TY - JOUR
T1 - Memory impairment and morphological changes in rats induced by active fragment of anti-nerve growth factor-antibody
AU - Nabeshima, Toshitaka
AU - Ogawa, Shin ichi
AU - Ishimaru, Hirohisa
AU - Kameyama, Tsutomu
AU - Fukuta, Taneo
AU - Takeuchi, Rie
AU - Hayashi, Kyozo
PY - 1991/2/28
Y1 - 1991/2/28
N2 - Treatment of rats with a specific Fab' fragment of anti-nerve growth factor (NGF)-antibody (anti-NGF, 12, 120 and 400 μg/4 weeks, i.c.v.) impaired their learning ability. The distance of swimming of anti-NGF treated rats in a water maze was shortened more slowly by training than that of control rats. Anti-NGF treatment altered the staining of nuclei of cells in the hippocampus, parietal cortex and dentate gyrus with hematoxylin. It is suggested that the anti-NGF-induced amnesia could be due to change in nuclear morphology.
AB - Treatment of rats with a specific Fab' fragment of anti-nerve growth factor (NGF)-antibody (anti-NGF, 12, 120 and 400 μg/4 weeks, i.c.v.) impaired their learning ability. The distance of swimming of anti-NGF treated rats in a water maze was shortened more slowly by training than that of control rats. Anti-NGF treatment altered the staining of nuclei of cells in the hippocampus, parietal cortex and dentate gyrus with hematoxylin. It is suggested that the anti-NGF-induced amnesia could be due to change in nuclear morphology.
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U2 - 10.1016/S0006-291X(05)81222-7
DO - 10.1016/S0006-291X(05)81222-7
M3 - Article
C2 - 1998505
AN - SCOPUS:0025978268
SN - 0006-291X
VL - 175
SP - 215
EP - 219
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -