti-nerve growth factor-antibody. / Nabeshima, Toshitaka; Ogawa, S. I.; Yamada, K.; Ishimaru, H.; Fuji, K.; Kameyama, T.; Fukuta, T.; Takeuchi, R.; Hayashi, K.
In: Research Communications in Chemical Pathology and Pharmacology, Vol. 74, No. 2, 01.12.1991, p. 141-152.Research output: Contribution to journal › Article
TY - JOUR
T1 - Memory impairment and morphological changes in rats after continuous infusion of active fragment of anti-nerve growth factor-antibody
AU - Nabeshima, Toshitaka
AU - Ogawa, S. I.
AU - Yamada, K.
AU - Ishimaru, H.
AU - Fuji, K.
AU - Kameyama, T.
AU - Fukuta, T.
AU - Takeuchi, R.
AU - Hayashi, K.
PY - 1991/12/1
Y1 - 1991/12/1
N2 - We report here that the specific Fab' fragment of anti-nerve growth factor (NGF)-antibody (anti-NGF, 12, 120 and 400 μg/4 weeks, i.c.v.) impairs learning and memory. The goal latency of the control rats in water maze task was rapidly shortened by training compared to those of the anti-NGF-treated rats. The degree of reduction in movement counts of the anti-NGF-treated rats in habituation task was significantly smaller than that of the control rats. However, the step-through latency of the anti-NGF-treated rats was not significantly shorter than that of the control rats. With regard to the choline acetyltransferase activity, no effects were observed in any of the brain regions. Anti-NGF treatment altered nuclear morphology in the hippocampus and parietal cortex. As a result, it seems that the anti-NGF- induced amnesia could be due to an impairment of nuclear morphology.
AB - We report here that the specific Fab' fragment of anti-nerve growth factor (NGF)-antibody (anti-NGF, 12, 120 and 400 μg/4 weeks, i.c.v.) impairs learning and memory. The goal latency of the control rats in water maze task was rapidly shortened by training compared to those of the anti-NGF-treated rats. The degree of reduction in movement counts of the anti-NGF-treated rats in habituation task was significantly smaller than that of the control rats. However, the step-through latency of the anti-NGF-treated rats was not significantly shorter than that of the control rats. With regard to the choline acetyltransferase activity, no effects were observed in any of the brain regions. Anti-NGF treatment altered nuclear morphology in the hippocampus and parietal cortex. As a result, it seems that the anti-NGF- induced amnesia could be due to an impairment of nuclear morphology.
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UR - http://www.scopus.com/inward/citedby.url?scp=0026344917&partnerID=8YFLogxK
M3 - Article
C2 - 1811278
AN - SCOPUS:0026344917
VL - 74
SP - 141
EP - 152
JO - Research Communications in Chemical Pathology and Pharmacology
JF - Research Communications in Chemical Pathology and Pharmacology
SN - 0034-5164
IS - 2
ER -