Menstrual and reproductive factors and the mortality risk of gastric cancer in Japanese menopausal females

Satoshi Kaneko, Akiko Tamakoshi, Yoshiyuki Ohno, Tetsuya Mizoue, Takesumi Yoshimura, Hideaki Toyoshima, Mitsuru Mori, Yutaka Motohashi, Shigeru Hisamichi, Yosikazu Nakamura, Takashi Shimamoto, Haruo Mikami, Shuji Hashimoto, Yutaka Inaba, Heizo Tanaka, Yoshiharu Hoshiyama, Hiroshi Suzuki, Hiroyuki Shimizu, Shinkan Tokudome, Yoshinori ItoAkio Koizumi, Takashi Kawamura, Yoshiyuki Watanabe, Masahiro Nakao, Takaichiro Suzuki, Tsutomu Hashimoto, Takayuki Nose, Norihiko Hayakawa, Katsuhiro Fukuda, Tomoyuki Kitagawa, Toshio Kuroki, Naoyuki Okamoto, Teruo Ishibashi, Hideo Shio, Kazuo Tajima

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Objective: The relationship between gastric cancer and menstrual and reproductive history was investigated for 40,535 postmenopausal females from a large-scale prospective cohort in Japan (JACC: Japan Collaborative Cohort Study for Evaluation of Cancer Risk, sponsored by Monbusho). Methods: A Cox proportional hazard model was used to estimate risk with respect to menstrual and reproductive factors for gastric cancer mortality. The effects on risk of potential confounders such as lifestyle, dietary habits, and socioeconomic status were controlled for using a stepwise procedure. Results: During the study period (mean 8.2 years), 156 deaths due to gastric cancer were identified. Longer fertility tended to be inversely associated with risk of gastric cancer mortality, although the association was not significant. Late menopause had no obvious effect on gastric cancer risk. The risk ratio of delivery experience compared to no delivery was 0.62 (95% confidence interval 0.27-1.41), and this effect was consistent regardless of the number of deliveries. Early menarche was not associated with the risk of gastric cancer. The potential confounders were not seen to have distinct effects on the associations. Conclusions: Multiparity appears to confer a protective tendency on gastric cancer mortality; however, this result is inconsistent with previous reports. Further information needs to be accumulated from epidemiological studies in order to clarify the role of reproductive factors in gastric cancer.

Original languageEnglish
Pages (from-to)53-59
Number of pages7
JournalCancer Causes and Control
Volume14
Issue number1
DOIs
Publication statusPublished - 01-02-2003
Externally publishedYes

