Memory impairment and morphological changes in rats after continuous infusion of active fragment of anti-nerve growth factor-antibody

Toshitaka Nabeshima, S. I. Ogawa, K. Yamada, H. Ishimaru, K. Fuji, T. Kameyama, T. Fukuta, R. Takeuchi, K. Hayashi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We report here that the specific Fab' fragment of anti-nerve growth factor (NGF)-antibody (anti-NGF, 12, 120 and 400 μg/4 weeks, i.c.v.) impairs learning and memory. The goal latency of the control rats in water maze task was rapidly shortened by training compared to those of the anti-NGF-treated rats. The degree of reduction in movement counts of the anti-NGF-treated rats in habituation task was significantly smaller than that of the control rats. However, the step-through latency of the anti-NGF-treated rats was not significantly shorter than that of the control rats. With regard to the choline acetyltransferase activity, no effects were observed in any of the brain regions. Anti-NGF treatment altered nuclear morphology in the hippocampus and parietal cortex. As a result, it seems that the anti-NGF- induced amnesia could be due to an impairment of nuclear morphology.

Original languageEnglish
Pages (from-to)141-152
Number of pages12
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume74
Issue number2
Publication statusPublished - 01-12-1991
Externally publishedYes

Fingerprint

Nerve Growth Factor
Rats
Data storage equipment
Rat control
Antibodies
Parietal Lobe
Immunoglobulin Fab Fragments
Choline O-Acetyltransferase
Amnesia
Anti-Idiotypic Antibodies
Hippocampus
Brain
Learning
Water

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Nabeshima, Toshitaka ; Ogawa, S. I. ; Yamada, K. ; Ishimaru, H. ; Fuji, K. ; Kameyama, T. ; Fukuta, T. ; Takeuchi, R. ; Hayashi, K. / Memory impairment and morphological changes in rats after continuous infusion of active fragment of anti-nerve growth factor-antibody. In: Research Communications in Chemical Pathology and Pharmacology. 1991 ; Vol. 74, No. 2. pp. 141-152.
@article{1d1acf454ea641fd9d8e827bd68e3f7a,
title = "Memory impairment and morphological changes in rats after continuous infusion of active fragment of anti-nerve growth factor-antibody",
abstract = "We report here that the specific Fab' fragment of anti-nerve growth factor (NGF)-antibody (anti-NGF, 12, 120 and 400 μg/4 weeks, i.c.v.) impairs learning and memory. The goal latency of the control rats in water maze task was rapidly shortened by training compared to those of the anti-NGF-treated rats. The degree of reduction in movement counts of the anti-NGF-treated rats in habituation task was significantly smaller than that of the control rats. However, the step-through latency of the anti-NGF-treated rats was not significantly shorter than that of the control rats. With regard to the choline acetyltransferase activity, no effects were observed in any of the brain regions. Anti-NGF treatment altered nuclear morphology in the hippocampus and parietal cortex. As a result, it seems that the anti-NGF- induced amnesia could be due to an impairment of nuclear morphology.",
author = "Toshitaka Nabeshima and Ogawa, {S. I.} and K. Yamada and H. Ishimaru and K. Fuji and T. Kameyama and T. Fukuta and R. Takeuchi and K. Hayashi",
year = "1991",
month = "12",
day = "1",
language = "English",
volume = "74",
pages = "141--152",
journal = "Research Communications in Chemical Pathology and Pharmacology",
issn = "0034-5164",
publisher = "PJD Publications Ltd",
number = "2",

}

Memory impairment and morphological changes in rats after continuous infusion of active fragment of anti-nerve growth factor-antibody. / Nabeshima, Toshitaka; Ogawa, S. I.; Yamada, K.; Ishimaru, H.; Fuji, K.; Kameyama, T.; Fukuta, T.; Takeuchi, R.; Hayashi, K.

In: Research Communications in Chemical Pathology and Pharmacology, Vol. 74, No. 2, 01.12.1991, p. 141-152.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Memory impairment and morphological changes in rats after continuous infusion of active fragment of anti-nerve growth factor-antibody

AU - Nabeshima, Toshitaka

AU - Ogawa, S. I.

AU - Yamada, K.

AU - Ishimaru, H.

AU - Fuji, K.

AU - Kameyama, T.

AU - Fukuta, T.

AU - Takeuchi, R.

AU - Hayashi, K.

PY - 1991/12/1

Y1 - 1991/12/1

N2 - We report here that the specific Fab' fragment of anti-nerve growth factor (NGF)-antibody (anti-NGF, 12, 120 and 400 μg/4 weeks, i.c.v.) impairs learning and memory. The goal latency of the control rats in water maze task was rapidly shortened by training compared to those of the anti-NGF-treated rats. The degree of reduction in movement counts of the anti-NGF-treated rats in habituation task was significantly smaller than that of the control rats. However, the step-through latency of the anti-NGF-treated rats was not significantly shorter than that of the control rats. With regard to the choline acetyltransferase activity, no effects were observed in any of the brain regions. Anti-NGF treatment altered nuclear morphology in the hippocampus and parietal cortex. As a result, it seems that the anti-NGF- induced amnesia could be due to an impairment of nuclear morphology.

AB - We report here that the specific Fab' fragment of anti-nerve growth factor (NGF)-antibody (anti-NGF, 12, 120 and 400 μg/4 weeks, i.c.v.) impairs learning and memory. The goal latency of the control rats in water maze task was rapidly shortened by training compared to those of the anti-NGF-treated rats. The degree of reduction in movement counts of the anti-NGF-treated rats in habituation task was significantly smaller than that of the control rats. However, the step-through latency of the anti-NGF-treated rats was not significantly shorter than that of the control rats. With regard to the choline acetyltransferase activity, no effects were observed in any of the brain regions. Anti-NGF treatment altered nuclear morphology in the hippocampus and parietal cortex. As a result, it seems that the anti-NGF- induced amnesia could be due to an impairment of nuclear morphology.

UR - http://www.scopus.com/inward/record.url?scp=0026344917&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026344917&partnerID=8YFLogxK

M3 - Article

C2 - 1811278

AN - SCOPUS:0026344917

VL - 74

SP - 141

EP - 152

JO - Research Communications in Chemical Pathology and Pharmacology

JF - Research Communications in Chemical Pathology and Pharmacology

SN - 0034-5164

IS - 2

ER -