Abstract
Nabeshima, T. and Nitta, A. Memory Impairment and Neuronal Dysfunction Induced by β-Amyloid Protein in Rats. Tohoku J. Exp. Med., 1994, 174 (3), 241-249 Alzheimer's disease (AD) is characterized by the presence of senile plaques. The core of the plaque consists of β-amyloid protein. In AD patients, learning and memory are impaired with a concomitant loss of the cholinergic marker enzyme, choline acetyltransferase (ChAT). However, direct evidence that βamyloid protein is related to the impairment of learning and memory has not been demonstrated. In this study, we investigated whether memory impairment and neuronal dysfunction were produced after 2 weeks continuous infusion of β-amyloid protein (3, 30 and 300 pmol/day) into the cerebral ventricles in adult rats. To investigate the ability of learning and memory in β-amyloid protein-treated rats, water maze and passive avoidance tasks were carried out. The performance of both tasks in β-amyloid protein-treated rats was impaired. ChAT activity in the frontal cortex (3 and 30 pmol/day) and hippocampus (300 pmol/day) significantly decreased. These results suggest that β-amyloid protein is related to the impairment of learning and memory, and neurodegeneration, and that β-amyloid protein-treated rats could be used as an animal model for AD. β-amyloid protein; Alzheimer's disease; memory; choline acetyltransferase; rats.
| Original language | English |
|---|---|
| Pages (from-to) | 241-249 |
| Number of pages | 9 |
| Journal | Tohoku Journal of Experimental Medicine |
| Volume | 174 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 01-01-1994 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
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Memory Impairment and Neuronal Dysfunction Induced by β-Amyloid Protein in Rats. / Nabeshima, Toshitaka; Nitta, Atsumi.
In: Tohoku Journal of Experimental Medicine, Vol. 174, No. 3, 01.01.1994, p. 241-249.Research output: Contribution to journal › Article
TY - JOUR
T1 - Memory Impairment and Neuronal Dysfunction Induced by β-Amyloid Protein in Rats
AU - Nabeshima, Toshitaka
AU - Nitta, Atsumi
PY - 1994/1/1
Y1 - 1994/1/1
N2 - Nabeshima, T. and Nitta, A. Memory Impairment and Neuronal Dysfunction Induced by β-Amyloid Protein in Rats. Tohoku J. Exp. Med., 1994, 174 (3), 241-249 Alzheimer's disease (AD) is characterized by the presence of senile plaques. The core of the plaque consists of β-amyloid protein. In AD patients, learning and memory are impaired with a concomitant loss of the cholinergic marker enzyme, choline acetyltransferase (ChAT). However, direct evidence that βamyloid protein is related to the impairment of learning and memory has not been demonstrated. In this study, we investigated whether memory impairment and neuronal dysfunction were produced after 2 weeks continuous infusion of β-amyloid protein (3, 30 and 300 pmol/day) into the cerebral ventricles in adult rats. To investigate the ability of learning and memory in β-amyloid protein-treated rats, water maze and passive avoidance tasks were carried out. The performance of both tasks in β-amyloid protein-treated rats was impaired. ChAT activity in the frontal cortex (3 and 30 pmol/day) and hippocampus (300 pmol/day) significantly decreased. These results suggest that β-amyloid protein is related to the impairment of learning and memory, and neurodegeneration, and that β-amyloid protein-treated rats could be used as an animal model for AD. β-amyloid protein; Alzheimer's disease; memory; choline acetyltransferase; rats.
AB - Nabeshima, T. and Nitta, A. Memory Impairment and Neuronal Dysfunction Induced by β-Amyloid Protein in Rats. Tohoku J. Exp. Med., 1994, 174 (3), 241-249 Alzheimer's disease (AD) is characterized by the presence of senile plaques. The core of the plaque consists of β-amyloid protein. In AD patients, learning and memory are impaired with a concomitant loss of the cholinergic marker enzyme, choline acetyltransferase (ChAT). However, direct evidence that βamyloid protein is related to the impairment of learning and memory has not been demonstrated. In this study, we investigated whether memory impairment and neuronal dysfunction were produced after 2 weeks continuous infusion of β-amyloid protein (3, 30 and 300 pmol/day) into the cerebral ventricles in adult rats. To investigate the ability of learning and memory in β-amyloid protein-treated rats, water maze and passive avoidance tasks were carried out. The performance of both tasks in β-amyloid protein-treated rats was impaired. ChAT activity in the frontal cortex (3 and 30 pmol/day) and hippocampus (300 pmol/day) significantly decreased. These results suggest that β-amyloid protein is related to the impairment of learning and memory, and neurodegeneration, and that β-amyloid protein-treated rats could be used as an animal model for AD. β-amyloid protein; Alzheimer's disease; memory; choline acetyltransferase; rats.
UR - http://www.scopus.com/inward/record.url?scp=0028544333&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028544333&partnerID=8YFLogxK
U2 - 10.1620/tjem.174.241
DO - 10.1620/tjem.174.241
M3 - Article
C2 - 7761989
AN - SCOPUS:0028544333
VL - 174
SP - 241
EP - 249
JO - Tohoku Journal of Experimental Medicine
JF - Tohoku Journal of Experimental Medicine
SN - 0040-8727
IS - 3
ER -