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Stomach Neoplasms
Mortality
Japan
Reproductive History
Menarche
Feeding Behavior
Menopause
Parity
Proportional Hazards Models
Social Class
Fertility
Life Style
Epidemiologic Studies
Cohort Studies
Odds Ratio
Confidence Intervals
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kaneko, S., Tamakoshi, A., Ohno, Y., Mizoue, T., Yoshimura, T., Toyoshima, H., ... Tajima, K. (2003). Menstrual and reproductive factors and the mortality risk of gastric cancer in Japanese menopausal females. Cancer Causes and Control, 14(1), 53-59. https://doi.org/10.1023/A:1022596104796
Kaneko, Satoshi ; Tamakoshi, Akiko ; Ohno, Yoshiyuki ; Mizoue, Tetsuya ; Yoshimura, Takesumi ; Toyoshima, Hideaki ; Mori, Mitsuru ; Motohashi, Yutaka ; Hisamichi, Shigeru ; Nakamura, Yosikazu ; Shimamoto, Takashi ; Mikami, Haruo ; Hashimoto, Shuji ; Inaba, Yutaka ; Tanaka, Heizo ; Hoshiyama, Yoshiharu ; Suzuki, Hiroshi ; Shimizu, Hiroyuki ; Tokudome, Shinkan ; Ito, Yoshinori ; Koizumi, Akio ; Kawamura, Takashi ; Watanabe, Yoshiyuki ; Nakao, Masahiro ; Suzuki, Takaichiro ; Hashimoto, Tsutomu ; Nose, Takayuki ; Hayakawa, Norihiko ; Fukuda, Katsuhiro ; Kitagawa, Tomoyuki ; Kuroki, Toshio ; Okamoto, Naoyuki ; Ishibashi, Teruo ; Shio, Hideo ; Tajima, Kazuo. / Menstrual and reproductive factors and the mortality risk of gastric cancer in Japanese menopausal females. In: Cancer Causes and Control. 2003 ; Vol. 14, No. 1. pp. 53-59.
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abstract = "Objective: The relationship between gastric cancer and menstrual and reproductive history was investigated for 40,535 postmenopausal females from a large-scale prospective cohort in Japan (JACC: Japan Collaborative Cohort Study for Evaluation of Cancer Risk, sponsored by Monbusho). Methods: A Cox proportional hazard model was used to estimate risk with respect to menstrual and reproductive factors for gastric cancer mortality. The effects on risk of potential confounders such as lifestyle, dietary habits, and socioeconomic status were controlled for using a stepwise procedure. Results: During the study period (mean 8.2 years), 156 deaths due to gastric cancer were identified. Longer fertility tended to be inversely associated with risk of gastric cancer mortality, although the association was not significant. Late menopause had no obvious effect on gastric cancer risk. The risk ratio of delivery experience compared to no delivery was 0.62 (95{\%} confidence interval 0.27-1.41), and this effect was consistent regardless of the number of deliveries. Early menarche was not associated with the risk of gastric cancer. The potential confounders were not seen to have distinct effects on the associations. Conclusions: Multiparity appears to confer a protective tendency on gastric cancer mortality; however, this result is inconsistent with previous reports. Further information needs to be accumulated from epidemiological studies in order to clarify the role of reproductive factors in gastric cancer.",
author = "Satoshi Kaneko and Akiko Tamakoshi and Yoshiyuki Ohno and Tetsuya Mizoue and Takesumi Yoshimura and Hideaki Toyoshima and Mitsuru Mori and Yutaka Motohashi and Shigeru Hisamichi and Yosikazu Nakamura and Takashi Shimamoto and Haruo Mikami and Shuji Hashimoto and Yutaka Inaba and Heizo Tanaka and Yoshiharu Hoshiyama and Hiroshi Suzuki and Hiroyuki Shimizu and Shinkan Tokudome and Yoshinori Ito and Akio Koizumi and Takashi Kawamura and Yoshiyuki Watanabe and Masahiro Nakao and Takaichiro Suzuki and Tsutomu Hashimoto and Takayuki Nose and Norihiko Hayakawa and Katsuhiro Fukuda and Tomoyuki Kitagawa and Toshio Kuroki and Naoyuki Okamoto and Teruo Ishibashi and Hideo Shio and Kazuo Tajima",
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Kaneko, S, Tamakoshi, A, Ohno, Y, Mizoue, T, Yoshimura, T, Toyoshima, H, Mori, M, Motohashi, Y, Hisamichi, S, Nakamura, Y, Shimamoto, T, Mikami, H, Hashimoto, S, Inaba, Y, Tanaka, H, Hoshiyama, Y, Suzuki, H, Shimizu, H, Tokudome, S, Ito, Y, Koizumi, A, Kawamura, T, Watanabe, Y, Nakao, M, Suzuki, T, Hashimoto, T, Nose, T, Hayakawa, N, Fukuda, K, Kitagawa, T, Kuroki, T, Okamoto, N, Ishibashi, T, Shio, H & Tajima, K 2003, 'Menstrual and reproductive factors and the mortality risk of gastric cancer in Japanese menopausal females', Cancer Causes and Control, vol. 14, no. 1, pp. 53-59. https://doi.org/10.1023/A:1022596104796

Menstrual and reproductive factors and the mortality risk of gastric cancer in Japanese menopausal females. / Kaneko, Satoshi; Tamakoshi, Akiko; Ohno, Yoshiyuki; Mizoue, Tetsuya; Yoshimura, Takesumi; Toyoshima, Hideaki; Mori, Mitsuru; Motohashi, Yutaka; Hisamichi, Shigeru; Nakamura, Yosikazu; Shimamoto, Takashi; Mikami, Haruo; Hashimoto, Shuji; Inaba, Yutaka; Tanaka, Heizo; Hoshiyama, Yoshiharu; Suzuki, Hiroshi; Shimizu, Hiroyuki; Tokudome, Shinkan; Ito, Yoshinori; Koizumi, Akio; Kawamura, Takashi; Watanabe, Yoshiyuki; Nakao, Masahiro; Suzuki, Takaichiro; Hashimoto, Tsutomu; Nose, Takayuki; Hayakawa, Norihiko; Fukuda, Katsuhiro; Kitagawa, Tomoyuki; Kuroki, Toshio; Okamoto, Naoyuki; Ishibashi, Teruo; Shio, Hideo; Tajima, Kazuo.

