Memory impairment and morphological changes in rats induced by active fragment of anti-nerve growth factor-antibody

Toshitaka Nabeshima, Shin ichi Ogawa, Hirohisa Ishimaru, Tsutomu Kameyama, Taneo Fukuta, Rie Takeuchi, Kyozo Hayashi

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Abstract

Treatment of rats with a specific Fab' fragment of anti-nerve growth factor (NGF)-antibody (anti-NGF, 12, 120 and 400 μg/4 weeks, i.c.v.) impaired their learning ability. The distance of swimming of anti-NGF treated rats in a water maze was shortened more slowly by training than that of control rats. Anti-NGF treatment altered the staining of nuclei of cells in the hippocampus, parietal cortex and dentate gyrus with hematoxylin. It is suggested that the anti-NGF-induced amnesia could be due to change in nuclear morphology.

Original languageEnglish
Pages (from-to)215-219
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume175
Issue number1
DOIs
Publication statusPublished - 28-02-1991

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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