Mesenchymal stem cell-organized bone marrow elements: An alternative hematopoietic progenitor resource

Yasuo Miura, Zhigang Gao, Masako Miura, Byoung Moo Seo, Wataru Sonoyama, Wanjun Chen, Stan Gronthos, Li Zhang, Songtao Shi

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

Bone marrow-derived mesenchymal stem cells (BMMSCs) are multipotent postnatal stem cells that have been used for the treatment of bone defects and graft-versus-host diseases in clinics. In this study, we found that subcutaneously transplanted human BMMSCs are capable of organizing hematopoietic progenitors of recipient origin. These hematopoietic cells expressed multiple lineages of hematopoietic cell associated markers and were able to rescue lethally irradiated mice, with successful engraftment in the recipient, suggesting a potential bone marrow (BM) resource for stem cell therapies. Furthermore, we found that platelet-derived growth factor (PDGF) promotes the formation of BMMSC-generated BM niches through upregulation of β-catenin, implying that the PDGF pathway contributes to the formation of ectopic BM. These results indicate that the BMMSC-organized BM niche system represents a unique hematopoietic progenitor resource possessing potential clinical value.

Original languageEnglish
Pages (from-to)2428-2436
Number of pages9
JournalStem Cells
Volume24
Issue number11
DOIs
Publication statusPublished - 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology

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