In: Cancer Causes and Control, Vol. 14, No. 1, 01.02.2003, p. 53-59.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Menstrual and reproductive factors and the mortality risk of gastric cancer in Japanese menopausal females

AU - Kaneko, Satoshi

AU - Tamakoshi, Akiko

AU - Ohno, Yoshiyuki

AU - Mizoue, Tetsuya

AU - Yoshimura, Takesumi

AU - Toyoshima, Hideaki

AU - Mori, Mitsuru

AU - Motohashi, Yutaka

AU - Hisamichi, Shigeru

AU - Nakamura, Yosikazu

AU - Shimamoto, Takashi

AU - Mikami, Haruo

AU - Hashimoto, Shuji

AU - Inaba, Yutaka

AU - Tanaka, Heizo

AU - Hoshiyama, Yoshiharu

AU - Suzuki, Hiroshi

AU - Shimizu, Hiroyuki

AU - Tokudome, Shinkan

AU - Ito, Yoshinori

AU - Koizumi, Akio

AU - Kawamura, Takashi

AU - Watanabe, Yoshiyuki

AU - Nakao, Masahiro

AU - Suzuki, Takaichiro

AU - Hashimoto, Tsutomu

AU - Nose, Takayuki

AU - Hayakawa, Norihiko

AU - Fukuda, Katsuhiro

AU - Kitagawa, Tomoyuki

AU - Kuroki, Toshio

AU - Okamoto, Naoyuki

AU - Ishibashi, Teruo

AU - Shio, Hideo

AU - Tajima, Kazuo

PY - 2003/2/1

Y1 - 2003/2/1

N2 - Objective: The relationship between gastric cancer and menstrual and reproductive history was investigated for 40,535 postmenopausal females from a large-scale prospective cohort in Japan (JACC: Japan Collaborative Cohort Study for Evaluation of Cancer Risk, sponsored by Monbusho). Methods: A Cox proportional hazard model was used to estimate risk with respect to menstrual and reproductive factors for gastric cancer mortality. The effects on risk of potential confounders such as lifestyle, dietary habits, and socioeconomic status were controlled for using a stepwise procedure. Results: During the study period (mean 8.2 years), 156 deaths due to gastric cancer were identified. Longer fertility tended to be inversely associated with risk of gastric cancer mortality, although the association was not significant. Late menopause had no obvious effect on gastric cancer risk. The risk ratio of delivery experience compared to no delivery was 0.62 (95% confidence interval 0.27-1.41), and this effect was consistent regardless of the number of deliveries. Early menarche was not associated with the risk of gastric cancer. The potential confounders were not seen to have distinct effects on the associations. Conclusions: Multiparity appears to confer a protective tendency on gastric cancer mortality; however, this result is inconsistent with previous reports. Further information needs to be accumulated from epidemiological studies in order to clarify the role of reproductive factors in gastric cancer.

AB - Objective: The relationship between gastric cancer and menstrual and reproductive history was investigated for 40,535 postmenopausal females from a large-scale prospective cohort in Japan (JACC: Japan Collaborative Cohort Study for Evaluation of Cancer Risk, sponsored by Monbusho). Methods: A Cox proportional hazard model was used to estimate risk with respect to menstrual and reproductive factors for gastric cancer mortality. The effects on risk of potential confounders such as lifestyle, dietary habits, and socioeconomic status were controlled for using a stepwise procedure. Results: During the study period (mean 8.2 years), 156 deaths due to gastric cancer were identified. Longer fertility tended to be inversely associated with risk of gastric cancer mortality, although the association was not significant. Late menopause had no obvious effect on gastric cancer risk. The risk ratio of delivery experience compared to no delivery was 0.62 (95% confidence interval 0.27-1.41), and this effect was consistent regardless of the number of deliveries. Early menarche was not associated with the risk of gastric cancer. The potential confounders were not seen to have distinct effects on the associations. Conclusions: Multiparity appears to confer a protective tendency on gastric cancer mortality; however, this result is inconsistent with previous reports. Further information needs to be accumulated from epidemiological studies in order to clarify the role of reproductive factors in gastric cancer.

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