Mental stress-induced changes in plasma serotonin, tryptophan, kynurenine concentrations in healthy participants

R. Teradaira, Y. Itoh, K. Kawai, Hiroaki Ishikawa, Koji Ohashi, Y. Nagamura

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In order to investigate the effect of mental stress on the tryptophan metabolism, a stress model of visual display terminals work was loaded on healthy students. Before and just after stress, plasma samples were collected and serotonin, tryptophan and kynurenine were assayed. The plasma concentration of serotonin was increased by visual display terminals work. Both Trp and Kyn concentrations were decreased after stress load. These results suggest that serotonin formation from tryptophan may be accelerated, resulting in the suppressing of kynurenine metabolism from tryptophan. Furthermore, when these subjects were divided into two groups, one group of those accustomed to the personal computer and another group of those not accustomed, the changes of above amines and scores of Profile of Mood States in the latter group were larger than that in the former group. These results also suggest that the activation of the person with a strong psychological load is larger than that of a weak person.

Original languageEnglish
Pages (from-to)175-179
Number of pages5
JournalInternational Congress Series
Volume1304
DOIs
Publication statusPublished - 01-11-2007

Fingerprint

Kynurenine
Tryptophan
Serotonin
Healthy Volunteers
Microcomputers
Amines
Students
Psychology

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{d28fd9d7e3de4a4083ab55997afceccf,
title = "Mental stress-induced changes in plasma serotonin, tryptophan, kynurenine concentrations in healthy participants",
abstract = "In order to investigate the effect of mental stress on the tryptophan metabolism, a stress model of visual display terminals work was loaded on healthy students. Before and just after stress, plasma samples were collected and serotonin, tryptophan and kynurenine were assayed. The plasma concentration of serotonin was increased by visual display terminals work. Both Trp and Kyn concentrations were decreased after stress load. These results suggest that serotonin formation from tryptophan may be accelerated, resulting in the suppressing of kynurenine metabolism from tryptophan. Furthermore, when these subjects were divided into two groups, one group of those accustomed to the personal computer and another group of those not accustomed, the changes of above amines and scores of Profile of Mood States in the latter group were larger than that in the former group. These results also suggest that the activation of the person with a strong psychological load is larger than that of a weak person.",
author = "R. Teradaira and Y. Itoh and K. Kawai and Hiroaki Ishikawa and Koji Ohashi and Y. Nagamura",
year = "2007",
month = "11",
day = "1",
doi = "10.1016/j.ics.2007.07.006",
language = "English",
volume = "1304",
pages = "175--179",
journal = "International Congress Series",
issn = "0531-5131",
publisher = "Elsevier BV",

}

Mental stress-induced changes in plasma serotonin, tryptophan, kynurenine concentrations in healthy participants. / Teradaira, R.; Itoh, Y.; Kawai, K.; Ishikawa, Hiroaki; Ohashi, Koji; Nagamura, Y.

In: International Congress Series, Vol. 1304, 01.11.2007, p. 175-179.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Mental stress-induced changes in plasma serotonin, tryptophan, kynurenine concentrations in healthy participants

AU - Teradaira, R.

AU - Itoh, Y.

AU - Kawai, K.

AU - Ishikawa, Hiroaki

AU - Ohashi, Koji

AU - Nagamura, Y.

PY - 2007/11/1

Y1 - 2007/11/1

N2 - In order to investigate the effect of mental stress on the tryptophan metabolism, a stress model of visual display terminals work was loaded on healthy students. Before and just after stress, plasma samples were collected and serotonin, tryptophan and kynurenine were assayed. The plasma concentration of serotonin was increased by visual display terminals work. Both Trp and Kyn concentrations were decreased after stress load. These results suggest that serotonin formation from tryptophan may be accelerated, resulting in the suppressing of kynurenine metabolism from tryptophan. Furthermore, when these subjects were divided into two groups, one group of those accustomed to the personal computer and another group of those not accustomed, the changes of above amines and scores of Profile of Mood States in the latter group were larger than that in the former group. These results also suggest that the activation of the person with a strong psychological load is larger than that of a weak person.

AB - In order to investigate the effect of mental stress on the tryptophan metabolism, a stress model of visual display terminals work was loaded on healthy students. Before and just after stress, plasma samples were collected and serotonin, tryptophan and kynurenine were assayed. The plasma concentration of serotonin was increased by visual display terminals work. Both Trp and Kyn concentrations were decreased after stress load. These results suggest that serotonin formation from tryptophan may be accelerated, resulting in the suppressing of kynurenine metabolism from tryptophan. Furthermore, when these subjects were divided into two groups, one group of those accustomed to the personal computer and another group of those not accustomed, the changes of above amines and scores of Profile of Mood States in the latter group were larger than that in the former group. These results also suggest that the activation of the person with a strong psychological load is larger than that of a weak person.

UR - http://www.scopus.com/inward/record.url?scp=35948938864&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35948938864&partnerID=8YFLogxK

U2 - 10.1016/j.ics.2007.07.006

DO - 10.1016/j.ics.2007.07.006

M3 - Article

VL - 1304

SP - 175

EP - 179

JO - International Congress Series

JF - International Congress Series

SN - 0531-5131

ER -