Memory impairment and morphological changes in rats after continuous infusion of active fragment of anti-nerve growth factor-antibody

T. Nabeshima; S. I. Ogawa; K. Yamada; H. Ishimaru; K. Fuji; T. Kameyama; T. Fukuta; R. Takeuchi; K. Hayashi

Memory impairment and morphological changes in rats after continuous infusion of active fragment of anti-nerve growth factor-antibody

T. Nabeshima, S. I. Ogawa, K. Yamada, H. Ishimaru, K. Fuji, T. Kameyama, T. Fukuta, R. Takeuchi, K. Hayashi

Research output: Contribution to journal › Article › peer-review

Abstract

We report here that the specific Fab' fragment of anti-nerve growth factor (NGF)-antibody (anti-NGF, 12, 120 and 400 μg/4 weeks, i.c.v.) impairs learning and memory. The goal latency of the control rats in water maze task was rapidly shortened by training compared to those of the anti-NGF-treated rats. The degree of reduction in movement counts of the anti-NGF-treated rats in habituation task was significantly smaller than that of the control rats. However, the step-through latency of the anti-NGF-treated rats was not significantly shorter than that of the control rats. With regard to the choline acetyltransferase activity, no effects were observed in any of the brain regions. Anti-NGF treatment altered nuclear morphology in the hippocampus and parietal cortex. As a result, it seems that the anti-NGF- induced amnesia could be due to an impairment of nuclear morphology.

Original language	English
Pages (from-to)	141-152
Number of pages	12
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	74
Issue number	2
Publication status	Published - 01-12-1991
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Toxicology
Pharmacology
Pharmacology, Toxicology and Pharmaceutics(all)

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title = "Memory impairment and morphological changes in rats after continuous infusion of active fragment of anti-nerve growth factor-antibody",

abstract = "We report here that the specific Fab' fragment of anti-nerve growth factor (NGF)-antibody (anti-NGF, 12, 120 and 400 μg/4 weeks, i.c.v.) impairs learning and memory. The goal latency of the control rats in water maze task was rapidly shortened by training compared to those of the anti-NGF-treated rats. The degree of reduction in movement counts of the anti-NGF-treated rats in habituation task was significantly smaller than that of the control rats. However, the step-through latency of the anti-NGF-treated rats was not significantly shorter than that of the control rats. With regard to the choline acetyltransferase activity, no effects were observed in any of the brain regions. Anti-NGF treatment altered nuclear morphology in the hippocampus and parietal cortex. As a result, it seems that the anti-NGF- induced amnesia could be due to an impairment of nuclear morphology.",

author = "T. Nabeshima and Ogawa, {S. I.} and K. Yamada and H. Ishimaru and K. Fuji and T. Kameyama and T. Fukuta and R. Takeuchi and K. Hayashi",

year = "1991",

month = dec,

day = "1",

language = "English",

volume = "74",

pages = "141--152",

journal = "Research Communications in Chemical Pathology and Pharmacology",

issn = "0034-5164",

publisher = "PJD Publications Ltd",

number = "2",

}

Memory impairment and morphological changes in rats after continuous infusion of active fragment of anti-nerve growth factor-antibody. / Nabeshima, T.; Ogawa, S. I.; Yamada, K.; Ishimaru, H.; Fuji, K.; Kameyama, T.; Fukuta, T.; Takeuchi, R.; Hayashi, K.

In: Research Communications in Chemical Pathology and Pharmacology, Vol. 74, No. 2, 01.12.1991, p. 141-152.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Memory impairment and morphological changes in rats after continuous infusion of active fragment of anti-nerve growth factor-antibody

AU - Nabeshima, T.

AU - Ogawa, S. I.

AU - Yamada, K.

AU - Ishimaru, H.

AU - Fuji, K.

AU - Kameyama, T.

AU - Fukuta, T.

AU - Takeuchi, R.

AU - Hayashi, K.

PY - 1991/12/1

Y1 - 1991/12/1

N2 - We report here that the specific Fab' fragment of anti-nerve growth factor (NGF)-antibody (anti-NGF, 12, 120 and 400 μg/4 weeks, i.c.v.) impairs learning and memory. The goal latency of the control rats in water maze task was rapidly shortened by training compared to those of the anti-NGF-treated rats. The degree of reduction in movement counts of the anti-NGF-treated rats in habituation task was significantly smaller than that of the control rats. However, the step-through latency of the anti-NGF-treated rats was not significantly shorter than that of the control rats. With regard to the choline acetyltransferase activity, no effects were observed in any of the brain regions. Anti-NGF treatment altered nuclear morphology in the hippocampus and parietal cortex. As a result, it seems that the anti-NGF- induced amnesia could be due to an impairment of nuclear morphology.

AB - We report here that the specific Fab' fragment of anti-nerve growth factor (NGF)-antibody (anti-NGF, 12, 120 and 400 μg/4 weeks, i.c.v.) impairs learning and memory. The goal latency of the control rats in water maze task was rapidly shortened by training compared to those of the anti-NGF-treated rats. The degree of reduction in movement counts of the anti-NGF-treated rats in habituation task was significantly smaller than that of the control rats. However, the step-through latency of the anti-NGF-treated rats was not significantly shorter than that of the control rats. With regard to the choline acetyltransferase activity, no effects were observed in any of the brain regions. Anti-NGF treatment altered nuclear morphology in the hippocampus and parietal cortex. As a result, it seems that the anti-NGF- induced amnesia could be due to an impairment of nuclear morphology.

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