Abstract
We report here that the specific Fab' fragment of anti-nerve growth factor (NGF)-antibody (anti-NGF, 12, 120 and 400 μg/4 weeks, i.c.v.) impairs learning and memory. The goal latency of the control rats in water maze task was rapidly shortened by training compared to those of the anti-NGF-treated rats. The degree of reduction in movement counts of the anti-NGF-treated rats in habituation task was significantly smaller than that of the control rats. However, the step-through latency of the anti-NGF-treated rats was not significantly shorter than that of the control rats. With regard to the choline acetyltransferase activity, no effects were observed in any of the brain regions. Anti-NGF treatment altered nuclear morphology in the hippocampus and parietal cortex. As a result, it seems that the anti-NGF- induced amnesia could be due to an impairment of nuclear morphology.
Original language | English |
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Pages (from-to) | 141-152 |
Number of pages | 12 |
Journal | Research Communications in Chemical Pathology and Pharmacology |
Volume | 74 |
Issue number | 2 |
Publication status | Published - 01-12-1991 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
- Toxicology
- Pharmacology
- Pharmacology, Toxicology and Pharmaceutics(all)