Memory impairment and morphological changes in rats induced by active fragment of anti-nerve growth factor-antibody

Toshitaka Nabeshima; Shin ichi Ogawa; Hirohisa Ishimaru; Tsutomu Kameyama; Taneo Fukuta; Rie Takeuchi; Kyozo Hayashi

doi:10.1016/S0006-291X(05)81222-7

Memory impairment and morphological changes in rats induced by active fragment of anti-nerve growth factor-antibody

Toshitaka Nabeshima
, Shin ichi Ogawa
, Hirohisa Ishimaru
, Tsutomu Kameyama
, Taneo Fukuta
, Rie Takeuchi
, Kyozo Hayashi

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Treatment of rats with a specific Fab' fragment of anti-nerve growth factor (NGF)-antibody (anti-NGF, 12, 120 and 400 μg/4 weeks, i.c.v.) impaired their learning ability. The distance of swimming of anti-NGF treated rats in a water maze was shortened more slowly by training than that of control rats. Anti-NGF treatment altered the staining of nuclei of cells in the hippocampus, parietal cortex and dentate gyrus with hematoxylin. It is suggested that the anti-NGF-induced amnesia could be due to change in nuclear morphology.

Original language	English
Pages (from-to)	215-219
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	175
Issue number	1
DOIs	https://doi.org/10.1016/S0006-291X(05)81222-7
Publication status	Published - 28-02-1991
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/S0006-291X(05)81222-7

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abstract = "Treatment of rats with a specific Fab' fragment of anti-nerve growth factor (NGF)-antibody (anti-NGF, 12, 120 and 400 μg/4 weeks, i.c.v.) impaired their learning ability. The distance of swimming of anti-NGF treated rats in a water maze was shortened more slowly by training than that of control rats. Anti-NGF treatment altered the staining of nuclei of cells in the hippocampus, parietal cortex and dentate gyrus with hematoxylin. It is suggested that the anti-NGF-induced amnesia could be due to change in nuclear morphology.",

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AU - Nabeshima, Toshitaka

AU - Ogawa, Shin ichi

AU - Ishimaru, Hirohisa

AU - Kameyama, Tsutomu

AU - Fukuta, Taneo

AU - Takeuchi, Rie

AU - Hayashi, Kyozo

PY - 1991/2/28

Y1 - 1991/2/28

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AB - Treatment of rats with a specific Fab' fragment of anti-nerve growth factor (NGF)-antibody (anti-NGF, 12, 120 and 400 μg/4 weeks, i.c.v.) impaired their learning ability. The distance of swimming of anti-NGF treated rats in a water maze was shortened more slowly by training than that of control rats. Anti-NGF treatment altered the staining of nuclei of cells in the hippocampus, parietal cortex and dentate gyrus with hematoxylin. It is suggested that the anti-NGF-induced amnesia could be due to change in nuclear morphology.

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Memory impairment and morphological changes in rats induced by active fragment of anti-nerve growth factor-antibody

Abstract

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